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Globally, nephrotic syndrome occurs in approximately 1.15–16.9 per 100,000 children annually and around 3 per 100,000 adults. The variation depends on ethnicity, geography, environmental factors, and diagnostic criteria. Men are affected slightly more often than women, a pattern seen consistently across studies. In pediatric populations, the male-to-female ratio is often 2:1 in early childhood, narrowing with age, whereas, in adults, incidence increases with age, reflecting the growing burden of systemic diseases (e.g., diabetes, hypertension).
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Expert Market Research's “Nephrotic Syndrome Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of nephrotic syndrome. It projects the future incidence and prevalence rates of nephrotic syndrome cases across various populations. The study covers age, gender, and type as major determinants of the nephrotic syndrome population. The report highlights patterns in the prevalence of nephrotic syndrome over time and projects future trends based on multiple variables.
The report provides a comprehensive overview of the disease, as well as historical and projected data on nephrotic syndrome epidemiology in the 8 major markets.
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Nephrotic syndrome is a kidney disorder characterized by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia. The causes include primary glomerular diseases such as minimal change disease, focal segmental glomerulosclerosis, and secondary conditions like diabetes, lupus, or infections. Patients often present with swelling around the eyes, legs, and abdomen, along with fatigue and increased susceptibility to infections and thromboembolic events. Untreated nephrotic syndrome may progress to chronic kidney disease. Early diagnosis and monitoring of kidney function are essential to manage symptoms and prevent complications, ensuring better long-term outcomes.
The nephrotic syndrome epidemiology division offers information on the patient pool from history to the present, as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the nephrotic syndrome epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for nephrotic syndrome and their trends. The nephrotic syndrome detailed epidemiology segmentation is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

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The nephrotic syndrome epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.
Globally, nephrotic syndrome remains a rare but significant kidney disorder, affecting both adults and children. The incidence of nephrotic syndrome in adults is approximately 3 per 100,000 people per year. North American and European countries are poised to witness stable-to-moderate growth due to controlled risk factors but aging populations. Asian countries like Japan, China and India will likely witness a growth 4–6% CAGR in the disease incidence due to increasing CKD prevalence and expanding healthcare access.
The condition manifests across all age groups, with slightly higher prevalence observed among males. Risk factors include underlying kidney diseases, infections, and genetic predispositions. Improved diagnostic capabilities and growing awareness have contributed to more accurate detection worldwide. Given its impact on kidney function and potential for progression to chronic kidney disease, nephrotic syndrome represents a critical focus for global healthcare monitoring and intervention.
The disease management involves treating underlying causes and controlling symptoms. Corticosteroids and immunosuppressive drugs reduce glomerular inflammation. ACE inhibitors or ARBs help lower proteinuria, while diuretics manage edema. Lipid-lowering agents address hyperlipidemia. Supportive care focuses on dietary modifications, infection prevention, and anticoagulation when indicated. Regular monitoring of kidney function and protein levels is necessary. Patient education on symptom recognition and adherence to therapy improves prognosis. Advances in biologics and novel therapies continue to enhance long-term management and reduce relapse risk.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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Base Year |
2025 |
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Historical Period |
2019-2025 |
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Forecast Period |
2026-2035 |
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