Top 8 Companies in the Global Orthopedic Biomaterials Market in 2025

The global orthopedic biomaterials market was valued at USD 22.75 Billion in 2024. The market is expected to grow at a CAGR of 7.50% during the forecast period of 2025-2034, with the values likely to reach USD 46.89 Billion by 2034. The market growth is driven by the increasing prevalence of orthopedic and musculoskeletal diseases across the globe.

Orthopedic biomaterials assist in mending bones and joints by replicating bone properties and enhancing the reduction of unfavorable reactions. Joint replacements, fracture repair, and spinal surgeries have a substantial impact on patient outcomes and implant longevity. Surgeons utilize these materials to improve tissue integration, provide mechanical assistance, and reduce difficulties during various procedures.

The market for orthopedic biomaterials is expanding because of the increased prevalence of orthopedic illnesses and musculoskeletal problems such as arthritis and fractures. Technological advancements such as 3D printing and nanotechnology, together with increased investment, are driving up global market demand. Government and business funding are supporting research into new materials such as biodegradable polymers and bioactive ceramics, leading to market expansion and the development of personalized and long-lasting biomaterials.

In July  2024, 4D Medicine, a United Kingdom-based biotech firm, received EUR 3.4 million in funding for orthopedic biomaterial technology, allowing for the completion of pre-clinical testing and the pursuit of FDA approval. Further, Matexcel expanded its biomedical hydroxyapatite product line in September  2024, with ongoing research and development initiatives focused on increasing market value.

Let’s explore the profile of top companies leading the global orthopedic biomaterials market in 2025.

1. Evonik industries AG

Evonik Industries AG, a company specializing in chemicals based in Germany, provides a range of products like surfactants, polymers, resins, and additives. Their RESOMER ® bioresorbable and vestakeep® PEEK polymers are utilized to improve orthopedic results in both temporary and permanent implant uses.

2. Stryker Corp

Michigan-based Stryker Corporation is a global medical technology company that focuses on orthopedic, medical, surgical, neurotechnology, and spine products. They provide a varied range of products such as bone fixation systems, biomaterials , implants, needles, and custom implants.

3. Depuy Synthes Inc.

DePuy Synthes Inc., a subsidiary of Johnson & Johnson, focuses on orthopedic offerings including trauma, joint reconstruction, spine, and sports medicine. Their offerings consist of the Attune revision knee system, SMARTSET ™, and DePuy CMW™ bone cement, providing primary and revision knee procedure options to surgeons. The company’s range of bone cement, which consists of medium and high viscosity options, plain or with gentamicin, is carefully crafted to fulfill the requirements of modern surgeons.

4. Zimmer Biomet

Zimmer Biomet Holdings, Inc., established in 1927, is a company that focuses on musculoskeletal healthcare and produces medical devices. They provide a range of orthopedic, biologics, sports medicine, extremities, and trauma products, along with digital and robotic technologies. Zimmer Biomet is famous for its use of trabecular  metal® technology, which is created from tantalum and mimics the properties of bone, offering surgical products for orthopedic procedures.

5. Invibo Ltd

Invibio is a reliable ally for medical device producers, focusing on biomaterial solutions for spine, orthopedic, arthroscopy, and cardiovascular medicine. Services provided include production, experimentation, ensuring quality, and advice on biomaterials like PEEK  for spinal fusion & orthopedic devices.

6. Exactech, Inc.

Exactech Inc. is a medical device company specializing in orthopedic implants and associated tools. The company offers hip, shoulder, knee, and extremity implants, along with ExactechGPS  systems. They provide offerings for ambulatory surgery centers, infections, and biological services. The research project investigates the application of innovative biomaterials in shoulder replacement surgery, emphasizing the advantages of contemporary materials such as plasma coatings and 3D-printed parts in enhancing patient results.

7. Matexcel

Matexcel, a leading provider in the field of materials science, supplies polymers, nanoparticles, metals, and ceramics to clients worldwide. In September  2024, they expanded their hydroxyapatite product range to include different sizes and grades for research, medical, and food applications. This mineral is crucial for good health and is frequently utilized in biomedical applications.

8. Heraeus Holding Inc.

Heraeus Holding GmbH is involved in the manufacturing of precious metals, materials, technologies, sensors, medical products, and photovoltaics. The company focuses on bone cements and biomaterials, specializing in the areas of orthopedics and surgery.