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Bupropion Prices, Demand and Supply Overview
Bupropion prices in Germany, the highest-cost reporting region, rose 8.0% in H1 2026, climbing from USD 68.6/KG in Q1 to USD 74.1/KG by Q2 as spring antidepressant and smoking cessation treatment procurement and firmer aminoketone synthesis feedstock costs drove consistent buying following the brief Q1 2026 pricing moderation. Globally, the average rose from USD 47.99/KG in Q1 to USD 51.83/KG in Q2, an 8.0% gain. For H2 2026, a global average of USD 52.20-57.80/KG is expected, with continued firming on Middle East supply disruptions and growing antidepressant and nicotine addiction treatment sector demand globally.
Bupropion is an aminoketone antidepressant and nicotinic acetylcholine receptor antagonist produced by multi-step synthesis from 3-chloropropiophenone through alpha-bromination and condensation with tert-butylamine under controlled conditions to yield the 3-chloro-N-tert-butyl-beta-ketopropylamine hydrochloride active pharmaceutical ingredient. The compound exerts its antidepressant effects through selective inhibition of neuronal norepinephrine and dopamine reuptake transporters without clinically significant serotonin reuptake inhibition, producing an activating and pro-dopaminergic profile distinct from SSRI and SNRI antidepressants. The largest pull comes from major depressive disorder and seasonal affective disorder treatment, where its activating profile supports prescribing in patients with energy deficit, cognitive slowing, and hypersomnia depression features, and in those who have experienced sexual dysfunction with other antidepressant classes. Sustained-release formulations for smoking cessation, where dopamine reinforcement pathway modulation reduces nicotine craving and withdrawal intensity, add a significant independent demand segment growing with global smoking cessation programme expansion. ADHD management in adults and weight management combination formulations add further demand. Aminoketone synthesis feedstock costs, antidepressant and smoking cessation prescription volumes, and regional API production capacity all feed into the price.
Bupropion Price Forecast for 2026
The balance of supply and demand for bupropion through H2 2026 leans moderately firm. Aminoketone synthesis feedstock costs firmed from Middle East supply disruptions. Antidepressant prescribing volumes, smoking cessation programme procurement, and growing mental health treatment access are expanding with increasing awareness and guideline adoption globally.
The main upside risk is synthesis feedstock cost increases alongside accelerating smoking cessation programme and antidepressant access programme procurement. The main downside risk is Chinese and Indian API surplus maintaining competitive price pressure below forecast.
| Region | Price Forecast (USD/KG) | Key Driver |
| Global Average | 52.20 - 57.80 | Synthesis cost firming and antidepressant/cessation demand support |
| United States | 55.90 - 61.50 | Steady antidepressant and smoking cessation demand holds firm |
| China | 39.10 - 44.70 | Large API capacity keeps it the most affordable |
| Germany | 74.70 - 80.30 | High synthesis and energy costs keep it the most expensive |
| India | 53.40 - 59.00 | Growing antidepressant and export demand holds a firm middle |
For the Quarter Ending June 2026
Bupropion Prices Q2 2026:
- United States: USD 60.0/KG
- China: USD 42.0/KG
- Germany: USD 74.1/KG
- India: USD 57.5/KG
Bupropion Prices in the United States
US Bupropion prices averaged USD 60.0/KG in Q2 2026, up 7.9% from USD 55.6/KG in Q1 2026. Firmer synthesis feedstock costs and spring antidepressant and smoking cessation treatment procurement drove consistent buying following the Q1 moderation.
Why did the price of Bupropion change in Q2 2026 in the United States?
Firmer aminoketone synthesis feedstock costs raised the API production floor. Major depressive disorder, seasonal affective disorder, and smoking cessation procurement lifted buying. ADHD management and weight management combination formulation demand provided additional support near USD 60.0/KG.
Bupropion Prices in China
Chinese Bupropion prices averaged USD 42.0/KG in Q2 2026, up 8.0% from USD 38.9/KG in Q1 2026, the lowest among the tracked markets. Spring antidepressant and smoking cessation export and domestic procurement lifted buying. Firmer domestic synthesis costs raised the production floor despite domestic API capacity.
Why did the price of Bupropion change in Q2 2026 in China?
Spring antidepressant and smoking cessation export and domestic procurement lifted buying. Firmer domestic synthesis feedstock costs raised the production floor. Domestic API capacity kept China the most affordable source.
Bupropion Prices in Germany
German Bupropion prices averaged USD 74.1/KG in Q2 2026, up 8.0% from USD 68.6/KG in Q1 2026, the highest among the tracked markets. Higher synthesis feedstock and energy costs elevated European API production economics. Consistent antidepressant, smoking cessation, and seasonal affective disorder demand maintained steady buying.
Why did the price of Bupropion change in Q2 2026 in Germany?
Higher aminoketone synthesis feedstock and energy costs elevated European API production economics. Middle East supply disruptions added cost premiums to synthesis substrate chains. Consistent antidepressant and smoking cessation programme procurement maintained buying near USD 74.1/KG.
Bupropion Prices in India
Indian Bupropion prices averaged USD 57.5/KG in Q2 2026, up 8.1% from USD 53.2/KG in Q1 2026. Growing antidepressant and smoking cessation export and domestic demand supported buying. Firmer synthesis import costs raised the production floor.
Why did the price of Bupropion change in Q2 2026 in India?
Growing antidepressant and smoking cessation export and domestic procurement lifted buying. Firmer aminoketone synthesis import costs raised the production floor. Mental health access programme export demand provided additional buying support near USD 57.5/KG.
For the Quarter Ending March 2026
Bupropion Prices Q1 2026:
- United States: USD 55.6/KG
- China: USD 38.9/KG
- Germany: USD 68.6/KG
- India: USD 53.2/KG
Bupropion Prices in the United States
US Bupropion prices averaged USD 55.6/KG in Q1 2026, easing about 1.0% from Q4 2025. Post-quarter antidepressant and smoking cessation procurement moderation and soft synthesis costs eased the market near USD 55.6/KG.
Why did the price of Bupropion change in Q1 2026 in the United States?
Post-quarter antidepressant and smoking cessation procurement moderation reduced buying urgency. Soft synthesis feedstock costs eased the production floor. The market eased to USD 55.6/KG before the Q2 spring procurement surge.
Bupropion Prices in China
Chinese prices averaged USD 38.9/KG in Q1 2026, easing about 0.8% from Q4 2025. Post-Lunar New Year procurement moderation and soft synthesis costs held the market near USD 38.9/KG.
Why did the price of Bupropion change in Q1 2026 in China?
Post-Lunar New Year antidepressant export and domestic procurement moderation reduced urgency. Soft domestic synthesis costs eased the production floor. The market eased to USD 38.9/KG before the Q2 surge.
Bupropion Prices in Germany
German prices averaged USD 68.6/KG in Q1 2026, easing about 1.0% from Q4 2025. Post-quarter antidepressant and smoking cessation procurement moderation and soft synthesis costs eased the European market near USD 68.6/KG.
Why did the price of Bupropion change in Q1 2026 in Germany?
Post-quarter antidepressant and smoking cessation procurement moderation reduced urgency. Soft synthesis feedstock and energy costs eased the production floor. The market eased to USD 68.6/KG before the Q2 spring procurement surge.
Bupropion Prices in India
Indian prices averaged USD 53.2/KG in Q1 2026, easing about 0.9% from Q4 2025. Post-holiday procurement moderation and soft synthesis import costs held the market near USD 53.2/KG.
Why did the price of Bupropion change in Q1 2026 in India?
Post-holiday antidepressant and smoking cessation procurement moderation reduced urgency. Soft synthesis import costs eased the production floor. The market eased to USD 53.2/KG before the Q2 spring surge.
Quarterly Bupropion Price Trends
Global Bupropion prices followed an alternating pattern, dipping in Q3 2025 and Q1 2026 on seasonal procurement moderation before recovering in Q4 2025 and surging in Q2 2026. The average eased from USD 48.0/KG in Q2 2025 to USD 47.52/KG in Q3, recovered to USD 48.47/KG in Q4, eased to USD 47.99/KG in Q1 2026, then surged to USD 51.83/KG in Q2 2026, a net gain of about 8.0% over the window. Aminoketone synthesis feedstock cycles and antidepressant and smoking cessation procurement seasonality drove the alternating pattern.
| Quarter | Price (USD/KG) | QoQ Change | Direction |
| Q2 2026 | 51.83 | +8.0% | ↑ Rising |
| Q1 2026 | 47.99 | -1.0% | ↓ Falling |
| Q4 2025 | 48.47 | +2.0% | ↑ Rising |
| Q3 2025 | 47.52 | -1.0% | ↓ Falling |
| Q2 2025 | 48.0 | - | - Stable |
| Q3 2026 | In Progress | - | - In Progress |
What was Bupropion Price in 2025?
Bupropion prices firmed modestly through 2025 on consistent antidepressant and smoking cessation demand. The global average opened near USD 47.5/KG in Q1 2025 and closed at USD 48.47/KG in Q4, a full-year gain of about 2.0%. Synthesis feedstock cost dynamics and antidepressant and smoking cessation procurement seasonality drove the quarterly oscillation throughout the year.
Bupropion Prices in the United States in 2025
US prices firmed from about USD 55.5/KG in Q1 2025 to USD 56.2/KG by Q4, a gain of 1.3%. Consistent antidepressant and smoking cessation demand maintained the modest upward trend.
Bupropion Prices in China in 2025
Chinese prices firmed from roughly USD 38.5/KG in Q1 2025 to USD 39.3/KG by Q4, a gain of 2.1%. Growing export antidepressant and smoking cessation demand drove the firming through the year.
Bupropion Prices in Germany in 2025
German prices firmed from about USD 68.2/KG in Q1 2025 to USD 69.3/KG by Q4, a gain of 1.6%. Consistent antidepressant, smoking cessation, and seasonal affective disorder demand and firm synthesis costs supported the market throughout the year.
Bupropion Prices in India in 2025
Indian prices firmed from roughly USD 52.8/KG in Q1 2025 to USD 53.7/KG by Q4, a gain of 1.7%. Growing antidepressant and export demand drove modest firming through the year.
How We Can Help
Expert Market Research: Your Source for Real-Time Bupropion Price Intelligence
Expert Market Research tracks Bupropion prices continuously across every major producing and consuming region. The team traces causation through aminoketone synthesis feedstock economics, antidepressant and smoking cessation procurement cycles, and regional API production capacity. Contact Expert Market Research today for Bupropion pricing data, bespoke market analysis, and strategic procurement advisory.
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Key Questions Answered in the Report
Major depressive disorder and seasonal affective disorder treatment as an NDRI antidepressant with activating properties takes the largest share. Sustained-release formulations for smoking cessation via dopamine reinforcement pathway modulation add a significant independent demand segment. ADHD management in adults and weight management combination formulations also consume significant volumes globally.
The Q2 2026 average was USD 60.0/KG in the United States, USD 42.0/KG in China, USD 74.1/KG in Germany, and USD 57.5/KG in India. Germany remains the highest-priced market.
The global average rose from USD 47.99/KG in Q1 to about USD 51.83/KG in Q2, a gain of around 8.0%. Spring antidepressant and smoking cessation procurement and firmer synthesis feedstock costs drove the H1 2026 surge.
Antidepressant and smoking cessation treatment procurement cycles create alternating quarterly buying patterns. Post-treatment cycle procurement moderation in Q1 and Q3 creates dips while spring and year-end procurement surges in Q2 and Q4 drive upticks.
The global average is expected in the USD 52.20 to 57.80/KG range for H2 2026, with continued firming as synthesis feedstock costs stay elevated and antidepressant and smoking cessation treatment demand grows globally.
Germany sits highest on synthesis and energy costs, the United States and India hold a firm middle on antidepressant and cessation demand, and China prices lowest on domestic API capacity.
This report is updated monthly. For real-time pricing intelligence, contact the Expert Market Research team directly.
Prices respond mainly to aminoketone synthesis feedstock costs, antidepressant and smoking cessation prescription volume cycles, and mental health treatment access expansion. Synthesis precursor prices and smoking cessation programme funding are key signals.
China and India hold the largest bupropion API synthesis capacity. Any synthesis feedstock cost shift ripples across markets within one to two quarters.
Buyers can use quarterly trends and forecasts to time antidepressant and smoking cessation formulation contracts around synthesis cost cycles, build cover when feedstock signals tighten, and monitor mental health prescription volume data as the primary demand signal.
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