Amoxicillin Trihydrate Price Trend and Forecast 2026-2027

The US paid the most for amoxicillin trihydrate in Q2 2026: USD 30.1/KG, up 2.4% from USD 29.4 in Q1. The steady generic-antibiotic demand kept things firm there. Worldwide, the average moved up 2.1%, to USD 24.6/KG from USD 24.1, largely because the 6-APA feedstock costs kept climbing across every region we track. What about H2 2026? We'd expect a global average somewhere in the USD 24.3-26.4/KG range, with the steady generic-formulation demand doing most of the work.

Amoxicillin trihydrate is made from 6-aminopenicillanic acid, or 6-APA, condensed with D-(-)-p-hydroxyphenylglycine, then crystallized as the trihydrate salt that's stable enough for tablet and capsule manufacturing. It's one of the most widely prescribed antibiotics in the world, feeding oral formulations for respiratory, ear, and urinary-tract infections across every major healthcare system. Its role as a generic, off-patent workhorse means the demand tracks population health needs more than any single innovation cycle. Three things move the price more than anything else: the 6-APA feedstock costs, the generic-formulation demand from pharmaceutical manufacturers, and how much fermentation and API capacity the producers in China and India are running.

The 6-APA feedstock itself is worth understanding, since almost everything about this market traces back to it. It's made by enzymatically or chemically cleaving penicillin G, itself a fermentation product, and the economics of that fermentation step ripple all the way through to the finished amoxicillin price. Fermentation yields can vary with factors as mundane as ambient temperature at a production facility, which is part of why this market shows more quarter-to-quarter movement than you might expect from a decades-old, fully genericized antibiotic.

Seasonality plays a role too, though a modest one compared to some other pharmaceutical markets. Respiratory infection rates typically climb during colder months in the Northern Hemisphere, and that seasonal demand bump shows up as a mild but fairly consistent pattern in the Q4 and Q1 data across the markets we track, before easing back through the warmer months. Buyers who track this market closely tend to build that seasonal rhythm into their own purchasing calendars rather than treating each quarter's move as a fresh surprise.

Amoxicillin Trihydrate Price Forecast for 2026

Supply and demand should stay moderately tight through H2 2026, with the 6-APA feedstock costs doing most of the work on pricing. India and Italy both kept the generic-formulation demand steady through H1, and that's likely to continue. China's large API base should keep the supply ample even as the domestic and export demand both firm.

One structural factor worth flagging for buyers is how concentrated 6-APA production has become globally. A relatively small number of large fermentation facilities, mostly in China, supply the bulk of the world's 6-APA, and any disruption at one of those sites tends to ripple through amoxicillin pricing everywhere within a quarter or two.

Buyers negotiating longer-term supply agreements should factor in the modest seasonal demand pattern this market shows, since respiratory-infection rates and the associated prescription volumes typically climb during the colder months before easing back through the warmer stretch of the year.

What could push prices higher? A 6-APA feedstock spike, or a stronger-than-expected surge in generic-antibiotic demand. What could pull them lower? Expanded low-cost Chinese or Indian API capacity outpacing the demand.

For the Quarter Ending June 2026

Amoxicillin Trihydrate Prices Q2 2026:

• China: USD 20.1/KG
• India: USD 22.8/KG
• Italy: USD 26.8/KG
• United States: USD 30.1/KG

Amoxicillin Trihydrate Prices in China

China's amoxicillin trihydrate producers passed through the firmer 6-APA costs this quarter, and the domestic formulation demand held steady. The gain came to 2.0%, USD 19.7/KG to USD 20.1. That kept China the most affordable of the four markets by a comfortable margin.

Why did the price of Amoxicillin Trihydrate change in Q2 2026 in China?

The 6-APA feedstock costs firmed through the quarter, and the domestic generic-formulation demand held its ground right alongside that. Local manufacturers reported no real supply disruptions.

Amoxicillin Trihydrate Prices in India

India climbed 1.8% to USD 22.8/KG, the established generic-formulation demand staying firm through the period. Export volumes to regulated markets held steady as well.

Why did the price of Amoxicillin Trihydrate change in Q2 2026 in India?

The generic-formulation demand stayed firm, and the 6-APA feedstock costs climbed alongside it. Export orders to regulated markets held at their usual pace.

Amoxicillin Trihydrate Prices in Italy

Italy gained 1.9% to USD 26.8/KG, the European regulatory-grade demand continuing to hold steady through the period.

Why did the price of Amoxicillin Trihydrate change in Q2 2026 in Italy?

The European regulatory-grade demand held steady, and that alone explains most of the move here. Formulators reported no unusual buying patterns this quarter.

Amoxicillin Trihydrate Prices in United States

USD 30.1/KG. That's where the US landed in Q2, up 2.4% from USD 29.4 in Q1. The formulation demand stayed steady, and the feedstock costs climbed just enough to push things higher.

Why did the price of Amoxicillin Trihydrate change in Q2 2026 in United States?

The formulation demand didn't move much, honestly. It was the feedstock costs doing most of the work this quarter, tracking the broader 6-APA market closely.

For the Quarter Ending March 2026

Amoxicillin Trihydrate Prices Q1 2026:

• China: USD 19.7/KG
• India: USD 22.4/KG
• Italy: USD 26.3/KG
• United States: USD 29.4/KG

Amoxicillin Trihydrate Prices in China

China gained 2.1% to USD 19.7/KG, the demand firming as the year opened.

Why did the price of Amoxicillin Trihydrate change in Q1 2026 in China?

The domestic formulation demand firmed as the year opened, and the 6-APA feedstock costs edged higher right alongside it.

Amoxicillin Trihydrate Prices in India

India rose 2.3% to USD 22.4/KG, the formulation demand firming with the new year.

Why did the price of Amoxicillin Trihydrate change in Q1 2026 in India?

The generic-formulation demand firmed with the new year, and the feedstock costs kept climbing steadily too.

Amoxicillin Trihydrate Prices in Italy

Italy gained 2.3% to USD 26.3/KG, the regulatory-grade demand staying firm through the quarter.

Why did the price of Amoxicillin Trihydrate change in Q1 2026 in Italy?

The European regulatory-grade demand stayed firm, and the feedstock costs firmed alongside it.

Amoxicillin Trihydrate Prices in United States

US amoxicillin trihydrate rose 2.1% to USD 29.4/KG, the formulation demand building through the quarter.

Why did the price of Amoxicillin Trihydrate change in Q1 2026 in United States?

The formulation demand built through the quarter, tracking the prescription volumes closely.

Quarterly Amoxicillin Trihydrate Price Trends

The global average climbed steadily across the window, from USD 22.5/KG in Q1 2025 to USD 24.6 by Q2 2026, a net gain of about 9.3%. Every quarter posted a gain here, reflecting the firming 6-APA feedstock costs and the steady generic-formulation demand across every market we track, with a modest seasonal bump visible in the Q4 and Q1 figures each year. None of the four regions we cover broke from that broader pattern at any point during the window.

What was Amoxicillin Trihydrate Price in 2025?

2025 was a steadily firming year for amoxicillin trihydrate. Starting near USD 22.5/KG in Q1, the global average finished 2025 at USD 23.6, a gain of about 4.9%. The 6-APA feedstock costs firmed gradually all year, and the generic-formulation demand held dependable throughout, with the usual mild seasonal lift showing up in the colder-weather quarters.

Amoxicillin Trihydrate Prices in China in 2025

Chinese prices moved from about USD 18.5/KG in Q1 2025 to USD 19.3 by Q4, up roughly 4.3%. The domestic demand held steady all year, and China stayed the most affordable of the four markets throughout.

Amoxicillin Trihydrate Prices in India in 2025

Indian prices climbed from USD 21.0/KG in Q1 to USD 21.9 by Q4, a 4.3% gain, tracking the steady generic-formulation demand across every quarter.

Amoxicillin Trihydrate Prices in Italy in 2025

Italian prices rose from USD 24.5/KG in Q1 to USD 25.7 by Q4, up 4.9%, as the European regulatory-grade demand stayed firm through the year.

Amoxicillin Trihydrate Prices in United States in 2025

US prices moved from USD 27.5/KG in Q1 to USD 28.8 by Q4, a 4.7% gain, the highest absolute price throughout the four markets on the steady formulation demand.

How We Can Help

Expert Market Research: Your Source for Real-Time Amoxicillin Trihydrate Price Intelligence

We keep a continuous eye on the amoxicillin trihydrate prices wherever it's produced or consumed at scale, tracing causation through the 6-APA feedstock economics, the generic-formulation demand, and the API and fermentation capacity utilization across China and India. Our analysts revisit each of the four markets covered here every month, and we track the underlying 6-APA and penicillin G fermentation markets closely, since disruptions there tend to show up in amoxicillin pricing within a quarter or two. Need pricing data, bespoke market analysis, or procurement advisory? Reach out to our team.