Report Overview

2023

Base Year

2017-2023

Historical Year

2024-2032

Forecast Year

Acute Lymphoblastic Leukemia Therapeutics Market Outlook

The acute lymphoblastic leukemia therapeutics market size was valued at USD 2.79 billion in 2023, driven by increasing demand of personalised treatment across the major markets. The market is expected to grow at a CAGR of 4.6% during the forecast period of 2024-2032, with the values likely to rise from USD 2.79 billion in 2024 to USD 4.19 billion by 2032.

Acute Lymphoblastic Leukemia Therapeutics Market Overview

Acute lymphoblastic leukemia (ALL) is a cancer of blood and bone marrow, specifically affecting the lymphocytes (white blood cells). It is the most common type of cancer in children but can also occur in adults. It accounts for 74% of the overall pediatric leukemia cases. The risk of developing the disease gradually declines until the mid-20s and begins to rise after a person attains the age of 50. ALL affects approximately 4 out of every 10 adults. While most cases affect children, the death rate is significantly higher in adults (about 4 out of 5).

Acute lymphoblastic leukemia therapeutics market demand is driven by the rising incidence of the disease in recent years. As per data released by the American Cancer Society in 2023, around 6,540 new ALL cases are expected to affect the United States population, out of which 3,660 cases are expected in males and 2,880 cases in females. The deaths associated with the disease are projected to be around 1,390 (700 in males and 690 in females). While it is not a common cancer, the average person’s lifetime risk of developing the disease is 1 in 1,000. The male community is more  susceptible to this category of tumor than the females.

Global Acute Lymphocytic/Lymphoblastic Leukaemia (ALL) Therapeutics Market

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Surge in Combination Therapies for Personalized Treatment

The acute lymphoblastic leukemia therapeutics market share is expected to be dominated by combination therapies, owing to their efficacy in reducing tumor progression and minimizing other side effects associated with the condition. In January 2023, the results of a clinical trial revealed that blinatumomab (Blincyto), when combined with chemotherapy, showed 83% improvement in the survival rate as opposed to those who were subjected to chemotherapy alone (65%).

Growth in Immunotherapy and Targeted Therapies to Drive the Market Growth

With the rising popularity of targeted therapy to treat cancer, a class of tyrosine kinase inhibitors (TKI) has been found effective in treating newly diagnosed ALL in patients. One such example is Takeda Pharmaceutical’s Ponatinib , which is currently under phase I trial for pediatric Ph+ acute lymphoblastic leukemia. It prevents tumor progression by blocking BCR-ABL protein.

Asparaginase therapies are also considered as critical treatment alternative for acute lymphoblastic leukemia. Currently, the FDA has approved five asparaginase therapies. Owing to its reduced immunogenicity compared to native E. coli preparations and satisfactory pharmacokinetic profile, pegaspargase is used as the firsthand asparaginase therapeutic option. To meet the rising acute lymphoblastic leukemia therapeutics market demand, regulatory authorities around the world are approving new drug therapies for treatment.

In July 2023, the European Medicines Agency (EMA) showed a positive opinion on the authorization of marketing Jazz Pharmaceutical’s  JZP458 (a recombinant Erwinia asparaginase or crisantaspase) in the region. L -asparaginase lowers the serum levels of L-asparagine, resulting in cell death. This is because the enzyme is present in the human body and not naturally synthesized by the leukemic cells. It is expected to be used as a constituent of a multi-agent chemotherapeutic routine for the treatment of acute lymphoblastic leukemia in adults as well as children who have developed silent inactivation or hypersensitivity to E. coli derived asparaginase.

Emphasis on Cancer Recurrence

Preventing recurrence of acute lymphoblastic leukemia is a key area of investigation amongst scientists. Hence, there is an emphasis on pairing standard leukemia treatments with new class of drugs to prevent relapse. In addition, immune checkpoint blockade that disrupts the pathway used by cancer cells to evade the immune system are also being evaluated in clinical trials. The search for new technologies and alternatives, coupled with improving technical advancements, is expected to support the acute lymphoblastic leukemia therapeutics market size in the forecast period.

Global Acute Lymphocytic/Lymphoblastic Leukaemia (ALL) Therapeutics Market By Therapy Type

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Acute Lymphoblastic Leukemia Therapeutics Market Segmentation

Market Breakup by Type

  • Bone Marrow Transplant
  • B-cell Acute Lymphoblastic Leukemia
  • C-cell Acute Lymphoblastic Leukemia

Market Breakup by Treatment

  • Chemotherapy
  • Radiation Therapy
  • Targeted Therapy
  • Immunotherapy
  • Others

Market Breakup by Patient Type

  • Adult
  • Pediatric

Market Breakup by Route of Administration

  • Oral
  • Parenteral

Market Breakup by Distribution Channel

  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy
  • Others

Market Breakup by Region

  • United States
  • EU-4 and the United Kingdom
    • Germany
    • France
    • Italy
    • Spain
    • United Kingdom
  • Japan

Global Acute Lymphocytic/Lymphoblastic Leukaemia (ALL) Therapeutics Market By Region

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Acute Lymphoblastic Leukemia Therapeutics Market Regional Analysis

The United States, with a well-established medical and research infrastructure is expected to lead the acute lymphoblastic leukemia therapeutics market share in upcoming years. The market size is further fueled by the inauguration of research centers with a vision to encourage research and innovation. In September 2023, Cincinnati Children's Hospital launched advanced leukemia therapies and research center that aims to integrate more research and clinical programs for improved patient outcomes.

Acute Lymphoblastic Leukemia Therapeutics Market: Competitor Landscape

In December 2023, Theseus Pharmaceuticals  entered a merger agreement with Concentra Biosciences wherein the company will acquire Theseus Pharmaceuticals for a stock price of USD 3.90 and USD 4.05 in cash. The merger is focused on improving the lives of cancer patients with discovery, commercialization, and development of transformative targeted therapies.

In March 2023, Pfizer  acquired Seagen for USD 43 billion to develop antibody drug candidates, a pioneer in the cancer class drugs. Such acquisitions are a clear indicator that the market for cancer therapeutics is anticipated to witness substantial growth in the forecast period.

The key features of the acute lymphoblastic leukemia therapeutics market report include patent analysis, grants analysis, clinical trials analysis, funding and investment analysis, partnerships, and collaborations analysis by the leading key players. The major companies in the market are as follows:

  • Novartis AG
  • F. Hoffmann-La Roche Ltd
  • Eisai Co Ltd
  • GlaxoSmithKline plc.
  • Celegene Corporation
  • Bristol Myer Squibb Company
  • Pfizer Inc.
  • Sanofi SA
  • Genmab A/S
  • Erytech Pharma
  • Takeda Pharmaceutical Company Limited
  • OBI Pharma
  • Astellas Pharma Inc.
  • Medexus Pharma, Inc.
  • Kiadis Pharma

Kindly note that this only represents a partial list of companies, and the complete list has been provided in the report.

Key Highlights of the Report

REPORT FEATURES DETAILS
Base Year 2023
Historical Period 2017-2023
Forecast Period 2024-2032
Scope of the Report

Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:

  • Type
  • Treatment
  • Patient Type
  • Route of Administration
  • Distribution Channel
  • Region
Breakup by Type
  • B-cell Acute Lymphoblastic Leukemia
  • C-cell Acute Lymphoblastic Leukemia
Breakup by Treatment
  • Chemotherapy
  • Radiation Therapy
  • Bone Marrow Transplant
  • Targeted Therapy
  • Immunotherapy
  • Others
Breakup by Patient Type
  • Adult
  • Pediatric
Breakup by Route of Administration
  • Oral
  • Parenteral
Breakup by Distribution Channel
  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy
  • Others
Breakup by Region
  • EU-4 and the United Kingdom
  • Germany
  • Japan
Market Dynamics
  • Market Drivers and Constraints
  • SWOT Analysis
  • Porter’s Five Forces Model 
  • Key Demand Indicators
  • Key Price Indicators
  • Industry Events, Initiatives, and Trends 
  • Value Chain Analysis
Competitive Landscape
  • Market Structure
  • Company Profiles
    • Financial Analysis
    • Product Portfolio
    • Demographic Reach and Achievements
    • Mergers and Acquisitions
    • Certifications
Companies Covered
  • Novartis AG
  • F. Hoffmann-La Roche Ltd
  • Eisai Co Ltd
  • GlaxoSmithKline plc.
  • Celegene Corporation
  • Bristol Myer Squibb Company
  • Pfizer Inc.
  • Sanofi SA
  • Genmab A/S
  • Erytech Pharma
  • Takeda Pharmaceutical Company Limited
  • OBI Pharma
  • Astellas Pharma Inc.
  • Medexus Pharma, Inc.
  • Kiadis Pharma

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Key Questions Answered in the Report

The market attained a value of about USD 2.79 billion in 2023, driven by the increasing demand for personalised treatment across the major markets.

The market is anticipated to grow at a CAGR of 4.6% during the forecast period of 2024-2032, likely to reach a market value of USD 4.19 billion by 2032.

The market demand is driven by the increasing incidence of the disease in adults as well as children in recent years, along with surge in investments on research and development and rising partnerships amongst vital healthcare companies.

The major market trend revolves around using innovative alternatives such as immune checkpoint blockades and combining standard leukemia treatments with new class of drugs to prevent cancer recurrence.

Based on patient types, the market is divided into adults and paediatrics.

Based on disease type, the market is divided into B-cell acute lymphoblastic leukemia and C-cell acute lymphoblastic leukemia.

Chemotherapy, radiation therapy, bone marrow transplant, targeted therapy, and immunotherapy, among others are common technologies available in the market.

Major distribution channels include hospital pharmacy, retail pharmacy, and online pharmacy, among others.

The routes of administration can be oral and parenteral.

The major regions of the market include the United States, Japan, EU-4 which is segmented into Germany, France, Italy, Spain, and the United Kingdom.

Key players involved in the market are Novartis AG, F. Hoffmann-La Roche Ltd, Eisai Co Ltd., GlaxoSmithKline plc., Celegene Corporation, Bristol Myer Squibb Company, Pfizer Inc., Sanofi SA, Genmab A/S, Erytech Pharma, Takeda Pharmaceutical Company Limited, OBI Pharma, Astellas Pharma Inc., Medexus Pharma, Inc., and Kiadis Pharma.

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