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Human immunodeficiency virus (HIV) infection progresses to acquired immunodeficiency syndrome (AIDS). HIV targets and eliminates CD4 T cells, impairing immunity and leaving the body open to deadly infections and malignancies. When the immune system is seriously weakened, which frequently happens years after the initial HIV infection if treatment is not received, AIDS is diagnosed. Antiretroviral medication can manage the illness, but there is no cure. The acquired immunodeficiency syndrome pipeline analysis by Expert Market Research focuses on various treatment options for this disease. Increasing research, improved diagnostics, and innovative treatments are expected to fuel the growth of acquired immunodeficiency syndrome drug candidates in the coming years.
Major companies involved in the acquired immunodeficiency syndrome pipeline analysis include AbbVie, Merck Sharp & Dohme LLC and Gilead Sciences, among others.
Leading drugs currently in the pipeline include Budigalimab, Trimodulin, and others.
Advancements in novel therapies are driving pipeline growth. Increased investment in research and development, along with regulatory support, is accelerating clinical trials and new treatment approvals.
The Acquired Immunodeficiency Syndrome Pipeline Analysis Report by Expert Market Research gives comprehensive insights into acquired immunodeficiency syndrome therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for acquired immunodeficiency syndrome. The acquired immunodeficiency syndrome therapeutics report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The acquired immunodeficiency syndrome pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with acquired immunodeficiency syndrome treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to acquired immunodeficiency syndrome.

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Acquired immunodeficiency syndrome (AIDS) results when HIV gradually kills CD4+ T-helper cells (the main immune response coordinators). HIV infects these cells by attaching itself to CD4 and chemokine receptors, integrating its genome, and inducing cell death by apoptosis, immune-mediated destruction, and direct cytotoxic effects. Chronic immunological activation and the ensuing CD4+ T-cell depletion impair cell-mediated immunity, making people more vulnerable to malignancies and opportunistic infections.
Lifelong antiretroviral therapy (ART), which employs a mix of HIV medications to inhibit viral replication, is the treatment for acquired immunodeficiency syndrome (AIDS). ART minimizes the risk of transmission, maintains immune function, prevents opportunistic infections, and lowers the viral load to undetectable levels, but it cannot cure HIV. People with AIDS can live longer, healthier lives thanks to early and regular ART, which also turns HIV/AIDS into a chronic illness that can be managed.
In 2023, around 39.9 million people worldwide were predicted to be infected with HIV (the virus that causes AIDS). Globally, the median prevalence of HIV in persons aged 15–49 was 0.8%. Approximately 630,000 people died from AIDS-related causes in that year, which is a 69% drop from the high in 2004. The prevalence is higher among marginalized populations, including injecting drug users and men who have intercourse with other men.
This section of the report covers the analysis of acquired immunodeficiency syndrome drug candidates based on several segmentations, including:
By Phase
By Drug Class
By Route of Administration
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, in the acquired immunodeficiency syndrome pipeline, majority of the candidates are in Phase III with 38% of candidates followed by Phase II with 34% of candidates. The remaining 23% candidates are in Phase I and lastly 6% of candidates in Phase IV demonstrating a broad spectrum of development stages and progress toward potential treatments.
The drug molecule categories covered under the acquired immunodeficiency syndrome pipeline analysis include small molecules, RNA-based therapies, peptides, biologics, and gene editing therapies. The acquired immunodeficiency syndrome report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for acquired immunodeficiency syndrome.
Biologics are emerging as promising agents in the acquired immunodeficiency syndrome pipeline. For example, Budigalimab, a humanized IgG1 monoclonal antibody that targets PD-1 (Programmed cell death protein 1), an immune checkpoint receptor.
The EMR report for the acquired immunodeficiency syndrome pipeline analysis covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in acquired immunodeficiency syndrome clinical trials:
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for acquired immunodeficiency syndrome. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of acquired immunodeficiency syndrome drug candidates.
AbbVie developed the humanized IgG1 monoclonal antibody budigalimab (ABBV-181), which targets the PD-1 receptor, a crucial immunological checkpoint. It was first explored for cancer; however it is currently being studied for HIV in a Phase 2 clinical trial. Budigalimab alone or in combination with ABBV-382 is administered to patients on stable antiretroviral therapy during a monitored treatment interruption to improve HIV immunological control. Over roughly 112 weeks, the trial evaluates pharmacokinetics, safety, and efficacy.
Merck Sharp & Dohme LLC developed the experimental, once-daily, oral, two-drug regimen known as Doravirine/Islatravir (DOR/ISL) to treat HIV-1 infection. Islatravir is a nucleoside reverse transcriptase translocation inhibitor (NRTTI), while doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). In Phase 3 trials, DOR/ISL showed no treatment-emergent resistance and a similar safety profile to traditional antiretroviral treatments in terms of maintaining viral suppression at Week 48.
*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*
The Acquired Immunodeficiency Syndrome Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for acquired immunodeficiency syndrome. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into acquired immunodeficiency syndrome collaborations, regulatory environments, and potential growth opportunities.
Acquired Immunodeficiency Syndrome (AIDS) Epidemiology Forecast
Human Immunodeficiency Virus (HIV 1) Infection Pipeline Analysis Report
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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