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Doxepin Hydrochloride Prices, Demand and Supply Overview
Doxepin Hydrochloride prices in Germany, the highest-cost reporting region, rose 5.9% in H1 2026, climbing from USD 54.1/KG in Q1 to USD 57.3/KG by Q2 as recovering antidepressant, insomnia treatment, and chronic urticaria formulation procurement and firmer dibenzoxepin synthesis intermediate costs reversed the brief Q3 2025 API market softening. Globally, the average rose from USD 39.14/KG in Q1 to USD 41.49/KG in Q2, a 6.0% gain. For H2 2026, a global average of USD 41.80-46.20/KG is expected, with continued firming on Middle East supply disruptions and growing antidepressant and insomnia treatment sector demand globally.
Doxepin Hydrochloride is a dibenzoxepin tricyclic antidepressant produced by synthesis from 6,11-dihydrodibenz[b,e]oxepin precursors through condensation with 3-chloropropyl-dimethylamine and hydrochloride salt formation to yield the 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine hydrochloride as a mixture of E and Z geometric isomers. The compound exerts antidepressant and anxiolytic effects through inhibition of norepinephrine and serotonin reuptake transporters in central synapses, and produces marked sedative activity through potent histamine H1 receptor antagonism that underlies its utility in insomnia and pruritic conditions. The largest pull comes from major depressive disorder and generalised anxiety disorder treatment, where its combined noradrenergic and serotonergic profile and sedative properties support prescribing in patients with comorbid insomnia or anxious depression. Low-dose oral formulations of 3 to 6 milligrams for chronic insomnia maintenance, capitalising on H1 antagonism without residual daytime sedation at these low doses, add a growing segment. Topical cream for chronic pruritus in eczema and dermatological conditions and chronic urticaria management add further consistent demand. Synthesis intermediate costs, antidepressant prescription volumes, and regional API capacity all feed into the price.
Doxepin Hydrochloride Price Forecast for 2026
The balance of supply and demand for Doxepin Hydrochloride through H2 2026 leans moderately firm. Dibenzoxepin synthesis intermediate costs firmed from Middle East chemical supply disruptions. Antidepressant prescribing volumes, low-dose insomnia formulation demand, and topical dermatological procurement are growing with expanding mental health treatment access and sleep disorder awareness.
The main upside risk is synthesis intermediate cost increases alongside accelerating mental health treatment access programme procurement. The main downside risk is continued Chinese and Indian API surplus and generic competition limiting the global price recovery below forecast.
| Region | Price Forecast (USD/KG) | Key Driver |
| Global Average | 41.80 - 46.20 | Synthesis cost firming and antidepressant/insomnia demand support |
| United States | 44.60 - 49.00 | Steady antidepressant and insomnia treatment demand holds firm |
| China | 30.80 - 35.20 | Large API capacity keeps it the most affordable |
| Germany | 57.70 - 62.10 | High synthesis and energy costs keep it the most expensive |
| India | 42.50 - 46.90 | Growing antidepressant and export demand holds a firm middle |
For the Quarter Ending June 2026
Doxepin Hydrochloride Prices Q2 2026:
- United States: USD 46.7/KG
- China: USD 32.2/KG
- Germany: USD 57.3/KG
- India: USD 44.3/KG
Doxepin Hydrochloride Prices in the United States
US Doxepin Hydrochloride prices averaged USD 46.7/KG in Q2 2026, up 5.9% from USD 44.1/KG in Q1 2026. Firmer synthesis intermediate costs and recovering antidepressant and insomnia treatment procurement drove consistent buying through the quarter.
Why did the price of Doxepin Hydrochloride change in Q2 2026 in the United States?
Firmer dibenzoxepin synthesis intermediate costs raised the API production floor. Antidepressant, low-dose insomnia, and chronic urticaria treatment procurement lifted buying. Topical pruritus cream formulation demand provided additional buying support near USD 46.7/KG.
Doxepin Hydrochloride Prices in China
Chinese Doxepin Hydrochloride prices averaged USD 32.2/KG in Q2 2026, up 5.9% from USD 30.4/KG in Q1 2026, the lowest among the tracked markets. Spring antidepressant and insomnia export and domestic procurement lifted buying. Firmer domestic synthesis costs raised the floor despite domestic API capacity.
Why did the price of Doxepin Hydrochloride change in Q2 2026 in China?
Spring antidepressant and insomnia treatment export and domestic procurement lifted buying. Firmer domestic synthesis intermediate costs raised the production floor. Domestic API capacity kept China the most affordable source.
Doxepin Hydrochloride Prices in Germany
German Doxepin Hydrochloride prices averaged USD 57.3/KG in Q2 2026, up 5.9% from USD 54.1/KG in Q1 2026, the highest among the tracked markets. Higher synthesis intermediate and energy costs elevated European API production economics. Consistent antidepressant, insomnia, and topical dermatological demand maintained buying.
Why did the price of Doxepin Hydrochloride change in Q2 2026 in Germany?
Higher dibenzoxepin synthesis intermediate and energy costs elevated European API production economics. Middle East supply disruptions added cost premiums to synthesis substrate chains. Consistent antidepressant, insomnia, and dermatological procurement maintained buying near USD 57.3/KG.
Doxepin Hydrochloride Prices in India
Indian Doxepin Hydrochloride prices averaged USD 44.3/KG in Q2 2026, up 6.0% from USD 41.8/KG in Q1 2026. Growing antidepressant export and domestic insomnia treatment demand supported buying. Firmer synthesis import costs raised the production floor.
Why did the price of Doxepin Hydrochloride change in Q2 2026 in India?
Growing antidepressant and insomnia treatment export and domestic procurement lifted buying. Firmer dibenzoxepin synthesis import costs raised the production floor. Topical dermatological export demand provided additional buying support near USD 44.3/KG.
For the Quarter Ending March 2026
Doxepin Hydrochloride Prices Q1 2026:
- United States: USD 44.1/KG
- China: USD 30.4/KG
- Germany: USD 54.1/KG
- India: USD 41.8/KG
Doxepin Hydrochloride Prices in the United States
US Doxepin Hydrochloride prices averaged USD 44.1/KG in Q1 2026, recovering about 2.1% from Q4 2025. Recovering antidepressant and insomnia treatment demand and firming synthesis costs held the market near USD 44.1/KG.
Why did the price of Doxepin Hydrochloride change in Q1 2026 in the United States?
Recovering antidepressant, insomnia, and dermatological procurement maintained buying. Firming dibenzoxepin synthesis intermediate costs raised the production floor. The market recovered to USD 44.1/KG from the Q3 2025 API softening.
Doxepin Hydrochloride Prices in China
Chinese prices averaged USD 30.4/KG in Q1 2026, recovering about 2.0% from Q4 2025. Post-Lunar New Year antidepressant restocking and firming synthesis costs held the market near USD 30.4/KG.
Why did the price of Doxepin Hydrochloride change in Q1 2026 in China?
Post-Lunar New Year antidepressant export and domestic restocking lifted buying. Firming domestic synthesis intermediate costs raised the production floor. The market recovered to USD 30.4/KG from the Q3 2025 API softening.
Doxepin Hydrochloride Prices in Germany
German prices averaged USD 54.1/KG in Q1 2026, recovering about 2.1% from Q4 2025. Recovering antidepressant and insomnia demand and firming synthesis and energy costs held the market near USD 54.1/KG.
Why did the price of Doxepin Hydrochloride change in Q1 2026 in Germany?
Recovering antidepressant and insomnia formulation procurement maintained buying. Firming synthesis intermediate and energy costs held the production floor. The market recovered to USD 54.1/KG from the Q3 2025 API softening.
Doxepin Hydrochloride Prices in India
Indian prices averaged USD 41.8/KG in Q1 2026, recovering about 1.9% from Q4 2025. Growing antidepressant and insomnia treatment demand and firming import costs held the market near USD 41.8/KG.
Why did the price of Doxepin Hydrochloride change in Q1 2026 in India?
Growing antidepressant and insomnia export and domestic procurement maintained buying. Firming synthesis import costs raised the floor. The market recovered to USD 41.8/KG from the Q3 2025 level.
Quarterly Doxepin Hydrochloride Price Trends
Global Doxepin Hydrochloride prices dipped briefly in Q3 2025 on API synthesis cost softening before recovering steadily through Q4 2025, Q1 2026, and Q2 2026. The average eased from USD 38.0/KG in Q2 2025 to USD 37.62/KG in Q3, then firmed to USD 38.37/KG in Q4, USD 39.14/KG in Q1 2026, and USD 41.49/KG in Q2 2026, a net gain of about 9.2% over the window. Dibenzoxepin synthesis intermediate cost cycles and antidepressant and insomnia treatment demand drove the consistent recovery.
| Quarter | Price (USD/KG) | QoQ Change | Direction |
| Q2 2026 | 41.49 | +6.0% | ↑ Rising |
| Q1 2026 | 39.14 | +2.0% | ↑ Rising |
| Q4 2025 | 38.37 | +2.0% | ↑ Rising |
| Q3 2025 | 37.62 | -1.0% | ↓ Falling |
| Q2 2025 | 38.0 | - | - Stable |
| Q3 2026 | In Progress | - | - In Progress |
What was Doxepin Hydrochloride Price in 2025?
Doxepin Hydrochloride prices declined modestly through 2025 on API synthesis cost softening. The global average opened near USD 38.5/KG in Q1 2025 and closed at USD 38.37/KG in Q4, a marginal full-year decline of about 0.3%. Dibenzoxepin synthesis intermediate cost softening and consistent antidepressant and insomnia treatment demand maintained stable market conditions through most of the year.
Doxepin Hydrochloride Prices in the United States in 2025
US prices fell from about USD 44.0/KG in Q1 2025 to USD 43.2/KG by Q4, a decline of 1.8%. Synthesis cost softening and adequate API supply maintained modest downward pressure.
Doxepin Hydrochloride Prices in China in 2025
Chinese prices fell from roughly USD 30.5/KG in Q1 2025 to USD 29.8/KG by Q4, a decline of 2.3%. Domestic API capacity and competitive generic pricing maintained the lowest level throughout.
Doxepin Hydrochloride Prices in Germany in 2025
German prices fell from about USD 54.2/KG in Q1 2025 to USD 53.0/KG by Q4, a decline of 2.2%. Synthesis intermediate cost softening and moderate European antidepressant procurement maintained the downward trend.
Doxepin Hydrochloride Prices in India in 2025
Indian prices fell from roughly USD 41.8/KG in Q1 2025 to USD 41.0/KG by Q4, a decline of 1.9%. Synthesis import cost softening maintained modest downward pressure through the year.
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Expert Market Research: Your Source for Real-Time Doxepin Hydrochloride Price Intelligence
Expert Market Research tracks Doxepin Hydrochloride prices continuously across every major producing and consuming region. The team traces causation through dibenzoxepin synthesis intermediate economics, antidepressant and insomnia treatment prescription cycles, and regional API production capacity. Contact Expert Market Research today for Doxepin Hydrochloride pricing data, bespoke market analysis, and strategic procurement advisory.
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Key Questions Answered in the Report
Major depressive disorder and generalised anxiety disorder treatment with combined noradrenergic and serotonergic reuptake inhibition and sedative properties takes the largest share. Low-dose oral formulations for chronic insomnia maintenance treatment, topical cream for chronic pruritus management in eczema and dermatological conditions, and chronic urticaria treatment also consume significant volumes globally.
The Q2 2026 average was USD 46.7/KG in the United States, USD 32.2/KG in China, USD 57.3/KG in Germany, and USD 44.3/KG in India. Germany remains the highest-priced market.
The global average rose from USD 39.14/KG in Q1 to about USD 41.49/KG in Q2, a gain of around 6.0%. Recovering antidepressant and insomnia demand and firmer synthesis intermediate costs drove the H1 firming from the Q3 2025 API dip.
Dibenzoxepin synthesis intermediate cost moderation eased the API production floor. Seasonal antidepressant and insomnia formulation procurement moderation reduced buying urgency before the Q4 2025 and H1 2026 recovery.
The global average is expected in the USD 41.80 to 46.20/KG range for H2 2026, with continued firming as synthesis costs stay elevated and antidepressant and insomnia treatment demand grows globally.
Germany sits highest on synthesis and energy costs, the United States and India hold a firm middle on antidepressant and insomnia demand, and China prices lowest on domestic API capacity.
This report is updated monthly. For real-time pricing intelligence, contact the Expert Market Research team directly.
Prices respond mainly to dibenzoxepin synthesis intermediate costs, antidepressant and insomnia prescription volume cycles, and mental health treatment access expansion. Synthesis precursor prices and mental health guideline update data are key signals.
China and India hold the largest doxepin hydrochloride API synthesis capacity. Any synthesis intermediate cost shift ripples across markets within one to two quarters.
Buyers can use quarterly trends and forecasts to time antidepressant and insomnia formulation contracts around synthesis cost cycles, build cover when intermediate signals tighten, and monitor mental health prescription volume data as the primary demand signal.
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