The hepatitis B vaccine market size in the 7 major markets was valued at USD 5.03 Billion in 2025, driven by the increasing incidence of hepatitis B cases across the major markets. The market is expected to grow at a CAGR of 4.80% during the forecast period of 2026-2035, with the values likely to rise to USD 8.04 Billion by 2035.
Base Year
Historical Period
Forecast Period
Compound Annual Growth Rate
4.8%
Value in USD Billion
2026-2035
*this image is indicative*
Hepatitis B is a liver infection caused by the hepatitis B virus. The infection may be long term (chronic) or short term (acute). Chronic hepatitis B can put people at the risk of death from cirrhosis and liver cancer. It can spread through fluid transfusion from an infected person and even transfer from a mother to the child. Hepatitis B vaccinations play a crucial role in minimizing the risk of this fatal disease. The vaccinations can protect against the infection for at least 20 years.
With notable advancements within the range vaccines available, the hepatitis B vaccine market value has risen significantly in the recent years. Some of the notable authorized hepatis B vaccinations include Engerix-B, a noninfectious recombinant DNA vaccine, Heplisav-B®, Recombivax HB, and Twinrix hepatitis vaccine, which is indicated for both hepatitis A and B, adding versatility to the market.
The hepatitis B vaccine market growth is likely to expediate with the on-going investigations. The U.S. CDC's initiative for Universal Hepatitis B Vaccination in Adults aged 19–59 signals a broader adoption trend. VTP-300, the hepatits B vaccination by Vaccitech is undergoing trials and has shown positive outcomes, indicating its breakthrough in upcoming years.
GSK plc's upcoming presentation at The Liver Meeting® 2023 is set to unveil insights from the B-Together phase IIb trial on bepirovirsen. It is an antisense oligonucleotide for chronic hepatitis B showcasing encouraging outcomes, especially in combination with pegylated interferon alfa. The trial evaluates the sequential regimen's efficacy in treating CHB infection, reducing hepatitis B surface antigen, and lowering virus DNA in the blood. Such developments hold a promising future for the vaccinations market in the forecast period.
"Global Hepatitis B Vaccine Market Report and Forecast 2026-2035" offers a detailed analysis of the market based on the following segments:
Market Breakup by Type
Market Breakup by Age
Market Breakup by End User
Market Breakup by Region
The World Health Organization estimates that the world population may suffer with 1.5 million new hepatitis B infections every year, as a result, the hepatitis B vaccine market demand has increased significantly. North America, particularly the United States, has dominated the market in the historical period. The market share can be accredited to the presence of key market players offering advanced vaccines. The region's well-established healthcare infrastructure and high awareness levels have further propelled market growth.
European market has also expanded with its robust healthcare system and proactive vaccination drives. The ongoing research and development activities by pharmaceutical companies, along with collaborations and partnerships among research institutions, continue to drive innovation in the region.
Going forward, Asia Pacific and Africa are poised to become pivotal centres for hepatitis B vaccine market share. These regions face a higher burden of hepatitis B infections, demanding high vaccination initiatives. Asia Pacific, being home to densely populated countries with emerging economies, is witnessing a surge in healthcare awareness and infrastructure development. The rising prevalence of hepatitis B in these regions amplifies the urgency for vaccination programs.
The key features of the market report include patent analysis, grants analysis, clinical trials analysis, funding and investment analysis, partnerships, and collaborations analysis by the leading key players. The major companies in the market are as follows:
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The market attained a value of about USD 5.03 Billion in 2025, driven by the increasing prevalence of hepatitis B cases across the 7 major markets.
The market is anticipated to grow at a CAGR of 4.80% during the forecast period of 2026-2035, likely to reach a market value of USD 8.04 Billion by 2035.
The market demand has increased with the advent of highly efficient vaccinations such as Engerix-B, Heplisav-B®, Recombivax HB, and Twinrix hepatitis vaccine.
The current market trend is marked by the ongoing investigation on vaccines for adults falling the age group of 19-59. One such example is VTP-300 by Vaccitech, which is currently in trials and displayed positive results.
Single antigen and combination are common Hepatitis B vaccine types.
They are available for pediatrics as well as adults.
Major end users include hospitals, clinics, and vaccination centres.
The major regions of the market include United States, EU-4 and the United Kingdom, Japan. EU-4 includes Germany, France, Italy, and Spain.
Key players involved in the market are Merck & Co. Inc., Sanofi S.A., GlaxoSmithKline plc., Pancea Biotech Ltd., Beijing Tiantan Biological Products Co., Ltd., VBI Vaccines Inc., Emmy Vaccine Co. Ltd., Beijing Minhai Biological Technology Co., Ltd., and Dynavax Technologies Corporation.
Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.
| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Type |
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| Breakup by Age |
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| Breakup by End User |
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| Breakup by Region |
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| Market Dynamics |
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| Competitive Landscape |
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| Companies Covered |
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