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Report Overview

Nonmelanoma skin cancer, primarily comprising basal cell carcinoma and cutaneous squamous cell carcinoma, represents one of the most common malignancies worldwide and a growing public health concern. According to GLOBOCAN 2022 estimates, nonmelanoma skin cancers were the fifth most common cancer globally, with approximately 1,234,533 new cases and around 69,416 deaths reported worldwide in that year. Its prevalence continues to rise, particularly among aging populations and regions with high ultraviolet exposure, contributing to a substantial healthcare burden despite relatively low mortality. The nonmelanoma skin cancer pipeline analysis by Expert Market Research highlights continued innovation across targeted and immunotherapeutic approaches aimed at improving long-term disease control.

  • Major companies involved in the nonmelanoma skin cancer pipeline analysis include AstraZeneca, KaliVir Immunotherapeutics, and others.

  • Leading drugs currently in the pipeline include N17350, AZD6750, and others.

  • The pipeline is driven by the rising incidence of advanced basal and squamous cell carcinomas, increasing adoption of immunotherapies such as cemiplimab, and innovations in targeted and topical therapies. Novel gene-based and polymer-based treatments are accelerating development, expanding therapeutic options for patients unsuitable for conventional surgery or radiotherapy.

Report Coverage

The Nonmelanoma Skin Cancer Pipeline Analysis Report by Expert Market Research gives comprehensive insights into nonmelanoma skin cancer therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for nonmelanoma skin cancer. The nonmelanoma skin cancer report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The nonmelanoma skin cancer pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with nonmelanoma skin cancer treatment guidelines to ensure optimal care practices.

The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to nonmelanoma skin cancer.

Nonmelanoma Skin Cancer Pipeline Analysis by Drug Class

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Nonmelanoma Skin Cancer Pipeline Outlook

Nonmelanoma skin cancer (NMSC), predominantly basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC), is typically managed with surgical excision, radiotherapy. For advanced disease, systemic therapies such as hedgehog inhibitors and immune checkpoint inhibitors are commonly employed. The pipeline continues to prioritize targeted and immunotherapeutic approaches to improve outcomes and reduce recurrence.

Nonmelanoma skin cancer treatment has recently advanced with the October 2025 FDA approval of cemiplimab-rwlc (Libtayo) as an adjuvant treatment for adults with high-risk CSCC following surgery and radiotherapy, aimed at lowering the risk of disease recurrence. Emerging agents in trials seek enhanced efficacy with favorable safety profiles.

Nonmelanoma Skin Cancer Epidemiology

Nonmelanoma skin cancers, primarily basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are among the most frequently diagnosed cancers worldwide. According to GLOBOCAN 2022, there were an estimated 1.23 million new NMSC cases and about 69,000 deaths globally in that year, ranking NMSC fifth in overall cancer incidence. Incidence is highest in high-income regions such as Australasia, North America and Europe, driven by ultraviolet exposure and aging populations, while rates in Asia and Africa remain lower. The burden continues to increase with demographic shifts and enhanced detection.

Nonmelanoma Skin Cancer – Pipeline Therapeutic Assessment

This section of the report covers the analysis of nonmelanoma skin cancer drug candidates based on several segmentations, including:

By Phase

The pipeline assessment report covers 50+ drug analyses based on phase:

  • Late-Stage Products (Phase 3 and Phase 4)
  • Mid-Stage Products (Phase 2)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

By Drug Class

The nonmelanoma skin cancer pipeline analysis report covers 50+ drug analyses based on drug classes:

  • Small Molecules
  • Monoclonal Antibodies
  • Peptides
  • Polymers
  • Gene Therapies

By Route of Administration

The pipeline assessment report covers 50+ drug analyses based on the route of administration:

  • Oral
  • Parenteral
  • Others

Nonmelanoma Skin Cancer Pipeline Assessment Segmentation, By Phases

The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase II covers a major share of the total nonmelanoma skin cancer clinical trials. The phase 1 covers 29%, phase 2 accounts for 43%, and phase 3 covers 24% drugs, providing an in-depth analysis of each.

Nonmelanoma Skin Cancer Pipeline Assessment Segmentation, By Drug Classes

The drug molecule categories covered under the nonmelanoma skin cancer pipeline analysis include monoclonal antibodies, small molecules, peptides, polymers, and gene therapies. The nonmelanoma skin cancer report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for nonmelanoma skin cancer. In December 2024, the FDA approved cosibelimab-ipdl (Unloxcyt) for adults with advanced cutaneous squamous cell carcinoma that is locally advanced or metastatic and not suitable for curative surgery or radiotherapy.

Nonmelanoma Skin Cancer Clinical Trials – Key Players

The EMR report for the nonmelanoma skin cancer pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed nonmelanoma skin cancer therapeutic assessment, analysing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in nonmelanoma skin cancer clinical trials:

  • Phio Pharmaceuticals Inc.
  • Onchilles Pharma Inc
  • AstraZeneca
  • KaliVir Immunotherapeutics
  • Regeneron Pharmaceuticals
  • Stamford Pharmaceuticals, Inc.
  • Sirnaomics
  • AiViva BioPharma, Inc.
  • Feldan Therapeutics
  • Verrica Pharmaceuticals Inc.

Nonmelanoma Skin Cancer – Emerging Drugs Profile

This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for nonmelanoma skin cancer. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of nonmelanoma skin cancer drug candidates.

Drug: N17350

N17350 is an engineered tumor‑directed cytotoxic biologic utilising the ELANE pathway to selectively kill cancer cells while sparing healthy tissue and activating systemic immune responses. It induces immunogenic cell death and shows potent anti‑tumor efficacy in preclinical models of diverse solid tumors, including skin cancers. Onchilles Pharma, a biotechnology company pioneering next‑generation cytotoxic therapies, is advancing N17350 toward first‑in‑human trials, supported by extensive translational data and recent financing to propel clinical development. The study is anticipated to be completed on November 2029.

Drug: AZD6750

AZD6750 is a novel CD8‑guided interleukin‑2 (IL‑2) agent being evaluated for safety, pharmacokinetics and efficacy in advanced or metastatic solid tumors, including cutaneous squamous cell carcinoma (a form of nonmelanoma skin cancer). It may be administered alone or with other anticancer agents to stimulate immune‑mediated tumor control. AstraZeneca, a global biopharmaceutical leader in oncology, is conducting this Phase 1/2 clinical study as part of its broad immuno‑oncology pipeline. The study is expected to be completed by February 2029.

Drug: MQ710

MQ710 is an investigational biological therapeutic being assessed in early‑phase clinical trials as part of combination immuno‑oncology regimens for solid tumors, including basal cell carcinoma and other skin cancers. It functions by leveraging modified viral vectors or transgene expression mechanisms to enhance anti‑tumor immune activity in conjunction with immune checkpoint inhibitors such as pembrolizumab. This trial is sponsored by the Memorial Sloan Kettering Cancer Center and targets a range of solid tumor types where conventional therapies have failed. The study is likely to be completed by May 2028.

*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*

Key Questions Answered in the Nonmelanoma Skin Cancer Pipeline Insight Report

  • Which companies/institutions are leading the nonmelanoma skin cancer drug development?
  • Which company is leading the nonmelanoma skin cancer pipeline development activities?
  • What is the current nonmelanoma skin cancer commercial assessment?
  • What are the opportunities and challenges present in the nonmelanoma skin cancer pipeline landscape?
  • What is the efficacy and safety profile of nonmelanoma skin cancer pipeline drugs?
  • Which company is conducting major trials for nonmelanoma skin cancer drugs?
  • Which companies/institutions are involved in nonmelanoma skin cancer collaborations aimed at providing enhanced therapeutic alternatives for patients?
  • What are the geographies covered for clinical trials in nonmelanoma skin cancer?

Reasons To Buy This Report

The Nonmelanoma Skin Cancer Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for nonmelanoma skin cancer. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into nonmelanoma skin cancer collaborations, regulatory environments, and potential growth opportunities.

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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Scope of the Report

Details

Drug Pipeline by Clinical Trial Phase

  • Late-Stage Products (Phase III and Phase IV)
  • Mid-Stage Products (Phase II)
  • Early-Stage Products (Phase I)
  • Preclinical and Discovery Stage Products

Route of Administration

  • Oral
  • Parenteral
  • Others

Drug Classes

  • Monoclonal Antibodies
  • Small Molecules
  • Peptides
  • Polymers
  • Gene Therapies

Leading Sponsors Covered

  • Phio Pharmaceuticals Inc.
  • Onchilles Pharma Inc
  • AstraZeneca
  • KaliVir Immunotherapeutics
  • Regeneron Pharmaceuticals
  • Stamford Pharmaceuticals, Inc.
  • Sirnaomics
  • AiViva BioPharma, Inc.
  • Feldan Therapeutics
  • Verrica Pharmaceuticals Inc.

Geographies Covered

  • North America
  • Europe
  • Asia Pacific
  • Others

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