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The United States diabetes drugs market was valued at USD 14.70 Billion in 2025 and is expected to grow at a CAGR of 4.90%, reaching USD 23.72 Billion by 2035. The market growth is driven by the increasing prevalence of diabetes, advancements in drug delivery systems, and growing adoption of innovative therapies such as GLP-1 receptor agonists and SGLT2 inhibitors. Rising healthcare expenditure, strong R&D activities, and expanding awareness programs further enhance market growth, while the introduction of personalized and combination treatments boosts long-term value.
Base Year
Historical Period
Forecast Period
In July 2025, Lupin received USFDA approvals for its Liraglutide and Glucagon injectable products, expanding access to critical diabetes therapies. Such approvals are expected to accelerate market growth by enhancing treatment availability and affordability.
One of the major market trends includes strategic acquisitions to expand innovative diabetes treatments. For instance, in March 2023, Sanofi acquired Provention Bio, adding TZIELD, the first therapy to delay Stage 3 type 1 diabetes, boosting the market growth.
The market is growing steadily due to rising diabetes prevalence, innovative drug development, and increasing awareness. Key players drive market growth through continuous R&D, advanced therapies, and expanded treatment accessibility.
Compound Annual Growth Rate
4.9%
Value in USD Billion
2026-2035
*this image is indicative*
Diabetes drugs include a wide spectrum of therapeutic agents developed to control blood glucose levels and prevent diabetes-related complications. These medications act through diverse mechanisms, including enhancing insulin secretion, improving insulin sensitivity, and reducing glucose absorption. The diabetes drugs market in United States is expanding due to rising diabetes incidence, sedentary lifestyles, and a growing aging population. Moreover, strong investments in research, favorable reimbursement policies, and advancements in biologics and biosimilars are fueling market growth. The market was valued at USD 14.70 Billion in 2025, highlighting sustained demand and innovation in diabetes management. The increasing focus on patient-centric care, early diagnosis, and the adoption of innovative formulations such as oral glucagon-like peptide-1 (GLP-1) receptor agonists are shaping the therapeutic landscape.
Expanding Access to Affordable Therapies Accelerating the Market Demand
The rising focus on improving patient access to affordable and effective treatment options for type II diabetes is a significant factor driving the growth in the market. Supporting this trend, in December 2024, the U.S. Food and Drug Administration approved the first generic of once daily liraglutide injection, referencing Victoza, developed by Hikma Pharmaceuticals USA Inc. This approval marks a significant step toward reducing treatment costs and addressing ongoing shortages of GLP-1 receptor agonists. Such initiatives are expected to enhance medication accessibility, driving consistent market growth across the nation.
Key trends in the market include the increasing adoption of interchangeable biosimilar insulins and the growing use of generic GLP-1 therapies.
Rising Adoption of Interchangeable Biosimilar Insulins is Likely to Propel the Market in the United States
The increasing adoption of interchangeable biosimilar insulins, enhancing affordability and patient access, is a growing trend shaping the market growth. In July 2025, Biocon Biologics Ltd. received U.S. FDA approval for Kirsty™ (Insulin Aspart-xjhz), the first and only interchangeable rapid-acting biosimilar insulin aspart. This milestone strengthens Biocon’s leadership in biosimilar insulin therapy and expands treatment options for diabetes patients. Such approvals are expected to accelerate innovation, competition, and affordability, significantly boosting the market’s overall growth trajectory.
Growing Adoption of Generic GLP-1 Therapies is Boosting the Market Value
The market is witnessing a significant shift with the rising adoption of generic GLP-1 receptor agonists, improving affordability and accessibility for patients with type 2 diabetes. In June 2024, Teva Pharmaceuticals, Inc. launched the authorized generic of Victoza® (liraglutide injection 1.8mg), marking the first-ever generic GLP-1 product in the U.S. market. This development underscores growing competition and innovation in diabetes management solutions, ultimately enhancing treatment availability and driving the overall growth of the diabetes drugs market in the United States.
Type II Expected to Lead the Market Share by Diabetes Type
The market is segmented by diabetes type into Type I and Type II. Among these, Type II diabetes is projected to lead the market during the forecast period, driven by its significantly higher prevalence and the increasing adoption of advanced therapeutic options such as GLP-1 receptor agonists and SGLT2 inhibitors. The rising incidence among adults, along with growing cases among younger populations, further contributes to market expansion. The Centers for Disease Control and Prevention (CDC) reported that over 38 million Americans have diabetes, with 90% to 95% suffering from Type II diabetes, emphasizing its substantial dominance. Continuous drug innovation and lifestyle awareness programs are anticipated to reinforce the segment’s market leadership in the coming years.
The key features of the market report include clinical trials and pipeline analysis, patent analysis, funding and investment analysis, and strategic initiatives by leading players. The major companies in the market are as follows:
Eli Lilly and Company, a leading American pharmaceutical firm, is advancing its position in the market through the development of its experimental oral GLP-1 drug, orforglipron. In late-stage trials, the pill demonstrated superior blood sugar control and weight reduction in patients with type 2 diabetes compared to AstraZeneca’s Farxiga. Designed to mimic the GLP-1 hormone, orforglipron aims to provide an effective oral alternative to injectable treatments such as Lilly’s Mounjaro and Zepbound. The company plans to submit the drug for regulatory approval in 2026, reinforcing its commitment to innovative diabetes therapies.
AstraZeneca Plc is a leading global biopharmaceutical company headquartered in Cambridge, UK, focused on developing innovative medicines across major therapeutic areas. In June 2024, the company received U.S. FDA approval for its drug Farxiga (dapagliflozin) to treat pediatric patients aged 10 years and older with type-2 diabetes. Based on results from the T2NOW Phase III trial, this approval marks a key advancement in the United States diabetes drugs market, expanding treatment options for younger patients. Farxiga, a first-in-class oral SGLT2 inhibitor, demonstrated significant improvements in glycemic control, reinforcing AstraZeneca’s commitment to advancing therapies in cardiovascular, renal, and metabolic diseases.
Merck & Co., Inc., known as MSD outside the United States and Canada, is a global healthcare company strongly committed to advancing diabetes care. In the United States diabetes drugs market, Merck is recognized for its leading DPP-4 inhibitors, Januvia® (sitagliptin) and Janumet® (sitagliptin and metformin HCl), which help improve glycemic control in adults with type 2 diabetes. The company continues to expand its diabetes portfolio through the development of innovative treatments such as omarigliptin, an investigational once-weekly DPP-4 inhibitor, and MK-1293, an insulin glargine candidate. Additionally, Merck’s collaborations with Pfizer and Samsung Bioepis demonstrate its long-term commitment to providing advanced, effective therapeutic options for diabetes management.
Novartis AG, a global healthcare leader headquartered in Basel, Switzerland, plays a significant role in the market. The company’s landmark five-year VERIFY study demonstrated that early combination therapy with vildagliptin (Galvus®) and metformin provides superior long-term glycemic control compared to standard monotherapy in patients with type 2 diabetes. This Phase IV trial emphasized the durability, safety, and efficacy of the vildagliptin–metformin regimen, reinforcing Novartis’s commitment to optimizing patient management and improving long-term outcomes in type 2 diabetes care.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other key players in the market include Sanofi, Takeda Pharmaceutical Company Limited., Boehringer Ingelheim International GmbH, Novo Nordisk A/S, Dexcom, Inc., and F. Hoffmann La Roche.
The market report offers a detailed analysis of the market based on the following segments:
Market Breakup by Drugs
Market Breakup by Diabetes Type
Market Breakup by Distribution Channel
Market Breakup by End User
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Drugs |
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| Breakup by Diabetes Type |
|
| Breakup by Distribution Channel |
|
| Breakup by End User |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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