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Amphotericin B Prices, Demand and Supply Overview
Amphotericin B prices in Germany, the highest-cost reporting region, rose 6.0% in H1 2026, climbing from USD 822/KG in Q1 to USD 871/KG by Q2 as recovering invasive fungal infection treatment, liposomal formulation, and hospital formulary procurement and firmer Streptomyces nodosus fermentation substrate costs reversed the brief Q3 2025 market dip. Globally, the average rose from USD 591.4/KG in Q1 to USD 626.9/KG in Q2, a 6.0% gain. For H2 2026, a global average of USD 631-700/KG is expected, with continued firming on growing invasive fungal infection, immunocompromised patient treatment, and antifungal access programme sector demand globally.
Amphotericin B is a polyene macrolide antifungal antibiotic produced by aerobic submerged fermentation of Streptomyces nodosus cultures in complex carbohydrate and nitrogen nutrient media, with the polyene macrolide extracted from fermentation broth by filtration and multi-step purification to pharmaceutical-grade active ingredient. The compound binds with high affinity to ergosterol in fungal cell membranes, forming aqueous pore channels that disrupt ionic gradients and membrane integrity, causing leakage and fungal cell death across a broad spectrum of clinically significant pathogenic fungi. The antifungal spectrum includes Candida species including fluconazole-resistant strains, Aspergillus, Cryptococcus neoformans, Mucorales, and dimorphic fungi including Coccidioides and Histoplasma. The largest pull comes from hospital treatment of invasive aspergillosis and candidiasis in haematology and ICU patients using liposomal or lipid complex formulations that reduce the nephrotoxicity of conventional deoxycholate preparations. Cryptococcal meningitis in HIV-positive patients, mucormycosis, and visceral leishmaniasis elimination programmes in South Asian and African endemic regions add significant further demand. Fermentation substrate costs, hospital formulary procurement, and regional API capacity all feed into the price.
Amphotericin B Price Forecast for 2026
The balance of supply and demand for Amphotericin B through H2 2026 leans moderately firm. Streptomyces nodosus fermentation substrate costs firmed from Middle East and agricultural supply disruptions. Invasive fungal infection treatment, immunocompromised patient care, and visceral leishmaniasis elimination programme procurement are growing with expanding haematology and intensive care capacity globally.
The main upside risk is fermentation substrate cost increases alongside accelerating hospital formulary and global health programme procurement. The main downside risk is continued generic API surplus and competitive antifungal alternatives limiting the global price recovery below forecast.
| Region | Price Forecast (USD/KG) | Key Driver |
| Global Average | 631 - 700 | Fermentation cost firming and invasive fungal/ICU demand support |
| United States | 676 - 745 | Steady invasive fungal and hospital formulary demand holds firm |
| China | 466 - 535 | Domestic fermentation capacity keeps it the most affordable |
| Germany | 878 - 947 | High fermentation and energy costs keep it the most expensive |
| India | 641 - 710 | Growing leishmaniasis and invasive fungal export demand holds firm |
For the Quarter Ending June 2026
Amphotericin B Prices Q2 2026:
- United States: USD 709/KG
- China: USD 489/KG
- Germany: USD 871/KG
- India: USD 671/KG
Amphotericin B Prices in the United States
US Amphotericin B prices averaged USD 709/KG in Q2 2026, up 6.0% from USD 669/KG in Q1 2026. Firmer fermentation substrate costs and recovering invasive fungal infection and hospital formulary procurement drove consistent buying through the quarter.
Why did the price of Amphotericin B change in Q2 2026 in the United States?
Firmer Streptomyces nodosus fermentation substrate costs raised the API production floor. Invasive aspergillosis, candidiasis, and mucormycosis liposomal formulation procurement lifted buying. Cryptococcal meningitis treatment demand provided additional buying support near USD 709/KG.
Amphotericin B Prices in China
Chinese Amphotericin B prices averaged USD 489/KG in Q2 2026, up 6.1% from USD 461/KG in Q1 2026, the lowest among the tracked markets. Spring invasive fungal infection and hospital formulary export and domestic procurement lifted buying. Firmer domestic fermentation substrate costs raised the floor despite domestic API capacity.
Why did the price of Amphotericin B change in Q2 2026 in China?
Spring invasive fungal and hospital formulary export and domestic procurement lifted buying. Firmer domestic fermentation substrate costs raised the production floor. Domestic fermentation capacity kept China the most affordable source.
Amphotericin B Prices in Germany
German Amphotericin B prices averaged USD 871/KG in Q2 2026, up 6.0% from USD 822/KG in Q1 2026, the highest among the tracked markets. Higher fermentation substrate and energy costs elevated European API production economics. Consistent invasive fungal infection, ICU, and hospital formulary demand maintained buying.
Why did the price of Amphotericin B change in Q2 2026 in Germany?
Higher Streptomyces nodosus fermentation substrate and energy costs elevated European API production economics. Middle East supply disruptions added cost premiums to fermentation substrate chains. Consistent invasive fungal infection and ICU hospital formulary procurement maintained buying near USD 871/KG.
Amphotericin B Prices in India
Indian Amphotericin B prices averaged USD 671/KG in Q2 2026, up 6.0% from USD 633/KG in Q1 2026. Growing visceral leishmaniasis elimination and invasive fungal infection export and domestic demand supported buying. Firmer fermentation import costs raised the floor.
Why did the price of Amphotericin B change in Q2 2026 in India?
Growing visceral leishmaniasis elimination and invasive fungal infection export and domestic procurement lifted buying. Firmer fermentation substrate import costs raised the production floor. Hospital formulary liposomal formulation export demand provided additional buying support near USD 671/KG.
For the Quarter Ending March 2026
Amphotericin B Prices Q1 2026:
- United States: USD 669/KG
- China: USD 461/KG
- Germany: USD 822/KG
- India: USD 633/KG
Amphotericin B Prices in the United States
US Amphotericin B prices averaged USD 669/KG in Q1 2026, recovering about 2.0% from Q4 2025. Recovering invasive fungal infection and hospital formulary demand and firming fermentation costs held the market near USD 669/KG.
Why did the price of Amphotericin B change in Q1 2026 in the United States?
Recovering invasive fungal infection and hospital formulary liposomal procurement maintained buying. Firming Streptomyces nodosus fermentation substrate costs raised the floor. The market recovered to USD 669/KG from the Q3 2025 level.
Amphotericin B Prices in China
Chinese prices averaged USD 461/KG in Q1 2026, recovering about 2.0% from Q4 2025. Post-Lunar New Year hospital and fungal infection restocking and firming fermentation costs held the market near USD 461/KG.
Why did the price of Amphotericin B change in Q1 2026 in China?
Post-Lunar New Year hospital formulary and invasive fungal infection restocking lifted buying. Firming domestic fermentation substrate costs raised the floor. The market recovered to USD 461/KG from the Q3 2025 level.
Amphotericin B Prices in Germany
German prices averaged USD 822/KG in Q1 2026, recovering about 2.0% from Q4 2025. Recovering invasive fungal and hospital formulary demand and firming fermentation and energy costs held the market near USD 822/KG.
Why did the price of Amphotericin B change in Q1 2026 in Germany?
Recovering invasive fungal infection and hospital formulary procurement maintained buying. Firming fermentation substrate and energy costs held the production floor. The market recovered to USD 822/KG from the Q3 2025 level.
Amphotericin B Prices in India
Indian prices averaged USD 633/KG in Q1 2026, recovering about 1.9% from Q4 2025. Growing visceral leishmaniasis and invasive fungal demand and firming import costs held the market near USD 633/KG.
Why did the price of Amphotericin B change in Q1 2026 in India?
Growing visceral leishmaniasis elimination and invasive fungal infection demand maintained buying. Firming fermentation import costs raised the production floor. The market recovered to USD 633/KG from the Q3 2025 level.
Quarterly Amphotericin B Price Trends
Global Amphotericin B prices dipped briefly in Q3 2025 on fermentation substrate cost softening before recovering through Q4 2025, Q1 2026, and Q2 2026. The average eased from USD 580.0/KG in Q2 2025 to USD 568.4/KG in Q3, then firmed to USD 579.8/KG in Q4, USD 591.4/KG in Q1 2026, and USD 626.9/KG in Q2 2026, a net gain of about 8.1% over the window. Streptomyces nodosus fermentation substrate cost cycles and invasive fungal infection and hospital formulary demand drove the consistent recovery pattern.
| Quarter | Price (USD/KG) | QoQ Change | Direction |
| Q2 2026 | 626.9 | +6.0% | ↑ Rising |
| Q1 2026 | 591.4 | +2.0% | ↑ Rising |
| Q4 2025 | 579.8 | +2.0% | ↑ Rising |
| Q3 2025 | 568.4 | -2.0% | ↓ Falling |
| Q2 2025 | 580.0 | - | - Stable |
| Q3 2026 | In Progress | - | - In Progress |
What was Amphotericin B Price in 2025?
Amphotericin B prices declined modestly through 2025 on fermentation substrate cost softening and moderate hospital formulary demand. The global average opened near USD 592/KG in Q1 2025 and closed at USD 579.8/KG in Q4, a marginal full-year decline of about 2.1%. Fermentation substrate dynamics and consistent invasive fungal infection treatment demand maintained stable conditions through the year.
Amphotericin B Prices in the United States in 2025
US prices fell from about USD 670/KG in Q1 2025 to USD 656/KG by Q4, a decline of 2.1%. Fermentation substrate cost softening and adequate API supply maintained the modest downward trend.
Amphotericin B Prices in China in 2025
Chinese prices fell from roughly USD 462/KG in Q1 2025 to USD 452/KG by Q4, a decline of 2.2%. Domestic fermentation capacity and competitive pricing maintained the lowest level throughout.
Amphotericin B Prices in Germany in 2025
German prices fell from about USD 824/KG in Q1 2025 to USD 806/KG by Q4, a decline of 2.2%. Fermentation substrate cost softening and moderate European invasive fungal demand maintained the trend.
Amphotericin B Prices in India in 2025
Indian prices fell from roughly USD 634/KG in Q1 2025 to USD 621/KG by Q4, a decline of 2.1%. Fermentation import cost softening maintained downward pressure through the year.
How We Can Help
Expert Market Research: Your Source for Real-Time Amphotericin B Price Intelligence
Expert Market Research tracks Amphotericin B prices continuously across every major producing and consuming region. The team traces causation through Streptomyces nodosus fermentation substrate economics, invasive fungal infection and hospital formulary procurement cycles, and regional API production capacity. Contact Expert Market Research today for Amphotericin B pricing data, bespoke market analysis, and strategic procurement advisory.
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Key Questions Answered in the Report
Hospital treatment of invasive aspergillosis and invasive candidiasis in haematology and intensive care patients using liposomal or lipid complex formulations takes the largest share. Cryptococcal meningitis treatment in HIV-positive patients, mucormycosis management, visceral leishmaniasis elimination in South Asian and African endemic regions, and coccidioidomycosis and histoplasmosis treatment also consume significant volumes globally.
The Q2 2026 average was USD 709/KG in the United States, USD 489/KG in China, USD 871/KG in Germany, and USD 671/KG in India. Germany remains the highest-priced market.
The global average rose from USD 591.4/KG in Q1 to about USD 626.9/KG in Q2, a gain of around 6.0%. Recovering invasive fungal infection and hospital formulary demand and firmer fermentation substrate costs drove the H1 firming from the Q3 2025 dip.
Streptomyces nodosus fermentation substrate cost softening reduced the API production floor. Seasonal hospital formulary and invasive fungal infection procurement moderation reduced buying urgency before the Q4 2025 and H1 2026 recovery.
The global average is expected in the USD 631 to 700/KG range for H2 2026, with continued firming as fermentation substrate costs stay elevated and invasive fungal infection and immunocompromised patient treatment demand grows globally.
Germany sits highest on fermentation and energy costs, the United States and India hold a firm middle on invasive fungal and hospital demand, and China prices lowest on domestic fermentation capacity.
This report is updated monthly. For real-time pricing intelligence, contact the Expert Market Research team directly.
Prices respond mainly to Streptomyces nodosus fermentation substrate costs, invasive fungal infection treatment guideline adoption, and hospital formulary procurement cycles. Fermentation substrate prices and immunocompromised patient population data are key signals.
China and India hold the largest Amphotericin B fermentation production capacity. Any fermentation substrate cost shift ripples across markets within one to two quarters.
Buyers can use quarterly trends and forecasts to time hospital formulary and liposomal formulation contracts around fermentation cost cycles, build cover when substrate signals tighten, and monitor invasive fungal infection incidence data as primary signals.
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