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Report Overview

Peripheral neuropathic pain represents a significant global burden, with rising prevalence influenced by aging populations and gender disparities. Understanding these epidemiological patterns supports improved assessment and targeted intervention strategies worldwide. The peripheral neuropathic pain (PNP) epidemiology forecast by Expert Market Research reveals that diabetes mellitus is the single most significant contributor to PNP worldwide. Approximately 20–30% of all people with diabetes develop painful diabetic peripheral neuropathy (DPN), and because global diabetes prevalence exceeds 530 million individuals, this translates to well over 100 million people living with PNP from diabetes alone.

2025

Base Year

2019-2025

Historical Period

2026-2035

Forecast Period

Peripheral Neuropathic Pain (PNP) – Number of Cases by Year

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Peripheral Neuropathic Pain (PNP) Epidemiology Forecast Report Coverage

Expert Market Research's “Peripheral Neuropathic Pain (PNP) Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of peripheral neuropathic pain (PNP). It projects the future incidence and prevalence rates of peripheral neuropathic pain (PNP) cases across various populations. The study covers age, gender, and type as major determinants of the peripheral neuropathic pain (PNP) population. The report highlights patterns in the prevalence of peripheral neuropathic pain (PNP) over time and projects future trends based on multiple variables.

The report provides a comprehensive overview of the disease, as well as historical and projected data on peripheral neuropathic pain (PNP) epidemiology in the 8 major markets.

Regions Covered

  • The United States
  • Germany
  • France
  • Italy
  • Spain
  • The United Kingdom
  • Japan
  • India

Peripheral Neuropathic Pain (PNP) Understanding: Disease Overview

Peripheral neuropathic pain arises from injury, disease, or dysfunction of peripheral nerves. It may develop due to diabetes, postherpetic neuralgia, chemotherapy, HIV infection, alcoholism, trauma, or idiopathic causes. Patients experience burning pain, shooting sensations, numbness, or heightened sensitivity that persists beyond normal healing. The condition involves aberrant nerve signaling, altered ion channel function, and central sensitization. Prevalence increases with age and chronic metabolic diseases. PNP significantly reduces quality of life, impairing sleep, mobility, and daily functioning. Early identification and etiology-specific management are essential for long-term control.

Peripheral Neuropathic Pain (PNP) Epidemiology Perspective

The peripheral neuropathic pain (PNP) epidemiology division offers information on the patient pool from history to the present, as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the peripheral neuropathic pain (PNP) epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for peripheral neuropathic pain (PNP) and its trends. The peripheral neuropathic pain (PNP) detailed epidemiology segmentation is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

  • Globally, painful diabetic peripheral neuropathy (PDPN) affects nearly 47% of individuals living with diabetic peripheral neuropathy, indicating a substantial symptomatic burden within this high-risk population.
  • Age contributes meaningfully to PDPN epidemiology, with risk increasing gradually as individuals grow older, reflecting the progressive nature of neuropathic complications in diabetes.
  • PNP prevalence increases with age, peaking in older adults (notably ages ~60-70), where population estimates and screening studies report the highest rates.
  • Female sex is a consistent risk factor for painful diabetic neuropathy and many PNP syndromes.
  • Chemotherapy-induced peripheral neuropathy (CIPN) contributes significantly to PNP prevalence in cancer survivors. Up to 40–60% of patients receiving platinum agents, taxanes, or vinca alkaloids develop neuropathy, and approximately 20–30% of these individuals report chronic neuropathic pain that persists after treatment.
  • PNP prevalence increases steadily with age, multimorbidity, and reduced socioeconomic status. Women consistently report neuropathic pain more frequently than men, with sex-specific prevalence differences of 1–2 percentage points in many studies.

Peripheral Neuropathic Pain (PNP) – Number of Cases by Country

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Country-wise Peripheral Neuropathic Pain (PNP) Epidemiology Segment

The peripheral neuropathic pain (PNP) epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.

The United Kingdom presents a meaningful perspective on the burden of peripheral neuropathic pain, reflecting the broader global challenges in assessing chronic sensory disorders. Epidemiological observations indicate that neuropathic pain affects approximately 9.2% of UK adults experiencing chronic pain lasting three months or longer, underscoring a substantial population impact. This burden is particularly influenced by age-related increases and a higher prevalence among women, highlighting important demographic patterns. Overall, the UK landscape emphasizes the need for continued surveillance to better guide future clinical and research priorities.

Peripheral Neuropathic Pain (PNP): Treatment Overview

Management of peripheral neuropathic pain aims to reduce abnormal nerve activity and improve functional outcomes. First-line treatments include gabapentinoids, serotonin–norepinephrine reuptake inhibitors, and tricyclic antidepressants. Topical lidocaine or capsaicin is used for localized pain. Second-line options include opioids, though restricted due to risks. Etiology-focused care, such as glucose control or chemotherapy dose adjustments, improves response. Interventional approaches, nerve blocks, spinal cord stimulation, or TENS, are considered for refractory cases. Multidisciplinary strategies integrating physical therapy and psychological support provide additional relief and help prevent chronic disability.

Key Questions Answered

  • What are the key findings of peripheral neuropathic pain (PNP) epidemiology in the 8 major markets?
  • What will be the total number of patients with peripheral neuropathic pain (PNP) across the 8 major markets during the forecast period?
  • What was the country-wise peripheral neuropathic pain (PNP) epidemiology scenario in the 8 major markets in the historical period?
  • Which country will have the highest number of cases of peripheral neuropathic pain (PNP) during the forecast period of 2026-2035?
  • Which key factors would influence the shift in the patient population of peripheral neuropathic pain (PNP) during the forecast period of 2026-2035?
  • What are the currently available treatments for peripheral neuropathic pain (PNP)?
  • What are the disease risks, signs, symptoms, and unmet needs of peripheral neuropathic pain (PNP)?

Scope of the Peripheral Neuropathic Pain (PNP) Epidemiology Report

  • The report covers a detailed analysis of signs and symptoms, causes, risk factors, pathophysiology, diagnosis, treatment options, and classification/types of peripheral neuropathic pain (PNP) based on several factors.
  • Peripheral Neuropathic Pain (PNP) Epidemiology Forecast Report covers data for the eight major markets (the US, France, Germany, Italy, Spain, the UK, Japan, and India).
  • The peripheral neuropathic pain (PNP) report helps to identify the patient population, and the unmet needs are highlighted along with an assessment of the disease's risk and burden.

Related Reports

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Diabetic Neuropathic Pain Market

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Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

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Details 

Base Year 

2025

Historical Period

2019-2025

Forecast Period

2026-2035

Epidemiology Statistics Provided

  • Diagnosed Prevalent Cases
  • Type-Specific Cases
  • Gender-Specific Cases
  • Age-Specific Cases

Segmentation Provided

  • Epidemiology by Age Group
  • Epidemiology by Gender
  • Epidemiology by Type of Disease
  • Epidemiology by Region

Geographies Covered 

  • United States
  • Germany
  • Italy
  • France
  • Spain
  • United Kingdom
  • Japan
  • India

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