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Limb-Girdle Muscular Dystrophy (LGMD) is a rare neuromuscular disorder characterized by progressive weakness in the shoulder and pelvic muscles, significantly affecting mobility and quality of life. The limb-girdle muscular dystrophy (LGMD) epidemiology forecast by Expert Market Research highlights its rarity, aligning with Orphanet (2024) estimates that indicate a global prevalence of 1 to 9 cases per 100,000 individuals. This underscores the urgent need for enhanced diagnostic approaches and therapeutic advancements to support affected individuals worldwide.
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Expert Market Research's “Limb-Girdle Muscular Dystrophy (LGMD) Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of limb-girdle muscular dystrophy (LGMD). It projects the future incidence and prevalence rates of limb-girdle muscular dystrophy (LGMD) cases across various populations. The study covers age, gender, and type as major determinants of the limb-girdle muscular dystrophy (LGMD) population. The report highlights patterns in the prevalence of limb-girdle muscular dystrophy (LGMD) over time and projects future trends based on multiple variables.
The report provides a comprehensive overview of the disease, as well as historical and projected data on Limb-Girdle Muscular Dystrophy (LGMD) epidemiology in the 8 major markets.
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Limb-girdle muscular dystrophy (LGMD) comprises a group of genetically inherited disorders characterized by progressive weakness of the hip and shoulder muscles. It results from mutations in over 30 genes affecting sarcolemmal stability, repair, or metabolism. Symptoms typically appear in late childhood or adulthood, leading to mobility challenges and, in some cases, cardiopulmonary involvement. The disease affects both sexes equally and progresses variably depending on subtype. Diagnosis is established through genetic testing, electromyography, and muscle biopsy confirming dystrophic changes.
The limb-girdle muscular dystrophy (LGMD) epidemiology division offers information on the patient pool from history to the present, as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the limb-girdle muscular dystrophy (LGMD) epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for limb-girdle muscular dystrophy (LGMD) and their trends. The limb-girdle muscular dystrophy (LGMD) detailed epidemiology segmentation is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

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The limb-girdle muscular dystrophy (LGMD) epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.
In the United States, limb-girdle muscular dystrophy (LGMD) remains a rare neuromuscular disorder, affecting an estimated 2 per 100,000 individuals according to the Cleveland Clinic. The Muscular Dystrophy Association (MDA) reports that approximately 5,000 Americans currently live with the condition. The prevalence varies by genetic subtype, with calpainopathy (CAPN3) and dysferlinopathy (DYSF) being among the most frequently identified in U.S. cohorts. Increased access to genetic testing has improved diagnosis, revealing broader subtype diversity and aiding in targeted therapeutic research nationwide.
Management of limb-girdle muscular dystrophy is primarily supportive, focusing on physiotherapy, orthopedic interventions, and respiratory monitoring. Corticosteroids are sometimes used for select subtypes to slow progression. Emerging gene therapies and exon-skipping technologies target molecular defects, particularly in CAPN3- and DYSF-related LGMD. Recent advances include adeno-associated virus (AAV)-based gene replacement therapies showing promise in clinical trials. Assistive mobility devices, cardiac care, and multidisciplinary rehabilitation improve quality of life and functional outcomes. No curative therapy exists, but research in precision medicine is accelerating therapeutic innovation.
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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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Base Year |
2025 |
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Historical Period |
2019-2025 |
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Forecast Period |
2026-2035 |
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