Report Overview

The global nucleic acid therapeutics market was valued at USD 4.26 billion in 2023 driven by advancements in genomic technologies across the globe. It is projected to grow at a CAGR of 12.84% during the forecast period of 2024-2032 and attain a market value of USD 12.63 billion by 2032.

2023

Base Year

2017-2023

Historical Year

2024-2032

Forecast Year

Nucleic Acid Therapeutics Market Outlook

  • The rising incidences of genetic disorders and other chronic diseases, including cystic fibrosis, muscular dystrophy, cancer, and heart diseases, are fueling the growth of the market.
  • In August 2023, CureVac N. V. and GSK launched a phase II trial for monovalent and bivalent COVID-19 vaccines based on mRNA. This shows ongoing research, development, and investment in markets and the development of nucleic acid based medications.
  • North America is expected to hold the largest market share for nucleic acid therapeutics mainly because of high R&D investments, advanced facilities, and support from the regulatory bodies. The presence of major biotech firms and their focus on developing personalized medicine promotes the use of innovative nucleic acid therapies, thus benefiting the market.

Nucleic Acid Therapeutics Market Overview

Nucleic acid therapeutics utilize either synthetic or natural nucleic acids to control gene expression and address multiple ailments. ASOs, siRNAs, miRNAs, aptamers, and CRISPR/Cas9 are some of the common technologies used in this treatment. They provide a focused method for managing diseases, enabling accurate genetic intervention, particularly helpful for diseases with identifiable genetic causes like rare genetic disorders, cancers, and viral infections.

Nucleic Acid Therapeutics Market Growth Drivers

Increasing Prevalence of Genetic Disorders and Chronic Diseases Boost the Market Growth

The rising prevalence of genetic disorders, and other diseases, such as cystic fibrosis, muscular dystrophy, cancer, cardiovascular diseases, metabolic syndrome, and others are the primary factors boosting the market growth. Aberrations of DNA sequences and gene expression are often observed in these indications, for which nucleic acid therapies are a suitable solution, providing effective treatment to a wider section of the population. This is leading to an increased application of nucleic acid therapeutics, intended to combat the burden of rising morbidities.

Advancements in Genomic Technologies and Personalized Medicine to Meet Rising Nucleic Acid Therapeutics Market Demand
Advanced technologies in nucleic acid therapeutics include NGS, CRISPR/Cas9 gene editing, and bioinformatics which has further advanced the progress of these therapeutics. This makes it easier to diagnose the mutation in genes and get the right treatment for the individuals affected. The market growth is driven by the increasing demand for personalized treatments, where treatments and medications are based on a person’s genetic profile.

Increase in Clinical Trial and Research Initiatives

In August 2023, CureVac N.V. and GSK initiated a Phase 2 trial in Australia for their single and double-modified mRNA COVID-19 vaccine candidates. The study's goal is to evaluate the safety, reactogenicity, and immune responses in 415 healthy adults after successful Phase 1 results for a comparable vaccine designed for the omicron BA.1 variant.

In March 2022, Moderna, Inc. tested an experimental HIV trimer mRNA vaccine (mRNA-1574) in around 100 HIV-negative adults in a Phase 1 clinical trial. The NIAID-sponsored trial within the NIH aimed to evaluate the safety and immunogenicity of the vaccine. An NIAID grant funded the development of the vaccine, with assistance from Scripps Research and IAVI.

Nucleic Acid Therapeutics Market Trends

Integration with Nanotechnology Enhancing Market Growth

Nanotechnology is expanding the market through improvements in the delivery, stability, and performance of nucleic acid therapeutic agents. The use of lipid nanoparticles for delivery of siRNAs and mRNA vaccines in order to resist the degradation of nucleic acids is amongst the major market trends.

Expanding Applications in Oncology Boosting Market Adoption

Nucleic acid therapeutics are being increasingly employed in oncology because they can address specific cancer-related genes and signaling cascades. Techniques like antisense oligonucleotides, small interfering RNA (siRNAs), and CRISPR/Cas9 are being employed to silence oncogenes and related mutations. Such advancements are anticipated to revolutionize precision oncology, by offering personalized treatments.

Regulatory Approvals and Collaborations Enhancing Market Expansion

The nucleic acid therapeutics market is expanding due to the approval and collaborations through existing agencies such as the FDA and EMA. New drugs include Spinraza, a spinal muscular atrophy treatment, and Onpattro for transthyretin-mediated hereditary amyloidosis. These affiliations are expected to enhance the rate of development of more therapies and innovation. In September 2022, Alnylam Pharmaceuticals received the marketing approval for AMVUTTRA by the European Commission. It is an RNAi therapy for adults with stage 1 or 2 polyneuropathy caused by hereditary transthyretin-mediated amyloidosis. The authorization comes after promising 18-month findings from the HELIOS-A Phase 3 trial, with more than half of patients experiencing a stop or improvement in polyneuropathy symptoms. AMVUTTRA provides subcutaneous administration every three months or possibly twice a year.

Increasing Investment in Research and Development Driving Market Growth

The market is growing because of increased funding for research and development. There is a focus on investing in the development and identification of new drugs by pharmaceutical enterprises, biotechnology businesses, and educational establishments. It is also supported by government funding and grants for such enhancing initiatives and holds great promise for genetic disorders, cancers, chronic diseases, and others.

Nucleic Acid Therapeutics Market Segmentation

Market Breakup by Product Type

  • RNA Interference [RNAi] and Short Interfering RNAs [siRNAs]
  • Antisense Oligonucleotides (ASOs)
  • Others

Market by Indication

  • Oncology 
  • Infectious Diseases 
  • Prenatal Diagnostics 
  • Transplantation 
  • Cardiovascular Disorders 
  • Others

Market Breakup by End User

  • Hospitals
  • Research and Academic Institutes
  • Others

Market Breakup by Region

  • North America
  • Europe 
  • Asia Pacific
  • Latin America
  • Middle East and Africa

Nucleic Acid Therapeutics Market Share

Market Segmentation Based on End User Set to Witness Substantial Growth

Based on the end user, the market is divided into hospitals, research and academic institutes, and others. Among these, the market is expected to be dominated by research laboratories due to the rising demand for nucleic acid research and treatment interventions. These labs discover new medications and technologies, thereby nurturing new ideas for broadening their applications. Due to the tremendous interest in genetics and molecular targeted therapies, more research institutes and biotechnology companies are anticipated to adopt these technologies and impact the market landscape significantly.

Nucleic Acid Therapeutics Market Analysis by Region

Based on regions, the market report covers North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa. North America is expected to dominate the market, driven by an immense focus on providing investments to conduct research. In addition, the presence of technically advanced infrastructure also impacts the market value positively.

European nucleic acid market comes next as a region with high regard for innovation, and noteworthy support from the healthcare regulatory authorities, aiding the implementation of neurotechnology. Growth in developing countries, especially in Asia Pacific, due to economic development, higher healthcare expenditure, and a rising population of patients suffering from genetic and chronic diseases, is encouraging market growth.

Leading Players in the Nucleic Acid Therapeutics Market

The key features of the market report include patent analysis, clinical trials analysis, grants analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies are:

Copernicus Therapeutics Inc.

Established in 1995 and headquartered in Ticino, Switzerland, the company has a diversified product line concerning nucleic acid therapeutics. This clinical stage biopharmaceutical company has a key emphasis on leveraging gene therapy to treat rare diseases.

Silence Therapeutics PLC

Founded in 1994, the company has a presence across the United States, United Kingdom and other parts of Europe. The company is building a robust siRNAs-based pipeline for various diseases including rare diseases like Polycythemia Vera (PV) and other cardiovascular diseases. It is focused on using its mRNAi GOLD™ platform to develop innovative technologies for precise drug development.

Other companies include Sanofi S.A., Thermo Fisher Scientific Inc., Sarepta Therapeutics, Inc., Novartis AG, Merck & Co., Inc., Alnylam Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., and Arrowhead Pharmaceuticals, Inc.

Key Questions Answered in the Nucleic Acid Therapeutics Market

  • What was the global nucleic acid therapeutics market value in 2023?
  • What is the global nucleic acid therapeutics market forecast outlook for 2024-2032?
  • What are the regional markets covered in the EMR report?
  • What is the market segmentation based on the indication?
  • What is the market breakup based on product type?
  • What is the market breakup based on the end user?
  • What are the major factors aiding the global nucleic acid therapeutics market demand? 
  • What are the market's major drivers, opportunities, and restraints? 
  • Which regional market is expected to lead the market share in the forecast period? 
  • Which country is expected to experience expedited growth during the forecast period? 
  • What are the major global nucleic acid therapeutics market trends?
  • How does the rise in the geriatric population impact the market size?
  • Who are the key players involved in the nucleic acid therapeutics market?
  • What are the current unmet needs and challenges in the market?
  • How are partnerships, collaborations, mergers, and acquisitions among the key market players shaping the market dynamics?
  • What are the key applications within the market, and how do they influence patient outcomes?
  • Which products lead the nucleic acid therapeutics market, and what factors contribute to their widespread adoption?
  • Which methods are most frequently utilized in the nucleic acid therapeutics market?
  • What are the driving forces behind the market's performance in North America?
  • What are the unique market dynamics in Europe, and how do they compare to other regions?

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

REPORT FEATURES DETAILS
Base Year 2023
Historical Period 2017-2023
Forecast Period 2024-2032
Scope of the Report

Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:

  • Product Type
  • Indication
  • End User
  • Region
Breakup by Product Type
  • RNA Interference [RNAi] and Short Interfering RNAs [siRNAs]
  • Antisense Oligonucleotides (ASOs)
  • Others
Breakup by Indication
  • Oncology
  • Infectious Diseases
  • Prenatal Diagnostics
  • Transplantation
  • Cardiovascular Disorders
  • Others
Breakup by End User
  • Hospital and Clinics
  • Research and Academic Institute
  • Others
Breakup by Region
  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East and Africa
Market Dynamics
  • Market Drivers and Constraints
  • SWOT Analysis
  • PESTEL Analysis
  • Porter’s Five Forces Model 
  • Key Demand Indicators
  • Key Price Indicators
  • Industry Events, Initiatives, and Trends 
  • Value Chain Analysis
Supplier Landscape
  • Market Structure
  • Company Profiles
    • Financial Analysis
    • Product Portfolio
    • Demographic Reach and Achievements
    • Company News and Developments
    • Certifications
Companies Covered
  • Copernicus Therapeutics Inc.
  • Silence Therapeutics  PLC
  • Sanofi  S.A.
  • Thermo Fisher Scientific  Inc.
  • Sarepta Therapeutics, Inc.
  • Novartis AG
  • Merck & Co., Inc.
  • Alnylam Pharmaceuticals, Inc.
  • Ionis Pharmaceuticals, Inc.
  • Arrowhead Pharmaceuticals, Inc.

 

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