The Japan bone void fillers market was valued at USD 134.80 Million in 2025 and is expected to grow at a CAGR of 8.27%, reaching USD 298.38 Million by 2035. The market is experiencing growth due to aging population and increasing demand for spinal and orthopedic surgeries.
Base Year
Historical Period
Forecast Period
According to Yubao Lu et al. 2024, Japan’s incidence rate of traumatic spinal cord injury is increasing significantly, reaching 95.25 per million people. This elevated prevalence is driving market growth through increased need for advanced spinal and orthopedic repair solutions.
The Japan bone void fillers market is experiencing growth driven by the increasing use of bioceramic materials like biphasic calcium phosphate ceramics, advancements in minimally invasive surgical techniques, and heightened demand for regenerative treatments in orthopedic and dental procedures.
The market growth is driven is driven due to factors such as the presence of major global companies, including those specializing in orthopedic and dental biomaterials, as well as regional Japanese firms focused on innovation and regulatory compliance in bone void filler products.
Compound Annual Growth Rate
8.27%
Value in USD Million
2026-2035
*this image is indicative*
Bone void fillers are biocompatible materials used to fill bone defects or voids resulting from trauma, surgery, or disease. These fillers promote bone regeneration, provide structural support, and can be resorbable or non-resorbable, depending on clinical requirements. They are commonly used in orthopedic, spinal, and dental procedures. The market was valued at USD 134.80 Million in 2025, driven by a rising geriatric population, increasing orthopedic surgeries, and advancements in biomaterials. The demand for minimally invasive procedures and improved post-surgical outcomes is further fueling market growth. Regulatory support and innovation also contribute to the expansion of adoption across healthcare facilities.
Increasing Prevalence of Osteoporosis to Elevate the Market Growth
The increasing prevalence of osteoporosis in Japan is a critical factor driving the growth of the market. According to Yu Mori et al., 2024, more than 13 million individuals in Japan are currently affected by osteoporosis. Furthermore, the number of hip fracture incidents is projected to rise significantly from 240,000 cases in 2020 to approximately 320,000 by 2040, marking the highest forecast among Asian countries. This growing patient population, combined with the increasing demand for effective treatment options, is expected to substantially boost the adoption of bone void fillers. Consequently, these trends are anticipated to contribute to steady and sustained market expansion over the coming years.
The market is experiencing key trends such as an aging population and increased investment in regenerative biomaterials.
The market report offers a detailed analysis of the market based on the following segments:
Market Breakup by Type
Market Breakup by Form
Market Breakup by End User
Segmentation Based on Application to Witness Substantial Growth
Several types of bone void fillers are available in the market, including demineralized bone matrix, collagen matrix, calcium sulphate, tri-calcium phosphate, and others. Among these, calcium sulphate is expected to lead the market due to its enhanced biocompatibility, rapid resorption, and wide application in orthopedic surgeries. For example, Kyocera Corporation, headquartered in Kyoto, Japan, distributes ReBOSSIS, a cutting-edge biosynthetic bone scaffold composed of β-tricalcium phosphate (β-TCP), calcium carbonate, silicon, and PLGA. ReBOSSIS is noted for its exceptional handling, compression recovery, and osteoinductive capabilities, making it highly effective in bone regeneration. Such advanced biomaterials reinforce calcium sulphate-based products’ leading position in the Japanese market, driven by increasing demand for reliable bone void fillers in trauma and reconstructive surgery.
The key features of the market report comprise patent analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the market are as follows:
Hoya Technosurgical Corporation, headquartered in Tokyo, Japan, was established in 1941. The company is actively involved in the Japan bone void fillers market with its product "ReFit," a bone graft substitute composed of hydroxyapatite and type I collagen. ReFit offers flexible operability, promotes bone regeneration, and has demonstrated superior clinical efficacy in bone defect repair, supporting its growing presence in this sector.
Headquartered in Japan and established in 2011, OrthoReBirth specializes in innovative bone void fillers for orthopedic and reconstructive surgeries. Their flagship product, ReBOSSIS, a bioactive cotton-shaped artificial bone filler, has been marketed in the United States since 2015 and the Japanese market with variants like ReBOSSIS-J for maxillofacial surgery. The company actively advances bioabsorbable fiber technology in the Bone Void Fillers Market.
Stryker Corporation is a leading medical technology company specializing in orthopedics and surgical equipment is headquartered in the United States. In the bone void fillers market, Stryker offers Vikos Void Fillers, designed for spine surgery to fill osseous defects. These cancellous bone allografts, processed by LifeNet Health, support surgeons with various sizes and particle options to meet clinical needs.
Founded in 1927, Zimmer Biomet Holdings, Inc. has become one of the leading companies in the bone void fillers market. Their product, Calcigen S, is a calcium sulfate-based bone void filler engineered to harden during surgery, creating an environment that promotes bone regeneration. This resorbable and user-friendly material highlights Zimmer Biomet’s dedication to innovation in orthopedic biologics.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other key players in the market include Kyocera Corporation, Aimedic MMT Co., Ltd., Medtronic plc., DePuy Synthes (Johnson & Johnson), BONESUPPORT AB, Collagen Matrix, Inc., Orthofix Medical Inc., and NuVasive, Inc., among others.
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*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Type |
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| Breakup by Form |
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| Breakup by End User |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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