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Clofazimine Prices, Demand and Supply Overview
Clofazimine prices in Germany, the highest-cost reporting region, rose 7.0% in H1 2026, climbing from USD 110.4/KG in Q1 to USD 118.1/KG by Q2 as recovering leprosy multidrug therapy, MDR-TB treatment regimen, and atypical mycobacterial infection procurement and firmer riminophenazine synthesis intermediate costs reversed the H2 2025 API market softening. Globally, the average rose from USD 77.91/KG in Q1 to USD 83.36/KG in Q2, a 7.0% gain. For H2 2026, a global average of USD 84.20-92.80/KG is expected, with continued firming on Middle East supply disruptions and growing WHO leprosy MDT and MDR-TB treatment sector demand globally.
Clofazimine is a riminophenazine antiinfective produced by condensation synthesis of 2-hydroxy-3-phenazinecarbonitrile with 4-chloroaniline and isopropylamine under controlled conditions to yield the 3-(p-chloroanilino)-10-(isopropyl)-2,10-dihydro-3H-phenothiazin-2-ylideneamine active structure, a substituted iminophenazine dye derivative with deep red-brown colour and lipophilic properties. The compound exerts its antimycobacterial activity through multiple mechanisms including binding to guanine bases in mycobacterial DNA, generation of reactive oxygen species through electron transport chain disruption, and inhibition of potassium ion transport, producing bactericidal and bacteriostatic effects against slowly replicating mycobacteria including Mycobacterium leprae, Mycobacterium tuberculosis complex, and non-tuberculous mycobacterial species. The largest pull comes from WHO multidrug therapy programmes for leprosy elimination, where clofazimine is a mandatory component of the standard multibacillary and paucibacillary treatment regimens procured through the WHO drug donation programme and national leprosy elimination programmes. MDR-TB and extensively drug-resistant TB treatment regimens endorsed by WHO guidance add a significant and rapidly growing demand segment. Non-tuberculous mycobacterial infection treatment in immunocompromised patients adds further volume. Synthesis intermediate costs, WHO leprosy and MDR-TB programme procurement, and regional API capacity all feed into the price.
Clofazimine Price Forecast for 2026
The balance of supply and demand for clofazimine through H2 2026 leans moderately firm. Riminophenazine synthesis intermediate costs firmed from Middle East supply disruptions. WHO MDR-TB treatment guideline adoption, global leprosy elimination programme procurement, and growing NTM infection management are expanding the demand base significantly.
The main upside risk is synthesis intermediate cost increases alongside accelerating MDR-TB programme scale-up procurement. The main downside risk is continued Chinese and Indian API surplus and competitive pricing maintaining pressure below forecast.
| Region | Price Forecast (USD/KG) | Key Driver |
| Global Average | 84.20 - 92.80 | Synthesis cost firming and leprosy MDT/MDR-TB demand support |
| United States | 90.30 - 98.90 | Steady MDR-TB and NTM infection demand holds firm |
| China | 63.30 - 71.90 | Domestic API capacity keeps it the most affordable |
| Germany | 119.20 - 127.80 | High synthesis and energy costs keep it the most expensive |
| India | 86.20 - 94.80 | Growing leprosy MDT and MDR-TB export demand holds a firm middle |
For the Quarter Ending June 2026
Clofazimine Prices Q2 2026:
- United States: USD 95.9/KG
- China: USD 66.6/KG
- Germany: USD 118.1/KG
- India: USD 90.2/KG
Clofazimine Prices in the United States
US Clofazimine prices averaged USD 95.9/KG in Q2 2026, up 7.0% from USD 89.6/KG in Q1 2026. Firmer synthesis intermediate costs and recovering MDR-TB treatment regimen and leprosy MDT procurement drove consistent buying through the quarter.
Why did the price of Clofazimine change in Q2 2026 in the United States?
Firmer riminophenazine synthesis intermediate costs raised the API production floor. MDR-TB treatment regimen, WHO leprosy MDT, and NTM infection procurement lifted buying. Immunocompromised patient atypical mycobacterial treatment demand provided additional support near USD 95.9/KG.
Clofazimine Prices in China
Chinese Clofazimine prices averaged USD 66.6/KG in Q2 2026, up 7.1% from USD 62.2/KG in Q1 2026, the lowest among the tracked markets. Spring MDR-TB and leprosy MDT export and domestic procurement lifted buying. Firmer domestic synthesis costs raised the floor despite domestic API capacity.
Why did the price of Clofazimine change in Q2 2026 in China?
Spring MDR-TB and leprosy MDT export and domestic procurement lifted buying. Firmer domestic riminophenazine synthesis intermediate costs raised the production floor. Domestic API capacity kept China the most affordable source.
Clofazimine Prices in Germany
German Clofazimine prices averaged USD 118.1/KG in Q2 2026, up 7.0% from USD 110.4/KG in Q1 2026, the highest among the tracked markets. Higher synthesis intermediate and energy costs elevated European API production economics. Recovering MDR-TB treatment, leprosy MDT, and NTM infection demand maintained consistent buying.
Why did the price of Clofazimine change in Q2 2026 in Germany?
Higher riminophenazine synthesis intermediate and energy costs elevated European API production economics. Middle East supply disruptions added cost premiums to phenazine synthesis substrate chains. Recovering MDR-TB, leprosy MDT, and NTM infection procurement maintained buying near USD 118.1/KG.
Clofazimine Prices in India
Indian Clofazimine prices averaged USD 90.2/KG in Q2 2026, up 7.0% from USD 84.3/KG in Q1 2026. Growing leprosy MDT, MDR-TB treatment, and export demand supported buying. Firmer synthesis import costs raised the production floor through the quarter.
Why did the price of Clofazimine change in Q2 2026 in India?
Growing WHO leprosy MDT and MDR-TB treatment export and domestic procurement lifted buying. Firmer riminophenazine synthesis import costs raised the production floor. NTM infection treatment export demand provided additional buying support near USD 90.2/KG.
For the Quarter Ending March 2026
Clofazimine Prices Q1 2026:
- United States: USD 89.6/KG
- China: USD 62.2/KG
- Germany: USD 110.4/KG
- India: USD 84.3/KG
Clofazimine Prices in the United States
US Clofazimine prices averaged USD 89.6/KG in Q1 2026, recovering about 4.0% from the Q4 2025 softening trough. Recovering MDR-TB and leprosy MDT demand and firming synthesis costs held the market near USD 89.6/KG.
Why did the price of Clofazimine change in Q1 2026 in the United States?
Recovering MDR-TB treatment regimen and leprosy MDT procurement maintained buying. Firming riminophenazine synthesis intermediate costs raised the production floor. The market recovered to USD 89.6/KG from the H2 2025 API softening trough.
Clofazimine Prices in China
Chinese prices averaged USD 62.2/KG in Q1 2026, recovering about 4.0% from Q4 2025. Post-Lunar New Year MDR-TB and leprosy MDT restocking and firming synthesis costs held the market near USD 62.2/KG.
Why did the price of Clofazimine change in Q1 2026 in China?
Post-Lunar New Year MDR-TB and leprosy MDT restocking lifted buying. Firming domestic synthesis intermediate costs raised the production floor. The market recovered to USD 62.2/KG from the H2 2025 trough.
Clofazimine Prices in Germany
German prices averaged USD 110.4/KG in Q1 2026, recovering about 4.0% from Q4 2025. Recovering MDR-TB and leprosy MDT demand and firming synthesis and energy costs held the market near USD 110.4/KG.
Why did the price of Clofazimine change in Q1 2026 in Germany?
Recovering MDR-TB and leprosy MDT procurement maintained buying. Firming synthesis intermediate and energy costs held the production floor. The market recovered to USD 110.4/KG from the H2 2025 trough.
Clofazimine Prices in India
Indian prices averaged USD 84.3/KG in Q1 2026, recovering about 4.0% from Q4 2025. Growing leprosy MDT and MDR-TB demand and firming synthesis import costs held the market near USD 84.3/KG.
Why did the price of Clofazimine change in Q1 2026 in India?
Growing WHO leprosy MDT and MDR-TB treatment export and domestic procurement maintained buying. Firming synthesis import costs raised the production floor. The market recovered to USD 84.3/KG from the H2 2025 API softening trough.
Quarterly Clofazimine Price Trends
Global Clofazimine prices declined through H2 2025 on API synthesis cost softening before recovering firmly through Q1 and Q2 2026. The average fell from USD 78.0/KG in Q2 2025 to USD 76.44/KG in Q3 and USD 74.91/KG in Q4, then recovered to USD 77.91/KG in Q1 2026 and USD 83.36/KG in Q2 2026, a net gain of about 6.9% over the window. Riminophenazine synthesis intermediate cost cycles and WHO leprosy MDT and MDR-TB programme procurement drove the H2 2025 softening and H1 2026 recovery.
| Quarter | Price (USD/KG) | QoQ Change | Direction |
| Q2 2026 | 83.36 | +7.0% | ↑ Rising |
| Q1 2026 | 77.91 | +4.0% | ↑ Rising |
| Q4 2025 | 74.91 | -2.0% | ↓ Falling |
| Q3 2025 | 76.44 | -2.0% | ↓ Falling |
| Q2 2025 | 78.0 | - | - Stable |
| Q3 2026 | In Progress | - | - In Progress |
What was Clofazimine Price in 2025?
Clofazimine prices declined through 2025 as API synthesis cost softening and moderated WHO programme procurement weighed on the market. The global average opened near USD 80.0/KG in Q1 2025 and closed at USD 74.91/KG in Q4, a full-year decline of about 6.4%. Synthesis intermediate cost softening and Chinese API supply adequacy maintained downward pressure before the H1 2026 recovery.
Clofazimine Prices in the United States in 2025
US prices fell from about USD 90.5/KG in Q1 2025 to USD 86.2/KG by Q4, a decline of 4.8%. Synthesis cost softening and adequate API supply maintained the downward trend.
Clofazimine Prices in China in 2025
Chinese prices fell from roughly USD 62.8/KG in Q1 2025 to USD 59.8/KG by Q4, a decline of 4.8%. Domestic API capacity and competitive pricing maintained the lowest level throughout.
Clofazimine Prices in Germany in 2025
German prices fell from about USD 111.5/KG in Q1 2025 to USD 106.2/KG by Q4, a decline of 4.8%. Synthesis intermediate cost softening and moderated European MDR-TB procurement maintained the decline through the year.
Clofazimine Prices in India in 2025
Indian prices fell from roughly USD 85.2/KG in Q1 2025 to USD 81.1/KG by Q4, a decline of 4.8%. Synthesis import cost softening and competitive export API pricing maintained downward pressure.
How We Can Help
Expert Market Research: Your Source for Real-Time Clofazimine Price Intelligence
Expert Market Research tracks Clofazimine prices continuously across every major producing and consuming region. The team traces causation through riminophenazine synthesis intermediate economics, WHO leprosy MDT and MDR-TB treatment procurement cycles, and regional API production capacity. Contact Expert Market Research today for Clofazimine pricing data, bespoke market analysis, and strategic procurement advisory.
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Key Questions Answered in the Report
WHO multidrug therapy programmes for leprosy elimination take the largest share, where clofazimine is a mandatory component of multibacillary and paucibacillary treatment regimens procured through WHO donation programmes and national elimination campaigns. MDR-TB and extensively drug-resistant TB treatment regimens endorsed by WHO guidance, and non-tuberculous mycobacterial infection management in immunocompromised patients, also consume significant volumes globally.
The Q2 2026 average was USD 95.9/KG in the United States, USD 66.6/KG in China, USD 118.1/KG in Germany, and USD 90.2/KG in India. Germany remains the highest-priced market.
The global average rose from USD 77.91/KG in Q1 to about USD 83.36/KG in Q2, a gain of around 7.0%. Recovering WHO leprosy MDT and MDR-TB programme procurement and firmer synthesis intermediate costs drove the H1 2026 recovery from the H2 2025 softening.
Riminophenazine synthesis intermediate cost softening reduced the API production floor. Moderated WHO leprosy MDT and MDR-TB programme procurement and Chinese API supply adequacy maintained downward pressure before the H1 2026 recovery.
The global average is expected in the USD 84.20 to 92.80/KG range for H2 2026, with continued firming as synthesis costs stay elevated and WHO leprosy MDT and MDR-TB treatment programme demand grows.
Germany sits highest on synthesis and energy costs, the United States and India hold a firm middle on MDR-TB and leprosy MDT demand, and China prices lowest on domestic API production capacity.
This report is updated monthly. For real-time pricing intelligence, contact the Expert Market Research team directly.
Prices respond mainly to riminophenazine synthesis intermediate costs, WHO leprosy MDT and MDR-TB treatment programme procurement cycles, and global leprosy and drug-resistant TB burden data. WHO funding commitments and MDR-TB guideline updates are key demand signals.
China and India hold the largest clofazimine API synthesis capacity. Any riminophenazine synthesis intermediate cost shift ripples across markets within one to two quarters.
Buyers can use quarterly trends and forecasts to time leprosy MDT and MDR-TB treatment formulation contracts around synthesis cost cycles, build cover when intermediate signals tighten, and monitor WHO programme funding and MDR-TB treatment guideline updates as primary demand signals.
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