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Hemorrhagic fever is a severe viral disease characterized by fever, bleeding, and multi-organ dysfunction. As per Sita Kumari Karanam, et al., 2025, 10%–40% of infected individuals may die during Crimean-Congo hemorrhagic fever (CCHFV) outbreaks, highlighting its high fatality rate. According to the hemorrhagic fever pipeline analysis by Expert Market Research, current therapies are mainly supportive, but the drug pipeline is increasingly focusing on antiviral agents, vaccines, and targeted therapeutics. The growing research on rapid diagnostics, outbreak management, and effective prophylactic measures is expected to drive significant pipeline expansion and improve patient outcomes in the coming years.
Major companies involved in the hemorrhagic fever pipeline analysis include Merck Sharp & Dohme LLC, Novartis Pharmaceuticals, and others.
Leading drugs currently in the pipeline include V181-005, EYU688, AVX70120, and others.
The pipeline is expected to expand through increased development of antiviral therapies, advancements in vaccine candidates, and the integration of monoclonal antibodies, addressing high unmet medical needs and emerging outbreak threats globally.
The Hemorrhagic Fever Pipeline Analysis Report by Expert Market Research gives comprehensive insights into hemorrhagic fever therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for hemorrhagic fever. The hemorrhagic fever report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The hemorrhagic fever pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with hemorrhagic fever treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to hemorrhagic fever.

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Hemorrhagic fever is a severe viral illness characterized by fever, bleeding, and organ dysfunction. It occurs when viruses, such as dengue, Ebola, or Lassa, enter the bloodstream, triggering widespread inflammation, capillary leakage, and impaired clotting, which can lead to shock or multi-organ failure. Transmission often involves mosquito bites, contact with infected bodily fluids, or contaminated surfaces.
Hemorrhagic fever treatments focus on supportive care, including fluid replacement, electrolyte management, and blood transfusions. Antiviral therapies, when available, target specific viruses to reduce viral load and improve patient outcomes, while vaccination prevents infection in high-risk populations. In December 2022, Takeda received approval for QDENGA® (Dengue Tetravalent Vaccine [Live, Attenuated]) represents a key advancement. It offers protection against all four dengue virus serotypes for individuals aged four years and older in the European Union, demonstrating robust efficacy and safety in more than 28,000 participants across 19 clinical trials.
The pipeline is gaining focus due to rising incidence and high mortality rates. According to Sita Kumari Karanam et al., 2025, Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes case fatality rates between 10% and 40%, spreading through tick bites or contact with infected animal blood or tissues. Epidemiology in India shows Gujarat as a hotspot, with sporadic cases reported since 2011, while Africa recorded 494 cases with 115 fatalities between 1956 and 2020. As per reports, virus segments encode glycoproteins, nucleocapsid, and RNA polymerase, serving as potential drug targets. Ongoing research focuses on developing effective therapeutics.
This section of the report covers the analysis of hemorrhagic fever drug candidates based on several segmentations, including:
By Phase
The pipeline assessment report covers 50+ drug analyses based on phase:
By Drug Class
The hemorrhagic fever pipeline analysis report covers 50+ drug analyses based on drug classes:
By Route of Administration
The pipeline assessment report covers 50+ drug analyses based on the route of administration:
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase II covers a major share of the total hemorrhagic fever clinical trials, with 48% share, reflecting strong clinical development activity. Phase III follows with 31%, indicating significant late-stage progress. Phase I contributes 13%, early phase I, while early phase I accounts for a smaller share of the pipeline. This balanced phase distribution supports robust innovation and market growth opportunities.
The drug molecule categories covered under the hemorrhagic fever pipeline analysis include small molecules, monoclonal antibodies, oligonucleotides, and vaccines. The hemorrhagic fever report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for hemorrhagic fever. Vaccine-based therapies are the primary focus due to the absence of approved antiviral treatments. For instance, the YFV-17D live-attenuated yellow fever vaccine shows a smooth and stable surface that enhances immune recognition. Research on structural differences with virulent strains is also underway to guide improved vaccine design and antiviral strategies against related flaviviruses.
The EMR report for the hemorrhagic fever pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed hemorrhagic fever therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in hemorrhagic fever clinical trials:
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for hemorrhagic fever. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of hemorrhagic fever drug candidates.
V181, developed by Merck, is a live attenuated quadrivalent dengue vaccine designed for single-dose administration to prevent dengue disease caused by all four dengue virus serotypes (DENV-1, DENV-2, DENV-3, DENV-4). The ongoing MOBILIZE-1 Phase 3 study is examining the safety, immunogenicity, and efficacy of V181 in approximately 12,000 healthy individuals aged 2–17 across dengue-endemic regions in the Asia-Pacific. Administered via injection, V181 works by stimulating the immune system to produce protective antibodies against dengue, including severe forms, regardless of prior exposure. The study aims the prevention of symptomatic and severe dengue, including hospitalization.
EYU688, developed by Novartis Pharmaceuticals, is an oral NS4B inhibitor targeting dengue virus replication. This Phase II study is recruiting 108 patients to examine the drug’s efficacy, safety, and pharmacokinetics in reducing dengue viral load, fever clearance time, and clinical symptoms compared with placebo. EYU688 works by inhibiting the viral NS4B protein, disrupting viral replication and reducing viremia, with demonstrated potency across DENV1 to DENV-4 strains. The study includes two parallel cohorts with intensive and sparse pharmacokinetic sampling to better understand drug absorption and metabolism. The results are expected to inform future therapeutic strategies for dengue fever.
AVX70120 is an investigational plasmid-based vaccine developed by AstriVax Therapeutics, designed for the prevention of Yellow Fever. This Phase I trial is recruiting healthy adults aged 18–40 to evaluate the safety, reactogenicity, and immunogenicity of AVX70120 and AVX70481 (rabies vaccine). Both vaccines are delivered via intramuscular injection and work by encoding viral antigens that stimulate robust immune responses, inducing high and durable antibody titers along with CD4 and CD8 T-cell activation. The study is examining multiple dose levels in a randomized, double-blind, placebo-controlled design, aiming to establish tolerability and optimal dosing for further development.
*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*
The Hemorrhagic Fever Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for hemorrhagic fever. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into hemorrhagic fever collaborations, regulatory environments, and potential growth opportunities.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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