The United States bone void fillers market was valued at USD 1.45 Billion in 2025 and is expected to grow at a CAGR of 6.50%, reaching USD 2.72 Billion by 2035. The market is experiencing growth due to rising prevalence of bone fractures and increasing adoption of synthetic bone grafts.
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According to the CDC, neural tube defects like spina bifida affects approximately 1 in 2,875 births in the U.S., impacting around 1,278 babies annually. This is driving the demand for bone void fillers to support bone repair and reconstruction, boosting market growth.
In April 2023, Abyrx received additional FDA clearances for its Montage Settable, resorbable bone putty as a bone void filler and cranial bone cement. This expansion is expected to drive significant growth in the United States bone void fillers market.
The market is expanding rapidly due to increasing orthopedic surgeries, aging demographics, rising adoption of synthetic fillers, antibiotic-eluting technologies, and minimally invasive procedures.
Compound Annual Growth Rate
6.5%
Value in USD Billion
2026-2035
*this image is indicative*
Bone void fillers are biomaterials used to fill gaps or voids in bones caused by trauma, surgery, or disease, promoting bone regeneration and structural support. These fillers can be synthetic or natural and aid in accelerating the healing process. The market was valued at USD 1.45 Billion in 2025, driven by increasing orthopedic procedures, rising incidence of bone-related disorders, and technological advancements in biomaterials. The growing geriatric population and demand for minimally invasive surgeries further contribute to market growth in the region.
Rising Incidence of Primary Malignant Bone Tumors to Fuel the Market Growth in the United States
The increasing incidence of primary malignant bone tumors is emerging as a significant growth driver in the market. These tumors often lead to bone defects that require surgical intervention and subsequent filling, thereby boosting the demand for advanced bone void fillers. In May 2025, Hasan Hosseini et al. referenced data from the SEER database indicating an annual incidence rate of approximately 0.9 per 100,000 individuals. Among these, osteosarcoma accounts for about 35% of cases, followed by chondrosarcoma at 30% and Ewing’s sarcoma at 16%. The rising burden of these conditions has heightened the need for effective reconstructive and regenerative solutions post-tumor resection. This trend is expected to continue driving steady market growth in the coming years.
The market is experiencing several key trends, including an increase in product launches and portfolio expansions, as well as growing adoption of resorbable bone void fillers.
The market report offers a detailed analysis of the market based on the following segments:
Market Breakup by Type
Market Breakup by Form
Market Breakup by End User
Calcium Sulphate and Tri-Calcium Phosphate to Lead the Market Share by Type
Calcium sulphate and tri-calcium phosphate-based products are gaining traction among other segments like demineralized bone matrix, collagen matrix, and others. The market share can be attributed to their biocompatibility, osteoconductive properties, and ability to mimic natural bone mineral content. For instance, in April 2023, Anika Therapeutics received FDA clearance for Tactoset, an injectable bone substitute that combines calcium phosphate with autologous bone marrow aspirate, expanding treatment options and driving significant growth in the United States bone void fillers market.
The key features of the market report comprise patent analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the market are as follows:
Stryker Corporation, established in 1941 and headquartered in Kalamazoo, Michigan, is a leading medical technology company specializing in orthopedics and surgical equipment. In the bone void fillers market, Stryker offers innovative solutions such as Pro-Dense LoVisc, an injectable regenerative graft that enhances bone regeneration through improved injectability and flowability. This product supports predictable, dense bone regrowth and demonstrates the company’s active role in advancing orthopedic care.
Zimmer Biomet Holdings, Inc., headquartered in Warsaw, Indiana, and established in 1927, is a key player in the bone void fillers market. The company offers Calcigen S calcium sulfate bone void filler, a quick-setting, resorbable graft material designed to support bone growth. With features such as easy mixing, moldable flexibility, and intraoperative hardening, Zimmer Biomet reinforces its commitment to advancing biologic solutions in orthopedic care.
Established in 1895, DePuy Synthes, a Johnson & Johnson company, plays a prominent role in the bone void fillers market. Its Fibergraft bioactive bone graft substitute, made from 45S5 bioactive glass, promotes osteoblast activity and bone regeneration. Offered in four formulations, it addresses bony voids and supports customized surgical applications.
Arthrex, Inc. is a global medical device company specializing in orthopedic surgical solutions. It was established in 1981 and is headquartered in Naples, Florida. In the bone void fillers market, Arthrex offers a range of innovative bone grafting options, including various allograft products and advanced synthetic bone void fillers. Its bone graft harvester set, designed for minimally invasive procedures, reflects the company’s commitment to enhancing surgical outcomes through cutting-edge technology.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other key players in the market include Medtronic plc., Biocomposites Ltd., Bonesupport AB, Collagen Matrix, Inc., Orthofix Medical Inc., and NuVasive, Inc.
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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Type |
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| Breakup by Form |
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| Breakup by End User |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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