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Report Overview
The RNA therapeutics market was valued at USD 15.28 Billion in 2025. It is poised to grow at a CAGR of 5.60% during the forecast period of 2026-2035, and reach USD 26.35 Billion by 2035. The market growth is driven by the increasing prevalence of genetic disorders, the rising adoption of mRNA technologies, expanding vaccine applications, and growing investment in precision medicine research globally.
Latest News on the RNA Therapeutics Market (2026)
- In April 2026, Moderna, Inc. initiated a late-stage clinical trial for its mRNA-1018 bird flu vaccine across the United States and the United Kingdom.
- In February 2026, the European Medicines Agency recommended approval of Moderna’s combined COVID-19 and influenza vaccine, advancing next-generation mRNA-based combination vaccine development.
- In December 2025, Alnylam Pharmaceuticals, Inc. announced a USD 250 million investment to expand its RNAi manufacturing facility, strengthening global production capacity.
Key Market Trends and Insights
- By type, mRNA commanded over 35% of the market share in the historical period.
- By indication, infective diseases segment commanded about 50% of the market share in the historical period.
- By region, North America commanded above 45% of the market share in the historical period.
Market Size and Forecast
- Market Size (2025): USD 15.28 Billion
- Projected Market Size (2035): USD 26.35 Billion
- CAGR (2026-2035): 5.60%
Compound Annual Growth Rate
5.6%
Value in USD Billion
2026-2035
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RNA Therapeutics Market Overview
The market is expanding rapidly due to the increasing adoption of advanced RNA-based modalities for targeted disease treatment. Innovations in mRNA therapy, siRNA, antisense oligonucleotide, miRNA mimic, ribozyme, and aptamer technologies are enhancing precision medicine. Growing applications in of mRNA therapy is transforming drug discovery pipelines, improving therapeutic efficacy, and supporting expansion of next-generation RNA-based treatment platforms globally across multiple disease areas. The market reached a value of approximately USD 15.28 Billion in 2025.
RNA Therapeutics Market Growth Drivers
Clinical Advancements Strengthening RNA Therapeutics Market Innovation
Increasing demand for rapid-response vaccines and expanding late-stage pipelines are shaping market growth. For instance, in April 2026, Moderna, Inc. initiated a late-stage clinical trial for its mRNA-1018 bird flu vaccine across the United States and the United Kingdom, marking a significant milestone in pandemic preparedness. This advancement is accelerating the adoption of mRNA therapy, reinforcing pipeline maturity and supporting long-term market expansion.
RNA Therapeutics Market Trends
Key trends shaping the market include rapid mRNA innovation, expanding clinical pipelines, increasing regulatory approvals, and growing investment in RNA-based therapeutics globally.
Strategic Investments Supporting RNA Therapeutics Market Development and Commercialization
Growing investment in manufacturing capacity and increasing demand for scalable production are driving market expansion. For instance, in December 2025, Alnylam Pharmaceuticals, Inc. announced a USD 250 million investment to expand its RNAi manufacturing facility, enhancing production capacity and reducing costs for future therapies. This initiative is strengthening commercialization of siRNA therapeutics and supporting broader global market development.
RNA Therapeutics Market Segmentation
Market Breakup by Product
- Vaccines
- Drugs
Market Breakup by Type
- mRNA Therapeutics
- RNA Interference (RNAi) Therapeutics
- Antisense Oligonucleotide (ASO) Therapeutics
- Others
Market Breakup by Indication
- Infective Diseases
- Rare Genetic Diseases/Hereditary Diseases
- Others
Market Breakup by End User
- Hospitals and Clinics
- Research Settings
- Others
Market Breakup by Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East and Africa
RNA Therapeutics Market Share
Infective Disease Expected to Dominate the Market Segment by Indication
The infective diseases segment continues to dominate the market, driven by strong vaccine demand and expanding antiviral pipelines. In the historical period, it accounted for over 50% share, supported by rapid advancements in RNA technologies and global immunization initiatives. Increasing adoption of mRNA therapy platforms is further accelerating innovation and strengthening the segment’s leadership across infectious disease treatment applications worldwide.
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Purchase the Regional Overview for USD 1099
If you choose to purchase the full report at a later stage, the amount already paid will be adjusted, and you will only need to pay the remaining balance.
Purchase the Regional Overview for USD 1099
If you choose to purchase the full report at a later stage, the amount already paid will be adjusted, and you will only need to pay the remaining balance.
Purchase the Regional Overview for USD 1099
If you choose to purchase the full report at a later stage, the amount already paid will be adjusted, and you will only need to pay the remaining balance.
Read more about this report - Request a Free Sample
RNA Therapeutics Market Analysis by Region
North America commanded over 45% of the market share in the historical period, supported by robust research infrastructure and strong regulatory backing. The region benefits from significant investment in biotechnology innovation and advanced clinical pipelines. The growing integration of siRNA technologies in targeted therapies is enhancing treatment precision and reinforcing North America’s leadership in RNA-based therapeutic development globally.
Leading Players in the RNA Therapeutics Market
The key features of the market report comprise patent analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the market are as follows:
Moderna, Inc.
Headquartered in Cambridge, Massachusetts, USA, Moderna, Inc. was founded in 2010. The company is a pioneer in messenger RNA technology and gained global recognition for its COVID-19 vaccine, Spikevax. Moderna continues to expand its portfolio across oncology, rare diseases, and infectious diseases, with strong focus on mRNA therapy, enabling targeted treatments and advancing next-generation genetic medicine platforms globally.
BioNTech SE
BioNTech SE, headquartered in Mainz, Germany, was established in 2008. The company is a leader in RNA-based therapeutics and co-developed the COVID-19 vaccine Comirnaty with Pfizer. BioNTech is advancing a diverse pipeline across oncology and infectious diseases, with growing emphasis on RNA-based vaccine development, supporting innovation in immunotherapy and next-generation vaccine platforms worldwide.
Alnylam Pharmaceuticals, Inc.
Alnylam Pharmaceuticals, Inc., founded in 2002 and headquartered in Cambridge, Massachusetts, is a leader in RNA interference therapeutics. The company focuses on gene silencing technologies to treat genetic and metabolic disorders. Its portfolio includes approved therapies and a strong pipeline leveraging siRNA, enabling targeted gene regulation and advancing precision medicine approaches across multiple rare and chronic disease indications.
Ionis Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc., established in 1989 and headquartered in Carlsbad, California, specializes in RNA-targeted therapeutics. The company develops antisense technologies to treat genetic and neurological conditions. Its portfolio includes approved drugs such as Spinraza, with continued innovation in gene expression modulation. Ionis is advancing therapies using antisense oligonucleotide, strengthening its leadership in RNA-based drug development globally.
Other key players in the market are Arcturus Therapeutics Holdings Inc., CureVac N.V., Sarepta Therapeutics, Inc., Wave Life Sciences Ltd., Sanofi S.A., and Novo Nordisk A/S.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Key Questions Answered in the RNA Therapeutics Market Report
- What was the RNA therapeutics market value in 2025?
- What is the RNA therapeutics market forecast outlook for 2026-2035?
- What major factors aid the demand for RNA therapeutics market?
- How has the market performed so far, and how is it anticipated to perform in the coming years?
- What are the market’s major drivers, opportunities, and restraints?
- What are the major RNA therapeutics market trends?
- Which product is expected to dominate the market segment?
- Which type is expected to dominate the market segment?
- Which indication is expected to dominate the market segment?
- Which end user is expected to dominate the market segment?
- Who are the key players in the RNA therapeutics market?
- What are the current unmet needs and challenges in the market?
- How are partnerships, collaborations, mergers, and acquisitions among the key market players shaping the market dynamics?
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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
Report Summary
Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.
| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Product |
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| Breakup by Type |
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| Breakup by Indication |
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| Breakup by End User |
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| Breakup by Region |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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