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Report Overview

Severe acute respiratory syndrome has caused a significant global impact, with over 774 million confirmed COVID-19 cases and 7 million deaths reported by early 2025. According to Severe Acute Respiratory Syndrome pipeline analysis by Expert Market Research, ongoing development focuses on mRNA and protein-based vaccines, antivirals, and immunomodulators. These innovative therapies aim to improve prevention, reduce transmission, and enhance treatment outcomes. The pipeline reflects sustained scientific investment and strategic advancement to address emerging variants and evolving challenges in SARS coronavirus management worldwide.

  • Major companies involved in the severe acute respiratory syndrome pipeline analysis include BioNTech SE, Pfizer, and others.

  • Leading drugs currently in the pipeline include STX-S, Boost-2867 + Aluminum Hydroxide + CpG 7909, and others.

  • A key driver of the severe acute respiratory syndrome pipeline is the integration of variant-specific vaccine platforms, mRNA technology, and rapid antiviral development. Coupled with real-time genomic surveillance and improved immunomodulatory strategies, these innovations accelerate targeted therapeutic design, enabling faster responses to emerging SARS-CoV strains and expanding prophylactic and treatment options globally.

Report Coverage

The Severe Acute Respiratory Syndrome Pipeline Analysis Report by Expert Market Research gives comprehensive insights into severe acute respiratory syndrome therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for severe acute respiratory syndrome. The Severe Acute Respiratory Syndrome report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The Severe Acute Respiratory Syndrome pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with Severe Acute Respiratory Syndrome treatment guidelines to ensure optimal care practices.

The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to severe acute respiratory syndrome.

Severe Acute Respiratory Syndrome Pipeline Analysis by Drug Class

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Severe Acute Respiratory Syndrome Pipeline Outlook

The Severe Acute Respiratory Syndrome (SARS) pipeline outlook focuses on developing effective preventive and therapeutic options for coronavirus infections, including SARS-CoV-2. In May 2025, the U.S. FDA approved Nuvaxovid, a protein-based, adjuvanted COVID-19 vaccine, for active immunisation, protecting adults, including high-risk populations. This approval underscores ongoing innovation in vaccine technology, rapid adaptation to emerging variants, and expanded prophylactic options.

SARS treatments typically include antiviral agents, monoclonal antibodies, and supportive care, while vaccines remain the primary strategy for prevention. The pipeline continues to advance with novel antivirals, immunomodulators, and next-generation vaccines addressing evolving SARS coronavirus challenges.

Severe Acute Respiratory Syndrome Epidemiology

Severe Acute Respiratory Syndrome (SARS) represents a significant class of respiratory illnesses caused by coronaviruses, with SARS-CoV-2 emerging as the most impactful in recent history. The global outbreak that began in 2020 led to an unprecedented rise in infections, peaking in early 2022 with tens of millions of weekly reported cases. Reported case numbers declined through 2023 and 2024 as surveillance strategies increasingly relied on indicators such as hospitalisations and mortality rather than widespread diagnostic testing.

By March 2025, WHO reported that during a 28‑day period (6 Jan–2 Feb 2025) over 147,000 new cases occurred globally, representing a 16% decrease, while about 4,500 deaths were recorded (a 28% increase). Weekly PCR test positivity ranged from ~7.3% at the start of the period to ~5.0% at the end, across 103 countries. Several variants, including the JN.1 variant of interest and multiple variants under monitoring, continued to circulate, highlighting ongoing transmission and genomic evolution.

Severe Acute Respiratory Syndrome – Pipeline Therapeutic Assessment

This section of the report covers the analysis of severe acute respiratory syndrome drug candidates based on several segmentations, including:

By Phase

The pipeline assessment report covers 50+ drug analyses based on the phase:

  • Late-Stage Products (Phase 3 and Phase 4)
  • Mid-Stage Products (Phase 2)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

By Drug Class

The severe acute respiratory syndrome pipeline analysis report covers 50+ drug analyses based on drug classes:

  • Small Molecules
  • Monoclonal Antibodies
  • Immunomodulators
  • Vaccine Candidates

By Route of Administration

The pipeline assessment report covers 50+ drug analyses based on the route of administration:

  • Oral
  • Parenteral
  • Others

Severe Acute Respiratory Syndrome Pipeline Assessment Segmentation, By Phases

The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase II covers a major share of the total severe acute respiratory syndrome clinical trials. Phase II represents 44% of ichthyosis clinical trials, followed by Phase III (41%), with the remaining trials distributed across Phase I, Phase IV, and early-phase studies.

Severe Acute Respiratory Syndrome Pipeline Assessment Segmentation, By Drug Classes

The drug molecule categories covered under the severe acute respiratory syndrome pipeline analysis include small molecules, monoclonal antibodies, immunomodulators, and vaccine candidates. The severe acute respiratory syndrome report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for severe acute respiratory syndrome. In May 2025, the U.S. FDA approved mNEXSPIKE, an updated mRNA COVID‑19 vaccine specifically targeting emerging SARS-CoV-2 variants, enhancing protective coverage. This approval underscores continued innovation in vaccine technology, rapid response to viral evolution, and the expansion of prophylactic options. The pipeline continues to focus on broad-spectrum antivirals, immunomodulators, and next-generation vaccines to address unmet needs globally.

Severe Acute Respiratory Syndrome Clinical Trials – Key Players

The EMR report for the severe acute respiratory syndrome pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed severe acute respiratory syndrome therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in severe acute respiratory syndrome clinical trials:

  • GeoVax, Inc.
  • ModernaTX, Inc.
  • Novavax
  • BioNTech SE
  • Pfizer
  • Invivyd, Inc.
  • Gilead Sciences
  • AstraZeneca
  • Roche
  • Regeneron Pharmaceuticals

Severe Acute Respiratory Syndrome – Emerging Drugs Profile

This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for severe acute respiratory syndrome. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of severe acute respiratory syndrome drug candidates.

Biological: STX-S

STX-S is an investigational biological SARS-CoV-2 vaccine, classified as a preventive immunologic therapy. It works by stimulating the immune system to recognize SARS-CoV-2 antigens, activating both humoral (antibody-mediated) and cell-mediated immune responses to neutralize the virus and limit infection. This immune priming enables a faster and more effective response upon viral exposure, helping to reduce viral entry, replication, and potential disease severity. STX-S is administered as a vaccine and is designed to induce protective immunity rather than provide direct antiviral activity. The vaccine is being evaluated in a Phase I, interventional clinical trial assessing its safety, reactogenicity, and immunogenicity in adults, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), as part of early-stage clinical development for COVID-19 prevention.

Drug: Boost-2867 + Aluminum Hydroxide + CpG 7909

Boost-2867 is an investigational biological SARS-CoV-2 vaccine developed for the prevention of COVID-19 and formulated with Aluminum Hydroxide and CpG 7909 as immune-stimulating adjuvants, with Sodium Chloride 0.9% used as an excipient. The vaccine is designed to enhance immune responses against SARS-CoV-2 antigens by activating both innate and adaptive immunity, resulting in robust antibody and cell-mediated immune responses. Boost-2867 is administered via intranasal and intramuscular routes, allowing evaluation of both mucosal and systemic immunity. The vaccine is currently being evaluated in a Phase I, interventional clinical trial assessing its safety and immunogenicity in adults. The study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) and is expected to be completed on 24 November 2026, supporting early-stage clinical development of a preventive biological therapy for COVID-19.

Drug: SNG001

SNG001 is an inhaled interferon beta-1a therapy, classified as an antiviral immunomodulator. It works by activating the innate immune response in the respiratory tract, enhancing antiviral defences to reduce viral replication and lung inflammation during respiratory infections, including SARS-CoV-2. Administered via nebulization, SNG001 targets the lungs directly for a rapid therapeutic effect. The drug is developed by Synairgen plc, a UK-based biopharmaceutical company specialising in respiratory diseases, and has undergone multiple clinical trials evaluating its efficacy in hospitalised COVID-19 patients and other viral respiratory infections.

*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*

Key Questions Answered in the Severe Acute Respiratory Syndrome Pipeline Insight Report

  • Which companies/institutions are leading the severe acute respiratory syndrome drug development?
  • Which company is leading the severe acute respiratory syndrome pipeline development activities?
  • What is the current severe acute respiratory syndrome commercial assessment?
  • What are the opportunities and challenges present in the severe acute respiratory syndrome pipeline landscape?
  • What is the efficacy and safety profile of severe acute respiratory syndrome pipeline drugs?
  • Which company is conducting major trials for severe acute respiratory syndrome drugs?
  • Which companies/institutions are involved in severe acute respiratory syndrome collaborations aimed at providing enhanced therapeutic alternatives for patients?
  • What are the geographies covered for clinical trials in severe acute respiratory syndrome?

Reasons To Buy This Report

The Severe Acute Respiratory Syndrome Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for severe acute respiratory syndrome. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into severe acute respiratory syndrome collaborations, regulatory environments, and potential growth opportunities.

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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Scope of the Report

Details

Drug Pipeline by Clinical Trial Phase

  • Late-Stage Products (Phase III and Phase IV)
  • Mid-Stage Products (Phase II)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

Route of Administration

  • Oral
  • Parenteral
  • Others

Drug Classes

  • Small Molecules
  • Monoclonal Antibodies
  • Immunomodulators
  • Vaccine Candidate

Leading Sponsors Covered

  • GeoVax, Inc.
  • ModernaTX, Inc.
  • Novavax
  • BioNTech SE
  • Pfizer
  • Invivyd, Inc.
  • Gilead Sciences
  • AstraZeneca
  • Roche
  • Regeneron Pharmaceuticals

Geographies Covered

  • North America
  • Europe
  • Asia Pacific
  • Others

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