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Global Biosimulation Market Size, Share, Growth, Report: By Product and Services: Software, Services; By Delivery Model: Subscription Model, Ownership Model; By Application: Drug Discovery, Drug Development, Others; By End User: Pharmaceutical and Biotechnology Companies, Others; Regional Analysis; Supplier Landscape; 2024-2032
Global Biosimulation Market Outlook
The global biosimulation market size was valued at USD 3.5 billion in 2023, driven by the technological innovations in the biosimulation software across the globe. The market is expected to grow at a CAGR of 16.90% during the forecast period of 2024-2032, with the values likely to rise from USD 4.1 billion in 2024 to USD 14.1 billion by 2032.
Key Takeaways
- Recent data predicts that cancer incidence is expected to rise, reaching 35 million new cases by 2050. Biosimulation stands as a promising strategy to accelerate oncology drug development to meet the growing clinical needs of cancer patients.
- In March 2023, Certara, Inc., launched Simcyp Simulator Version 22, a physiologically based pharmacokinetics (PBPK) platform with updated features and novel capabilities for drug development processes.
- Technological advancement and upgradation in biosimulation software including integration of machine learning and artificial intelligence (AI) are projected to augment market demand in the forecast period.
Biosimulation, a relatively new tool in healthcare and pharmaceutical drug development, allows researchers to simulate complex biological systems. It helps to predict drug behavior, reduces costs and time as compared to conventional experiments, and optimizes treatment strategies. These factors are likely to augment biosimulation market growth in coming years.
The rising adoption of biosimulation software by key market players can be attributed to its ability to predict clinical outcomes before the occurrence of human clinical trials. This approach not only expedites drug development timelines but also minimizes risks associated with failed trials. Such factors fuel the rising market demand. Moreover, the rise in healthcare expenditure and technological advancements in the field are also expected to fuel the market share.
Global Biosimulation Market Trends and Developments
Advancements in computational power, growing focus on chronic diseases, increasing demand for personalized medicine, and expansion in biosimulation applications comprise some of the key trends and developments in the market.
| Date | Company | Event |
| December 2023 | Certara, Inc . | Certara acquired Applied Biomath, an innovative biotechnology company to industrialize quantitative systems pharmacology (QSP) biosimulation methods. Utilizing the expertise of Applied Biomath, the company intends to expand biosimulation capabilities including predicting the optimal dosing regimen for novel therapies. |
| June 2023 | Simulations Plus, Inc. | Simulations Plus Inc. acquired Immunetrics Inc. (a odelling and simulation company specializing in oncology, immunology, and autoimmune diseases) at a deal worth USD 15.5 million in cash along with USD 1.8 million hold-back, and USD 8 million depending on revenue performance. The acquisition will reinforce the existing quantitative systems pharmacology (QSP) software and service capabilities at Simulations Plus, increasing the therapeutic areas covered via QSP models by 50%. |
| March 2023 | Certara, Inc. | The leading biosimulation company launched Simcyp Simulator Version 22, a physiologically based pharmacokinetics (PBPK) platform with updated features and novel capabilities for drug development processes. The company Simcyp Simulator has proven its utilization across 300 label claims for 90+ novel drugs, replacing the need for human clinical trials. |
| January 2023 | Cellworks | Cellworks announced the launch of two new business units, leveraging biosimulation for novel precision oncology drug testing to accelerate drug development timelines and reduce costs. Utilizing its biosimulation and computational model (CBM), the personalized therapy biosimulation company aims to predict patient response, streamline clinical trials, and aid in biomarker development, among others, potentially transforming the drug development process. |
| Key Trends | Impact |
| Advancements in Computational Power | Increased computational power and advancements in software capabilities are enabling more accurate biosimulation. This allows for biological simulation processes at a higher scale and speed, resulting in accelerated drug development timelines. |
| Growing Focus on Chronic Diseases | With the rising prevalence of chronic diseases, biosimulation is being leveraged to develop treatments for these conditions. Simulations help in predicting the long-term outcomes of therapies for chronic diseases. The predictive models also help in improving the design of clinical trials, leading to better patient care. Consequently, elevating the biosimulation market share positively. |
| Increasing Demand for Personalized Medicine | Biosimulation supports the development of personalized medicine by facilitating the simulation of drug responses based on individual genetic makeup. This market trend is expected to result in effective tailored treatment options, reducing the risk of adverse drug reactions. |
| Expansion in Biosimulation Applications | Beyond drug development, biosimulation is finding application in domains such as disease modelling, toxicology, and risk assessment of pharmaceuticals, demonstrating its expanded market reach. |
Factors Affecting Global Biosimulation Market Demand
As more and more pharmaceutical companies are recognising the significance of biosimulation software in expediting drug development processes, the market is witnessing major investments to integrate and improve simulation systems. The simulation models are increasingly employed to test drugs in a virtual environment before conducting expensive and time-consuming clinical trials, which is bolstering the biosimulation market value.
The market is also driven by the rising strategic partnerships between the leading market players, novel product launches, and the growing complexity of drug development fuelling the demand for biosimulation tools and services.
Global Biosimulation Market Segmentation
The market report offers a detailed analysis of the market based on the following segments:
| Market Breakup | Categories |
| Product and Services | Software (Molecular Modeling and Simulation Software, PBPK Modeling and Simulation Software, Trial Design Software, Toxicity Prediction Software, Other Biosimulation Software), Services (In-House Services and Contract Services) |
| Delivery Model | Subscription Model, Ownership Model |
| Application | Drug Discovery (Pre-Clinical Testing and Clinical Trials), Drug Development (Target Identification and Validation, Lead Identification and Optimization), Others |
| End User | Pharmaceutical and Biotechnology Companies, Contract Research Organization, Academic Research Institutes, Others |
| Region | North America, Europe, Asia Pacific, Latin America, Middle East, and Africa |
By product and services, the market includes software such as molecular modeling and simulation software, PBPK modeling and simulation software, trial design software, toxicity prediction software, and other specialized biosimulation software. Additionally, services offered in the biosimulation market comprise in-house services and contract services, catering to various needs of pharmaceutical and biotechnology companies.
The market is further segmented by delivery model into subscription model and ownership model. This market segment comprises different approaches to accessing biosimulation tools and services.
Applications of biosimulation market share include drug discovery and drug development among others. Drug discovery is further divided into pre-clinical testing and clinical trials, while drug development comprises target identification and validation, lead identification and optimization, among others. Biosimulation holds predictive modeling capabilities which facilitates data-driven insights into complex biological phenomena.
End-users of biosimulation technologies and services include pharmaceutical and biotechnology companies, contract research organizations, and academic research institutes, among others, involved in drug discovery and development.
Based on region, the market report covers North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. The market is witnessing growth driven by increasing demand for personalized medicine, advancements in technology, and rising healthcare expenditure. However, the level of market development and growth rates may vary from region to region.
Global Biosimulation Market: Competitive Landscape
The key market players are contributing to the biosimulation market growth through strategic mergers and acquisitions initiatives, novel product launches, and continuous R&D efforts aimed at technological advancement.
| Company | Year Founded | Headquarters | Products/Services |
| Certara Inc. | 2008 | Princeton, New Jersey, USA | Specializes in biosimulation software and consulting services for drug development such as pharmacokinetic/pharmacodynamic (PK/PD) modelling |
| Dassault Systemes | 1981 | Vélizy-Villacoublay, France | Offers a broad range of software applications for simulation, 3D design, and digital manufacturing, including BIOVIA modelling and simulation software. |
| Simulation Plus | 1996 | Lancaster, California, USA | Provides modelling and simulation software for pharmaceutical research and development, focusing on absorption, distribution, metabolism, excretion, and toxicity modelling |
| Schrodinger Inc. | 1990 | New York, USA | Provides software solutions and services for drug discovery, including a computational platform offering predictive modelling to assist molecular discovery |
Other key players in the market include Advanced Chemistry Development Inc., Physiomics PLC, Genedata AG, Thermo Fisher Scientific, Immunetrics, BioSimulation Consulting Inc., Yokogawa Insillico Biotechnology GmbH, and Chemical Computing Group ULC, among others.
Global Biosimulation Market Analysis by Region
North America is the leading regional market, owing to the presence of key players and advanced healthcare system which is witnessing rapid digitization. The higher adoption rates of in-silico models in drug development and discovery processes is also driving market growth. Moreover, the rising prevalence of chronic diseases in the region is expected to fuel the biosimulation market size in the forecast period.
Asia Pacific is projected to experience exponential growth which can be attributed to the rising research and development activities in the region. Further, the increased impetus of the government to improve healthcare infrastructure and patient outcomes is likely to boost the market size.
Key Highlights of the Report
| REPORT FEATURES | DETAILS |
| Base Year | 2023 |
| Historical Period | 2017-2023 |
| Forecast Period | 2024-2032 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Product and Services |
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| Breakup by Delivery Model |
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| Breakup by Application |
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| Breakup by End User |
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| Breakup by Region |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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*At Expert Market Research, we strive to always give you current and accurate information. The numbers depicted in the description are indicative and may differ from the actual numbers in the final EMR report.
1 Preface
1.1 Objectives of the Study
1.2 Key Assumptions
1.3 Report Coverage – Key Segmentation and Scope
1.4 Research Methodology
2 Executive Summary
3 Global Biosimulation Market Overview
3.1 Global Biosimulation Market Historical Value (2017-2023)
3.2 Global Biosimulation Market Forecast Value (2024-2032)
4 Global Biosimulation Market Landscape*
4.1 Global Biosimulation: Developers Landscape
4.1.1 Analysis by Year of Establishment
4.1.2 Analysis by Company Size
4.1.3 Analysis by Region
4.2 Global Biosimulation: Product Landscape
4.2.1 Analysis by Product and Services
4.2.2 Analysis by Delivery Model
4.2.3 Analysis by Applications
5 Global Biosimulation Market Dynamics
5.1 Market Drivers and Constraints
5.2 SWOT Analysis
5.2.1 Strengths
5.2.2 Weaknesses
5.2.3 Opportunities
5.2.4 Threats
5.3 Porter’s Five Forces Model
5.3.1 Bargaining Power of Suppliers
5.3.2 Bargaining Power of Buyers
5.3.3 Threat of New Entrants
5.3.4 Threat of Substitutes
5.3.5 Degree of Rivalry
5.4 Key Demand Indicators
5.5 Key Price Indicators
5.6 Industry Events, Initiatives, and Trends
5.7 Value Chain Analysis
6 Global Biosimulation Market Segmentation (2017-2032)
6.1 Global Biosimulation Market (2017-2032) by Product and Services
6.1.1 Market Overview
6.1.2 Software
6.1.2.1 Molecular Modeling and Simulation Software
6.1.2.2 PBPK Modeling and Simulation Software
6.1.2.3 Trial Design Software
6.1.2.4 Toxicity Prediction Software
6.1.2.5 Other Biosimulation Software
6.1.3 Services
6.1.3.1 In-House Services
6.1.3.2 Contract Services
6.2 Global Biosimulation Market (2017-2032) by Delivery Model
6.2.1 Market Overview
6.2.2 Subscription Model
6.2.3 Ownership Model
6.3 Global Biosimulation Market (2017-2032) by Application
6.3.1 Market Overview
6.3.2 Drug Discovery
6.3.2.1 Pre-Clinical Testing
6.3.2.2 Clinical Trials
6.3.3 Drug Development
6.3.3.1 Target Identification and Validation
6.3.3.2 Lead Identification and Optimization
6.3.4 Others
6.4 Global Biosimulation Market (2017-2032) by End User
6.4.1 Market Overview
6.4.2 Pharmaceutical and Biotechnology Companies
6.4.3 Contract Research Organization
6.4.4 Academic Research Institutes
6.4.5 Others
6.5 Global Biosimulation Market (2017-2032) by Region
6.5.1 Market Overview
6.5.2 North America
6.5.3 Europe
6.5.4 Asia Pacific
6.5.5 Latin America
6.5.6 Middle East and Africa
7 North America Biosimulation Market (2017-2032)
7.1 North America Biosimulation Market (2017-2032) by Product and Services
7.1.1 Market Overview
7.1.2 Software
7.1.2.1 Molecular Modeling and Simulation Software
7.1.2.2 PBPK Modeling and Simulation Software
7.1.2.3 Trial Design Software
7.1.2.4 Toxicity Prediction Software
7.1.2.5 Other Biosimulation Software
7.1.3 Services
7.1.3.1 In-House Services
7.1.3.2 Contract Services
7.2 North America Biosimulation Market (2017-2032) by Application
7.2.1 Market Overview
7.2.2 Drug Discovery
7.2.2.1 Pre-Clinical Testing
7.2.2.2 Clinical Trials
7.2.3 Drug Development
7.2.3.1 Target Identification and Validation
7.2.3.2 Lead Identification and Optimization
7.2.4 Others
7.3 North America Biosimulation Market (2017-2032) by Country
7.3.1 United States of America
7.3.2 Canada
8 Europe Biosimulation Market (2017-2032)
8.1 Europe Biosimulation Market (2017-2032) by Product and Services
8.1.1 Market Overview
8.1.2 Software
8.1.2.1 Molecular Modeling and Simulation Software
8.1.2.2 PBPK Modeling and Simulation Software
8.1.2.3 Trial Design Software
8.1.2.4 Toxicity Prediction Software
8.1.2.5 Other Biosimulation Software
8.1.3 Services
8.1.3.1 In-House Services
8.1.3.2 Contract Services
8.2 Europe Biosimulation Market (2017-2032) by Application
8.2.1 Market Overview
8.2.2 Drug Discovery
8.2.2.1 Pre-Clinical Testing
8.2.2.2 Clinical Trials
8.2.3 Drug Development
8.2.3.1 Target Identification and Validation
8.2.3.2 Lead Identification and Optimization
8.2.4 Others
8.3 Europe Biosimulation Market (2017-2032) by Country
8.3.1 United Kingdom
8.3.2 Germany
8.3.3 France
8.3.4 Italy
8.3.5 Others
9 Asia Pacific Biosimulation Market (2017-2032)
9.1 Asia Pacific Biosimulation Market (2017-2032) by Product and Services
9.1.1 Market Overview
9.1.2 Software
9.1.2.1 Molecular Modeling and Simulation Software
9.1.2.2 PBPK Modeling and Simulation Software
9.1.2.3 Trial Design Software
9.1.2.4 Toxicity Prediction Software
9.1.2.5 Other Biosimulation Software
9.1.3 Services
9.1.3.1 In-House Services
9.1.3.2 Contract Services
9.2 Asia Pacific Biosimulation Market (2017-2032) by Application
9.2.1 Market Overview
9.2.2 Drug Discovery
9.2.2.1 Pre-Clinical Testing
9.2.2.2 Clinical Trials
9.2.3 Drug Development
9.2.3.1 Target Identification and Validation
9.2.3.2 Lead Identification and Optimization
9.2.4 Others
9.3 Asia Pacific Biosimulation Market (2017-2032) by Country
9.3.1 China
9.3.2 Japan
9.3.3 India
9.3.4 ASEAN
9.3.5 Australia
9.3.6 Others
10 Latin America Biosimulation Market (2017-2032)
10.1 Latin America Biosimulation Market (2017-2032) by Product and Services
10.1.1 Market Overview
10.1.2 Software
10.1.2.1 Molecular Modeling and Simulation Software
10.1.2.2 PBPK Modeling and Simulation Software
10.1.2.3 Trial Design Software
10.1.2.4 Toxicity Prediction Software
10.1.2.5 Other Biosimulation Software
10.1.3 Services
10.1.3.1 In-House Services
10.1.3.2 Contract Services
10.2 Latin America Biosimulation Market (2017-2032) by Application
10.2.1 Market Overview
10.2.2 Drug Discovery
10.2.2.1 Pre-Clinical Testing
10.2.2.2 Clinical Trials
10.2.3 Drug Development
10.2.3.1 Target Identification and Validation
10.2.3.2 Lead Identification and Optimization
10.2.4 Others
10.3 Latin America Biosimulation Market (2017-2032) by Country
10.3.1 Brazil
10.3.2 Argentina
10.3.3 Mexico
10.3.4 Others
11 Middle East and Africa Biosimulation Market (2017-2032)
11.1 Middle East and Africa Biosimulation Market (2017-2032) by Product and Services
11.1.1 Market Overview
11.1.2 Software
11.1.2.1 Molecular Modeling and Simulation Software
11.1.2.2 PBPK Modeling and Simulation Software
11.1.2.3 Trial Design Software
11.1.2.4 Toxicity Prediction Software
11.1.2.5 Other Biosimulation Software
11.1.3 Services
11.1.3.1 In-House Services
11.1.3.2 Contract Services
11.2 Middle East and Africa Biosimulation Market (2017-2032) by Application
11.2.1 Market Overview
11.2.2 Drug Discovery
11.2.2.1 Pre-Clinical Testing
11.2.2.2 Clinical Trials
11.2.3 Drug Development
11.2.3.1 Target Identification and Validation
11.2.3.2 Lead Identification and Optimization
11.2.4 Others
11.3 Middle East and Africa Biosimulation Market (2017-2032) by Country
11.3.1 Saudi Arabia
11.3.2 United Arab Emirates
11.3.3 Nigeria
11.3.4 South Africa
11.3.5 Others
12 Regulatory Framework
12.1 Regulatory Overview
12.1.1 US FDA
12.1.2 EU EMA
12.1.3 INDIA CDSCO
12.1.4 JAPAN PMDA
12.1.5 Others
13 Patent Analysis
13.1 Analysis by Type of Patent
13.2 Analysis by Publication year
13.3 Analysis by Issuing Authority
13.4 Analysis by Patent Age
13.5 Analysis by CPC Analysis
13.6 Analysis by Patent Valuation
13.7 Analysis by Key Players
14 Grants Analysis
14.1 Analysis by Year
14.2 Analysis by Amount Awarded
14.3 Analysis by Issuing Authority
14.4 Analysis by Grant Application
14.5 Analysis by Funding Institute
14.6 Analysis by Departments
14.7 Analysis by Recipient Organization
15 Funding and Investment Analysis
15.1 Analysis by Funding Instances
15.2 Analysis by Type of Funding
15.3 Analysis by Funding Amount
15.4 Analysis by Leading Players
15.5 Analysis by Leading Investors
15.6 Analysis by Geography
16 Partnership and Collaborations Analysis
16.1 Analysis by Partnership Instances
16.2 Analysis by Type of Partnership
16.3 Analysis by Leading Players
16.4 Analysis by Geography
17 Supplier Landscape
17.1 Certara Inc.
17.1.1 Financial Analysis
17.1.2 Product Portfolio
17.1.3 Demographic Reach and Achievements
17.1.4 Mergers and Acquisitions
17.1.5 Certifications
17.2 Dassault Systemes
17.2.1 Financial Analysis
17.2.2 Product Portfolio
17.2.3 Demographic Reach and Achievements
17.2.4 Mergers and Acquisitions
17.2.5 Certifications
17.3 Simulation Plus
17.3.1 Financial Analysis
17.3.2 Product Portfolio
17.3.3 Demographic Reach and Achievements
17.3.4 Mergers and Acquisitions
17.3.5 Certifications
17.4 Schrodinger Inc.
17.4.1 Financial Analysis
17.4.2 Product Portfolio
17.4.3 Demographic Reach and Achievements
17.4.4 Mergers and Acquisitions
17.4.5 Certifications
17.5 Advanced Chemistry Development Inc.
17.5.1 Financial Analysis
17.5.2 Product Portfolio
17.5.3 Demographic Reach and Achievements
17.5.4 Mergers and Acquisitions
17.5.5 Certifications
17.6 Physiomics PLC
17.6.1 Financial Analysis
17.6.2 Product Portfolio
17.6.3 Demographic Reach and Achievements
17.6.4 Mergers and Acquisitions
17.6.5 Certifications
17.7 Genedata AG
17.7.1 Financial Analysis
17.7.2 Product Portfolio
17.7.3 Demographic Reach and Achievements
17.7.4 Mergers and Acquisitions
17.7.5 Certifications
17.8 Thermo Fisher Scientific
17.8.1 Financial Analysis
17.8.2 Product Portfolio
17.8.3 Demographic Reach and Achievements
17.8.4 Mergers and Acquisitions
17.8.5 Certifications
17.9 Immunetrics
17.9.1 Financial Analysis
17.9.2 Product Portfolio
17.9.3 Demographic Reach and Achievements
17.9.4 Mergers and Acquisitions
17.9.5 Certifications
17.10 BioSimulation Consulting Inc.
17.10.1 Financial Analysis
17.10.2 Product Portfolio
17.10.3 Demographic Reach and Achievements
17.10.4 Mergers and Acquisitions
17.10.5 Certifications
17.11 Yokogawa Insillico Biotechnology GmbH
17.11.1 Financial Analysis
17.11.2 Product Portfolio
17.11.3 Demographic Reach and Achievements
17.11.4 Mergers and Acquisitions
17.11.5 Certifications
17.12 Chemical Computing Group ULC
17.12.1 Financial Analysis
17.12.2 Product Portfolio
17.12.3 Demographic Reach and Achievements
17.12.4 Mergers and Acquisitions
17.12.5 Certifications
List not exhaustive!
18 Global Biosimulation Market – Distribution Model (Additional Insight)
18.1 Overview
18.2 Potential Distributors
18.3 Key Parameters for Distribution Partner Assessment
19 Key Opinion Leaders (KOL) Insights (Additional Insight)
20 Company Competitiveness Analysis (Additional Insight)
20.1 Very Small Companies
20.2 Small Companies
20.3 Mid-Sized Companies
20.4 Large Companies
20.5 Very Large Companies
21 Payment Methods (Additional Insight)
21.1 Government Funded
21.2 Private Insurance
21.3 Out-of-Pocket
*Additional insights provided are customisable as per client requirements.
* The coverage of the Market Landscape section depends on the data availability and may cover a minimum of 80% of the total market. The EMR team strives to make this section as comprehensive as possible.
Key Questions Answered in the Report
The market attained a value of about USD 3.5 billion in 2023 driven by the technological innovations in biosimulation software across the globe.
The market is anticipated to grow at a CAGR of 16.9% during the forecast period of 2024-2032, likely to reach a market value of USD 14.1 billion by 2032.
Growing preference for personalized medicine along with increasing investments in research and development sector are fuelling the market demand.
One of the significant trends in the market is the increased acquisition and merger initiatives by the key market players. In December 2023, Certara acquired Applied Biomath, an innovative biotechnology company, to industrialize quantitative systems pharmacology (QSP) biosimulation methods.
Based on the products and services, the market is segmented into software comprising molecular modeling and simulation software, PBPK modeling and simulation software, trial design software, toxicity prediction software, and other biosimulation software. Services include in-house services and contract services.
Based on the delivery model, the market includes a subscription model and an ownership model.
Major end users of the market include pharmaceutical and biotechnology companies, contract research organizations, academic research institutes, and others.
Applications of the market include drug discovery and drug development. Drug discovery includes pre-clinical testing and clinical trials, and drug development encompasses target identification, validation, lead identification, and optimization, among others.
The major regions of the market include North America, Europe, Asia Pacific, Latin America, Middle East, and Africa.
Key players involved in the market are Certara Inc., Dassault Systemes, Simulation Plus, Schrodinger Inc., Advanced Chemistry Development Inc., Physiomics PLC, Genedata AG, Thermo Fisher Scientific, Immunetrics, BioSimulation Consulting Inc., Yokogawa Insillico Biotechnology GmbH, and Chemical Computing Group ULC.
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