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The Australia pulmonary arterial hypertension drugs market was valued at USD 173.91 Million in 2025 and is expected to grow at a CAGR of 4.20%, reaching USD 262.42 Million by 2035. The market growth is supported by increasing adoption of advanced PAH therapies, including prostacyclin analogs and endothelin receptor antagonists. Growing awareness among healthcare providers and patients, along with government reimbursement policies, is boosting treatment accessibility. Ongoing clinical trials and research into novel therapies for early diagnosis and management are expected to enhance market growth during the forecast period.
Base Year
Historical Period
Forecast Period
The growth in the market is driven by increasing pulmonary arterial hypertension prevalence, advancements in diagnostic capabilities, and rising adoption of targeted pharmacological treatments.
Several key trends in the market include the development of combination therapy approaches and sustained investment in novel drug classes.
The leading players in the market are accelerating growth through innovative product introductions, strategic partnerships, and enhanced treatment accessibility.
Compound Annual Growth Rate
4.2%
Value in USD Million
2026-2035
*this image is indicative*
Pulmonary arterial hypertension drugs are advanced therapeutic agents aimed at improving hemodynamic function and reducing disease progression by targeting vascular remodeling and pulmonary vasoconstriction pathways. The market is driven by increased disease awareness, improved diagnostics, and the adoption of innovative therapies. The market was valued at USD 173.91 Million in 2025, supported by strong healthcare infrastructure and government initiatives enhancing patient access to treatment. Rising investment in research and development is further expected to expand the therapeutic landscape in the coming years.
Rising Disease Prevalence to Drive the Market Expansion in Australia
The increasing prevalence of pulmonary arterial hypertension (PAH) is a key growth driver in the Australian market. According to Shuoshuo Wei et al. (2025), registry-based studies indicate notable geographic variations, with Central Australia recording a higher prevalence of 48 cases per million, compared to approximately 25 per million in the United States. The Global Burden of Diseases (GBD) study further reported in 2021 an age-standardized prevalence of 2.28 per 100,000 and a higher impact among women and elderly populations. This growing disease burden is anticipated to significantly boost demand for PAH drugs in Australia.
Some of the trends in the market include the growing use of combination therapies and the increasing adoption of advanced endothelin receptor antagonists.
Combination Therapies Driving Innovation in the Pulmonary Arterial Hypertension Drugs Market in Australia
The market is witnessing a growing trend toward fixed-dose combination therapies, aiming to improve treatment adherence and patient outcomes. In September 2024, a notable development was the approval of a macitentan and tadalafil combination tablet, offering a simplified once-daily regimen for eligible patients. Such advancements enhance convenience by replacing multiple pills with a single formulation, supporting long-term disease management. This shift toward combination therapies is expected to boost market value by addressing unmet needs and improving therapeutic efficiency.
Rising Adoption of Advanced Endothelin Receptor Antagonists to Boost Australia Pulmonary Arterial Hypertension Drugs Market Value
The increasing adoption of advanced endothelin receptor antagonists, driven by the need for effective long-term management of PAH and associated comorbidities, is a growing trend in the market. In September 2024, updated treatment information for Bosentan highlighted its role in addressing PAH related to conditions such as scleroderma, reinforcing its clinical relevance. Growing emphasis on early diagnosis, improved therapeutic monitoring, and the integration of targeted drug therapies is expected to significantly enhance the market’s growth trajectory in the coming years.
Endothelin Receptor Antagonists Poised to Dominate Market Share by Drug Class
The market encompasses various drug classes, including endothelin receptor antagonists (ERAs), soluble guanylate cyclase (SGC) stimulators, phosphodiesterase Type 5 (PDE-5) inhibitors, prostacyclin and prostacyclin analogs, and others. Among these, ERAs are expected to lead the market, driven by their proven efficacy in improving exercise capacity, delaying disease progression, and their widespread adoption as a first-line therapy in clinical practice. Strong clinical evidence and expanding patient access further reinforce their dominant position in the market.
The key features of the market report comprise clinical trials analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the market are as follows:
Bayer is the manufacturer of riociguat (Adempas®), a soluble guanylate cyclase stimulator that is approved in Australia for treating pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Through its Australian subsidiary, Bayer participates in government subsidy schemes (e.g. PBS Highly Specialised Drugs) enabling access for PAH patients in specialist settings. Its role is as innovator and supplier of newer mechanism drugs that broaden the therapeutic options beyond traditional endothelin receptor antagonists and prostacyclins in Australia.
Teva operates in Australia largely via its generic and specialty medicines business. In the PAH drugs market, Teva’s involvement comes mainly from supplying generic versions of PAH-agents (e.g. ambrisentan generics) that have been approved in Australia by the TGA. These generics help widen access by lowering cost and increasing treatment options under the Pharmaceutical Benefits Scheme.
Eli Lilly is an innovator pharmaceutical company with involvement in PAH through supply of tadalafil (originally developed by Lilly) for PAH (often in combination therapy) and collaboration in clinical trials involving dual-therapy regimens. Although the specific PAH product branding and PBS subsidy may involve partners, Lilly plays a role in bringing forward therapies that combine its molecules (like tadalafil) as part of treatment guidelines in Australia.
GlaxoSmithKline (GSK) markets ambrisentan (Volibris®) in Australia, an endothelin receptor antagonist used to treat PAH in patients with WHO functional class II–IV symptoms. Ambrisentan has orphan drug designation in Australia, helping in its regulatory path. Through GSK’s involvement, Australian clinicians have access to non-prostanoid, oral ERA therapy, which is an important class in PAH management.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other key players in the market include Pfizer Inc., Amgen Inc., and Novartis AG, among others.
The market report offers a detailed analysis of the market based on the following segments:
Market Breakup by Drug Class
Market Breakup by Route of Administration
Market Breakup by Type
Market Breakup by Distribution Channel
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Drug Class |
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| Breakup by Route of Administration |
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| Breakup by Type |
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| Breakup by Distribution Channel |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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