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Report Overview

2024

Base Year

2018-2024

Historical Year

2025-2034

Forecast Year

Hepatic Encephalopathy Treatment Market Outlook

The hepatic encephalopathy treatment market size was valued at USD 1.6 billion in 2024, driven by the rising incidence of liver cirrhosis across the 7 major markets. The market is expected to grow at a CAGR of 5.7% during the forecast period of 2025-2034, with the values likely to rise from USD 1.7 billion in 2025 to USD 2.6 billion by 2034.

Hepatic Encephalopathy Treatment: Introduction

Hepatic encephalopathy is a temporary neurological disorder that occurs due to a severe liver disease. The damaged liver fails to clear out the toxins effectively and toxins build up reaches the brain through the blood stream. It causes cognitive impairment and affects brain function. Hepatic encephalopathy is commonly managed by antibiotics and laxatives. However, the treatment may vary depending upon the symptoms and overall health of the patient.

Hepatic Encephalopathy Treatment Market Analysis

The hepatic encephalopathy treatment market demand is mostly driven by the increasing prevalence of liver-associated diseases which include liver cirrhosis, hepatitis, and fatty liver.

Nonabsorbable disaccharides, such as lactulose or lactitol, are considered as the first in-line treatment for the condition. They function by lowering the absorption of ammonia in the body. Another commonly used treatment method is the use of antibiotics. They are used to alter the gut microbiota to create a more favourable microbiome that leads to decreased endogenous bacterial production of ammonia. Rifaximin, Neomycin and Metronizadole are frequently prescribed to treat the condition.

Dietary treatment alternatives that naturally lower down the ammonia levels in the body can also be applied. Using intravenous L-ornithine-L-aspartate has been proven helpful in lowering the severity of the condition in some patients. If the condition persists due to complete liver damage, then liver transplant is the last alternative recommended by healthcare professionals.

Apart from pharmaceuticals, the hepatic encephalopathy treatment market value is also driven by the rising advancements in diagnostics. Tests like electroencephalography are used to determine the severity of the condition and facilitate effective treatment based on it.

Hepatic Encephalopathy Treatment Market Segmentation

Market Breakup by Drug Class

  • Antibiotics
  • Laxatives
  • L-ornithine
  • L-aspartate
  • Others

Market Breakup by Diagnosis

  • Blood Tests
  • CT Scan
  • Liver Functioning Tests (LFT)
  • Others

Market Breakup by Treatment

  • Medication
  • Surgery
  • Others

Market Breakup by Route of Administration

  • Oral
  • Injectable
  • Intravenous
  • Rectal
  • Others

Market Breakup by End User

  • Hospitals
  • Homecare
  • Speciality Clinics
  • Others

Market Breakup by Distribution Channels

  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy
  • Others

Market Breakup by Region

  • United States
  • EU-4 and the United Kingdom
    • Germany
    • France
    • Italy
    • Spain
    • United Kingdom
  • Japan

Hepatic Encephalopathy Treatment Market Overview

The United States has been proactive in mitigating the rising burden of liver diseases. The region has held a substantial percentage of the hepatic encephalopathy treatment market share. With increasing drug development and other treatment alternatives, there has been significant emphasis on educating the population on identifying the early stages of liver damage. This has been made possible through awareness campaigns and initiatives set up by government as well as private institutions. In July 2023, the World Health Organization launched “One Life, One Liver” campaign, aimed at protecting liver health.

Alcohol consumption, obesity and sedentary lifestyle are major factors contributing to liver diseases. Hence, Europe is also a significant player of the hepatic encephalopathy treatment market. With well-equipped medical infrastructure and staff, it can pioneer the treatment market by bringing groundbreaking innovations to improve the efficacy of medicines.

With a high percentage of geriatric population, the Asia Pacific region is expected to witness rapid hepatic encephalopathy treatment market growth in the coming years. The region has been experiencing major mergers and acquisitions among impactful companies, which are anticipated to fuel market growth. With an influx of foreign investments, the medical infrastructure is also improving.

Hepatic Encephalopathy Treatment Market: Competitor Landscape

The key features of the market report include patent analysis, grants analysis, clinical trials analysis, funding and investment analysis, partnerships, and collaborations analysis by the leading key players. The major companies in the market are as follows:

  • Salix Pharmaceuticals
  • Mallinckrodt plc.
  • Merck & Co., Inc.
  • Bausch Health
  • Takeda Pharmaceutical Company Limited
  • Johnson & Johnson Services, Inc.
  • Eisai Co., Ltd
  • AbbVie Inc.
  • Hikma Pharmaceuticals PLC
  • Vedanta Biosciences
  • Patricia Bloom
  • Umecrine Cognition
  • Axcella Health Inc.
  • Pfizer Inc.
  • Rebiotix

Kindly note that this only represents a partial list of companies, and the complete list has been provided in the report.

Key Highlights of the Report

REPORT FEATURES DETAILS
Base Year 2023
Historical Period 2018-2024
Forecast Period 2025-2034
Scope of the Report

Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:

  • Drug Class
  • Diagnosis
  • Treatment
  • Route of Administration
  • End User 
  • Distribution Channels 
  • Reguonal
Breakup by Drug Class
  • Antibiotics    
  • Laxatives
  • L-ornithine  
  • L-aspartate  
  • Others 
Breakup by Diagnosis
  • Blood Tests    
  • CT Scan    
  • Liver Functioning Tests (LFT)    
  • Others 
Breakup by Treatment
  • Medication  
  • Surgery
  • Others 
Breakup by Route of Administration
  • Oral
  • Injectable  
  • Intravenous  
  • Rectal  
  • Others  
Breakup by End User 
  • Hospitals 
  • Homecare
  • Speciality Clinics 
  • Others 
Breakup by Distribution Channels 
  • Hospital Pharmacy  
  • Retail Pharmacy  
  • Online Pharmacy 
  • Others 
Breakup by Region
  • United States
  • EU-4 and the United Kingdom
  • Japan
Market Dynamics
  • Market Drivers and Constraints
  • SWOT Analysis
  • Porter’s Five Forces Model 
  • Key Demand Indicators
  • Key Price Indicators
  • Industry Events, Initiatives, and Trends 
  • Value Chain Analysis
Competitive Landscape
  • Market Structure
  • Company Profiles
    • Financial Analysis
    • Product Portfolio
    • Demographic Reach and Achievements
    • Mergers and Acquisitions
    • Certifications
Companies Covered
  • Salix Pharmaceuticals
  • Mallinckrodt plc.
  • Merck & Co., Inc. 
  • Bausch Health
  • Takeda Pharmaceutical Company Limited 
  • Johnson & Johnson Services, Inc.
  • Eisai Co., Ltd
  • AbbVie Inc.
  • Hikma Pharmaceuticals PLC
  • Vedanta Biosciences
  • Patricia Bloom
  • Umecrine Cognition
  • Axcella Health Inc.
  • Pfizer Inc.
  • Rebiotix

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Key Questions Answered in the Report

The market attained a value of about USD 1.6 billion in 2024, driven by rising incidence of liver cirrhosis.

The market is anticipated to grow at a CAGR of 5.7% during the forecast period of 2025-2034, likely to reach a market value of USD 2.6 billion by 2034.

The market demand is driven by increasing burden of liver diseases and increasing alcohol consumption around the 7 major markets.

The key trends which are bolstering the market growth include the increasing focus on combination therapies and increasing drug approvals for treating hepatic encephalopathy.

The drug classes in the market include antibiotics, laxatives, L-ornithine, and L-aspartate, among others.

The treatments in the market are blood tests, CT scan, and liver functioning tests (LFT), among others.

The different routes of administration are oral, injectable, intravenous, and rectal, among others.

The end-users in the market are hospitals, homecare, and specialty clinics, among others.

The distribution channels available in the market are hospital pharmacy, retail pharmacy, and online pharmacy, among others.

The major regions of the market include the United States, Japan, EU-4 and the United Kingdom. EU-4 comprises of Germany, France, Italy, and Spain.

Key players involved in the market are Salix Pharmaceuticals, Mallinckrodt plc., Merck & Co., Inc., Bausch Health, Takeda Pharmaceutical Company Limited, Johnson & Johnson Services, Inc., Eisai Co., Ltd, AbbVie Inc., Hikma Pharmaceuticals PLC, Vedanta Biosciences, Patricia Bloom, Umecrine Cognition, Axcella Health Inc., Pfizer Inc., and Rebiotix.

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