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The anaphylaxis treatment market was valued at USD 2.32 Billion in 2025 and is expected to grow at a CAGR of 6.40%, reaching USD 4.31 Billion by 2035. The market growth is driven by the rising incidence of allergies and food-related anaphylactic reactions, as well as increasing awareness and accessibility of epinephrine auto-injectors and emergency medical care across the 8 major markets. The market is fueled by the increasing availability of advanced epinephrine delivery devices and growing public awareness. Rising healthcare spending and improved emergency response infrastructure are expected to support market expansion.
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In February 2024, the FDA approved Xolair to reduce allergic reactions, including the risk of anaphylaxis, from accidental exposure to multiple foods, an advancement expected to significantly boost anaphylaxis treatment market growth.
Factors such as rising prevalence of food, drug, and insect–triggered anaphylaxis, combined with increased public awareness initiatives, government mandates, and innovations in delivery formats are accelerating market expansion
The market growth is further propelled by the involvement of various stakeholders, including pharmaceutical firms, biotech innovators, and device manufacturers, who are enhancing treatment efficacy, affordability, and global accessibility.
Anaphylaxis treatment involves prompt administration of epinephrine, followed by supportive care such as antihistamines, corticosteroids, and oxygen therapy to stabilize the patient and prevent recurrence. Rapid response is critical to reduce the risk of complications and fatal outcomes. The market is witnessing growth due to rising allergy prevalence, increased awareness, and improved access to emergency care. The market was valued at USD 2.32 Billion in 2025 and is expected to expand with advancements in auto-injector technology and broader distribution channels. Supportive government initiatives and increasing incidence of anaphylactic reactions further drive market demand across developed and emerging economies.
Rising Incidence of Anaphylaxis to Enhance Market Growth
The increasing prevalence of anaphylaxis is a significant growth driver of the treatment market. According to Kevin McLendon et al. 2023, the incidence of anaphylaxis in the United States doubled over the past two decades, with approximately 1,500 deaths reported annually. This alarming rise underscores the urgent need for effective emergency treatments and preventive therapies. Consequently, the demand for epinephrine auto-injectors and advanced biologics is projected to drive consistent market expansion.
Key trends in the market include the rise of needle-free innovations and the growing adoption of epicutaneous immunotherapy.
Needle-Free Innovations Driving Growth in the Market
The market is experiencing a notable shift toward innovative, patient-friendly solutions, particularly needle-free drug delivery systems. This trend addresses key concerns around needle phobia and delays in emergency treatment. For instance, in February 2025, ARS Pharmaceuticals advanced this movement by filing for the approval of neffy®, a needle-free epinephrine nasal spray, in Canada and the UK, following its 2024 approval in the U.S. and Europe. As acceptance of non-invasive treatments expands, this trend is expected to significantly boost global market growth.
Epicutaneous Immunotherapy Emerging as a Game-Changer in Pediatric Allergy Management and Boost Anaphylaxis Treatment Market Demand
A notable trend in the market is the development of innovative, non-invasive therapies targeting pediatric food allergies. In February 2025, DBV Technologies announced promising results from a three-year study of the VIASKIN® Peanut patch, showing improved peanut tolerance and sustained safety in toddlers. This advancement in epicutaneous immunotherapy signals strong potential to transform long-term allergy care and is expected to significantly boost market growth.
Food Allergies to Lead the Market Share Based on Allergen Type
There are several allergens that can trigger life-threatening anaphylactic reactions, including food, insect stings, medications, and other environmental factors. In the anaphylaxis treatment market, segmentation by allergen type includes food allergies, insect allergies, drug allergies, and others. Among these, food allergies are expected to lead the market due to their rising global prevalence and increasing public health burden. According to the Food Allergy Research and Education (FARE) organization, approximately 33 million people in the United States alone have at least one food allergy. Notably, nearly 11% of U.S. adults, over 27 million individuals report suffering from food allergies. This rising incidence significantly drives the demand for rapid and effective treatment options, positioning food allergies as the dominant segment in the anaphylaxis treatment market.
The market is divided into regions such as the United States, the United Kingdom, Germany, France, Italy, Spain, Japan, and India. Among these, the United States remains dominant, bolstered by a robust healthcare infrastructure, strong regulatory support, and ongoing innovation. Notably, in June 2025, the FDA accepted Aquestive Therapeutics’ New Drug Application for Anaphylm, a sublingual epinephrine film for treating anaphylaxis and other type 1 allergic reactions. As a needle‑free, ultra‑portable alternative to traditional autoinjectors, Anaphylm addresses critical issues of compliance, convenience, and patient accessibility. This development underscores the United States’ position at the forefront of anaphylaxis treatment advancements.
The anaphylaxis treatment market research report by Expert Market Research provides an in-depth analysis of the competitive landscape, offering key insights into patent filings, grant analysis, funding trends, investments, and strategic initiatives by major players. It tracks recent investments, mergers, acquisitions, and partnerships that showcase the market's growth trajectory. Additionally, the report details strategic activities by leading companies, including regional expansions, adoption of new technologies, and efforts to enhance capacity, helping stakeholders better understand the market dynamics and positions of key industry players. Some of the leading players are as follows:
Viatris Inc., a prominent healthcare company, is actively involved in the anaphylaxis treatment market through its widely recognized EpiPen® and EpiPen® Jr. auto-injectors. These adrenaline-based emergency devices are indicated for the rapid treatment of severe allergic reactions triggered by foods, insect bites, drugs, or other allergens. Viatris continues to play a critical role in providing immediate, life-saving intervention for patients at risk of anaphylactic episodes.
Novartis AG has strengthened its position in the anaphylaxis treatment market with the FDA approval of Xolair® (omalizumab) for children and adults with IgE-mediated food allergies. Xolair, developed in collaboration with Genentech, is the first and only FDA-approved biologic to reduce allergic reactions, including anaphylaxis, from accidental food exposure. This approval marks a critical advancement in long-term allergy management.
Amgen Inc. is actively involved in the market through its biologic therapy, KRYSTEXXA® (pegloticase), primarily indicated for adults with uncontrolled gout. Recent data from the Phase 4 AGILE trial presented at ACR 2024 highlighted a 1.7% incidence of anaphylaxis in patients receiving shorter infusion durations. These findings underscore Amgen’s continued commitment to advancing safe and effective treatment options for complex inflammatory conditions.
Amneal Pharmaceuticals LLC, through its division Impax Laboratories, is actively involved in the anaphylaxis treatment market with its epinephrine injection, USP auto-injector. This product, the authorized generic of Adrenaclick®, is available in 0.15 mg and 0.3 mg doses and is currently distributed in pharmacies across the United States. Designed for emergency treatment of anaphylactic reactions, the auto-injector offers a low-cost, reliable alternative for patients and caregivers, reinforcing Amneal’s commitment to accessible, life-saving therapeutics.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other key players in the market include AstraZeneca plc, Pfizer Inc., Teva Pharmaceutical Industries Ltd., Merck and Co., Inc., and Glaxosmithkline Plc.
The market report offers a detailed analysis of the market based on the following segments:
Market Breakup by Allergen Type
Market Breakup by Drug Class
Market Breakup by Route of Administration
Market Breakup by Age Group
Market Breakup by Distribution Channel
Market Breakup by Region
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Allergen Type |
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| Breakup by Drug Class |
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| Breakup by Route of Administration |
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| Breakup by Age Group |
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| Breakup by Distribution Channel |
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| Breakup by Region |
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| Market Dynamics |
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