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Acute pyelonephritis is a severe bacterial infection of the kidneys and a significant contributor to the global burden of urinary tract infections. According to Jesús Redondo-Sánchez et al. (2025), it accounts for 5.5% of all UTIs treated in primary care and 14%–52% of hospital admissions for UTIs. As per acute pyelonephritis epidemiology forecast by Expert Market Research, the disease burden is expected to remain substantial due to increasing UTI incidence worldwide.
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Expert Market Research's “Acute Pyelonephritis Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of acute pyelonephritis. It projects the future incidence and prevalence rates of acute pyelonephritis cases across various populations. The study covers age, gender, and type as major determinants of the acute pyelonephritis population. The report highlights patterns in the prevalence of acute pyelonephritis over time and projects future trends based on multiple variables.
The report provides a comprehensive overview of the disease, as well as historical and projected data on the epidemiology of acute pyelonephritis in the 8 major markets.
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Acute pyelonephritis is a sudden and severe bacterial infection of the kidneys that typically arises from an ascending urinary tract infection. The condition commonly occurs when bacteria, most often Escherichia coli, spread from the bladder to the renal pelvis and kidney tissues. It causes inflammation that can impair kidney function if untreated. Symptoms frequently include high fever, flank pain, nausea, vomiting, and painful urination. Acute pyelonephritis may occur as uncomplicated or complicated forms, depending on underlying factors such as urinary tract obstruction, kidney stones, pregnancy, diabetes, or structural abnormalities of the urinary tract.
The acute pyelonephritis epidemiology division offers information on the patient pool from history to the present as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the acute pyelonephritis epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for acute pyelonephritis and their trends. The data is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

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The acute pyelonephritis epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.
The epidemiology of acute pyelonephritis varies across major healthcare regions but reflects a substantial clinical burden. According to Sayato Fukui et al., 2022, approximately 250,000 cases of acute pyelonephritis are diagnosed annually in the United States, leading to over 100,000 hospitalizations each year. In Japan, according to Ai Yamamoto et al., 2023, hospitalization incidence for urinary tract infections, including pyelonephritis, is reported at 6.8 per 10,000 men and 12.4 per 10,000 women, with an in-hospital mortality rate of 4.5%. Comparable healthcare systems in United Kingdom, Germany, France, Spain, Italy, and India also report notable hospitalization rates, reflecting the continued epidemiological significance of acute pyelonephritis across developed and emerging healthcare markets.
Treatment of acute pyelonephritis primarily involves prompt antibiotic therapy to eliminate the underlying bacterial infection. Oral antibiotics are commonly prescribed for mild to moderate cases, while severe infections may require intravenous antibiotics and hospitalization. Commonly used antibiotic classes include fluoroquinolones, cephalosporins, and beta-lactam antibiotics. Supportive care, such as adequate hydration, pain management, and antipyretic medications, helps relieve symptoms. In complicated cases caused by urinary obstruction, kidney stones, or structural abnormalities, medical procedures or surgical interventions may be required to restore urine flow and prevent recurrent infections or kidney damage.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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Base Year |
2025 |
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Historical Period |
2019-2025 |
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Forecast Period |
2026-2035 |
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