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Global Protein Expression Market Size, Trends, Forecast: By Type of Expression System: Bacterial Expression Systems, Mammalian Expression Systems, Yeast Expression Systems, Insect Expression Systems, Others; By Product Type; By Application; By Technique; By Cell Type; By End User; Regional Analysis; Supplier Landscape; 2024-2032
Global Protein Expression Market Outlook
The global protein expression market size was valued at USD 3 billion in 2023, driven by the increased protein-based research and development activities across the globe. The market is expected to grow at a CAGR of 5.40% during the forecast period of 2024-2032, with the values likely to rise from USD 3.2 billion in 2024 to USD 4.9 billion by 2032.
Global Protein Expression Market Overview
The increased impetus on therapeutic proteins in modern medicine along with the robust research and development activities is positively impacting the market landscape. To manufacture various protein-based pharmaceutical products, several expression systems have been developed. Recent advancements have made it possible to produce therapeutic proteins against cancers and infectious diseases, which is expected to boost the protein expression market demand in the forecast period.
The market is witnessing significant investments from the key market players to accommodate the growing demand for personalized medicines. In February 2024 , BioAscent, a United Kingdom-based pharmaceutical company invested in a new protein production facility to enable in-house production of proteins. A major portion of the investment was made in specialized equipment including FPLC (fast protein liquid chromatography). The facility, with a team of skilled protein scientists, will be dedicated to the expression and purification of proteins from various expression systems. Such investments will accelerate the timelines of drug discovery projects and will contribute to the protein expression market growth in the coming years.
The market is also driven by the growing demand for protein biologics and the adoption of recombinant-based protein expression. Moreover, the rise in the prevalence of chronic diseases necessitating the development of effective therapeutics is propelling the market growth.
Global Protein Expression Market Trends
| Key Trends | Description |
| Advancements in Protein Expression Technologies | The significant improvements in protein expression technologies have enabled more efficient, scalable, and cost-effective protein production, catering to the increasing demand for therapeutic proteins, vaccines, and for use in research applications. |
| Rise in Chronic Diseases | The global increase in the prevalence of chronic diseases such as cancer, diabetes, and autoimmune disorders has increased the demand for protein-based therapeutics. This trend is directly influencing the growth of the protein expression market, as proteins are involved in both the study and treatment of various conditions. |
| Expansion in the Biologics Market | The growing pipeline of biologics, including monoclonal antibodies, vaccines, and gene therapies, is driving the need for robust protein expression systems. This is because protein expression technologies are needed for the development and manufacturing of these complex biological products. |
| Growing Interest in Personalized Medicine | The need for protein expression in small-scale, patient-specific batches is pushing the market towards more flexible and efficient expression systems capable of producing a wide variety of proteins. |
Global Protein Expression Market Segmentation
Market Breakup by Type of Expression System
- Bacterial Expression Systems
- Mammalian Expression Systems
- Yeast Expression Systems
- Insect Expression Systems
- Cell-Free Expression Systems
- Algal Expression Systems
- Other Expression Systems
The market is segmented by the type of expression system into bacterial expression systems, mammalian expression systems, yeast expression systems, insect expression systems, cell-free expression systems, algal expression systems, and other expression systems. These systems are widely used in research institutes and industries to enable the production of proteins for various applications.
Market Breakup by Product Type
- Reagents
- Expression Vectors
- Competent Cells
- Instruments
- Services
By product type, the protein expression market share is divided into reagents, expression vectors, competent cells, instruments, and services. These products and services support the efficient production and manipulation of proteins.
Market Breakup by Application
- Therapeutic Proteins
- Research Applications
- Industrial Proteins
- Diagnostic Proteins
- Others
Applications of the market include therapeutic proteins, research applications, industrial proteins, diagnostic proteins, and others. The increased application of protein expression in various sectors including drug development, scientific research, and industrial processes is boosting the market size.
Market Breakup by Technique
- Ion Exchange Chromatography
- Hydrophobic Interaction Chromatography (HIC)
- Affinity Chromatography
- Size Exclusion Chromatography
- Others
Based on the technique, the protein expression market report includes ion exchange chromatography, hydrophobic interaction chromatography (HIC), affinity chromatography, size exclusion chromatography, and others. Depending on the properties of the proteins, these techniques are employed for protein purification and separation.
Market Breakup by Cell Type
- Mammalian Cells
- Bacterial Cells
- Yeast Cells
- Insect Cells
- Algal Cells
- Cell-Free Systems
The market is segmented by cell type into mammalian cells, bacterial cells, yeast cells, insect cells, algal cells, and cell-free systems. These cell types serve as host systems for protein expression for various applications in research and pharmaceutical industries, among others.
Market Breakup by End User
- Biotechnology and Pharmaceutical Companies
- Academic Research Institutes
- Contract Research Organizations (CROs)
- Others
Based on the end user, the protein expression market share includes biotechnology and pharmaceutical companies, academic research institutes, contract research organizations (CROs), and others. These end users drive demand for protein expression products and services.
Market Breakup by Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East and Africa
The market report offers deep insights into the major regional markets which include North America, Europe, Asia Pacific, Latin America, the Middle East, and Africa. North America holds a high market value due to the rapid advancement in the healthcare infrastructure. The market is also driven by the presence of premium research institutes and leading market players contributing actively to the growing market share.
Global Protein Expression Market: Competitor Landscape
The key features of the market report include patent analysis, grants analysis, funding and investment analysis, partnerships, and collaborations analysis by the leading key players. The major companies in the market are as follows:
- Thermo Fisher Scientific, Inc.
- Merck KGaA (Sigma-Aldrich Corporation)
- Agilent Technologies, Inc.
- Bio-Rad Laboratories, Inc.
- QIAGEN N.V.
- Lonza Group AG
- Genscript Biotech Corporation
- Takara Bio Inc.
- Promega Corporation
- New England Biolabs
- Oxford Expression Technologies Ltd. (OET)
- Synthetic Genomics, Inc.
- Biomatik Corporation
- Cayman Chemical Company
- Zymo Research Corporation
Kindly note that this only represents a partial list of companies, and the complete list has been provided in the report.
Key Highlights of the Report
| REPORT FEATURES | DETAILS |
| Base Year | 2023 |
| Historical Period | 2017-2023 |
| Forecast Period | 2024-2032 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
|
| Breakup by Type of Expression System |
|
| Breakup by Product Type |
|
| Breakup by Application |
|
| Breakup by Technique |
|
| Breakup by Cell Type |
|
| Breakup by End User |
|
| Breakup by Region |
|
| Market Dynamics |
|
| Supplier Landscape |
|
| Companies Covered |
|
Key Queries Solved in the Global Protein Expression Market Report
- What are the current trends driving the global protein expression market?
- Which factors are influencing the growth of protein expression technologies?
- What are the key challenges faced by stakeholders in the protein expression market?
- Which type of protein expression system is expected to dominate the market segment?
- What are the applications and end-users driving demand in the protein expression market?
- Which applications are expected to significantly impact the protein expression market demand?
- Which cell type is expected to dominate the market demand?
- Which regions are witnessing significant growth in the protein expression market?
- What are the regulatory frameworks impacting the protein expression market?
- How is technological advancement shaping the future of the protein expression market?
- How is the integration of automation and artificial intelligence influencing protein expression research and production?
- What are the emerging opportunities for players in the protein expression market?
- What are the competitive landscape and key strategies adopted by leading companies?
*At Expert Market Research, we strive to always give you current and accurate information. The numbers depicted in the description are indicative and may differ from the actual numbers in the final EMR report.
1 Preface
1.1 Objectives of the Study
1.2 Key Assumptions
1.3 Report Coverage – Key Segmentation and Scope
1.4 Research Methodology
2 Executive Summary
3 Global Protein Expression Market Overview
3.1 Global Protein Expression Market Historical Value (2017-2023)
3.2 Global Protein Expression Market Forecast Value (2024-2032)
4 Global Protein Expression Market Landscape*
4.1 Global Protein Expression: Developers Landscape
4.1.1 Analysis by Year of Establishment
4.1.2 Analysis by Company Size
4.1.3 Analysis by Region
4.2 Global Protein Expression: Product Landscape
4.2.1 Analysis by Product Type
4.2.2 Analysis by Application
5 Global Protein Expression Market Dynamics
5.1 Market Drivers and Constraints
5.2 SWOT Analysis
5.2.1 Strengths
5.2.2 Weaknesses
5.2.3 Opportunities
5.2.4 Threats
5.3 Porter’s Five Forces Model
5.3.1 Bargaining Power of Suppliers
5.3.2 Bargaining Power of Buyers
5.3.3 Threat of New Entrants
5.3.4 Threat of Substitutes
5.3.5 Degree of Rivalry
5.4 Key Demand Indicators
5.5 Key Price Indicators
5.6 Industry Events, Initiatives, and Trends
5.7 Value Chain Analysis
6 Global Protein Expression Market Segmentation (2017-2032)
6.1 Global Protein Expression Market (2017-2032) by Type of Expression System
6.1.1 Market Overview
6.1.2 Bacterial Expression Systems
6.1.3 Mammalian Expression Systems
6.1.4 Yeast Expression Systems
6.1.5 Insect Expression Systems
6.1.6 Cell-Free Expression Systems
6.1.7 Algal Expression Systems
6.1.8 Other Expression Systems
6.2 Global Protein Expression Market (2017-2032) by Product Type
6.2.1 Market Overview
6.2.2 Reagents
6.2.3 Expression Vectors
6.2.4 Competent Cells
6.2.5 Instruments
6.2.6 Services
6.3 Global Protein Expression Market (2017-2032) by Application
6.3.1 Market Overview
6.3.2 Therapeutic Proteins
6.3.3 Research Applications
6.3.4 Industrial Proteins
6.3.5 Diagnostic Proteins
6.3.6 Others
6.4 Global Protein Expression Market (2017-2032) by Technique
6.4.1 Market Overview
6.4.2 Ion Exchange Chromatography
6.4.3 Hydrophobic Interaction Chromatography (HIC)
6.4.4 Affinity Chromatography
6.4.5 Size Exclusion Chromatography
6.4.6 Others
6.5 Global Protein Expression Market (2017-2032) by Cell Type
6.5.1 Market Overview
6.5.2 Mammalian Cells
6.5.3 Bacterial Cells
6.5.4 Yeast Cells
6.5.5 Insect Cells
6.5.6 Algal Cells
6.5.7 Cell-Free Systems
6.6 Global Protein Expression Market (2017-2032) by End User
6.6.1 Market Overview
6.6.2 Biotechnology and Pharmaceutical Companies
6.6.3 Academic Research Institutes
6.6.4 Contract Research Organizations (CROs)
6.6.5 Others
6.7 Global Protein Expression Market (2017-2032) by Region
6.7.1 Market Overview
6.7.2 North America
6.7.3 Europe
6.7.4 Asia Pacific
6.7.5 Latin America
6.7.6 Middle East and Africa
7 North America Protein Expression Market (2017-2032)
7.1 North America Protein Expression Market (2017-2032) by Product Type
7.1.1 Market Overview
7.1.2 Reagents
7.1.3 Expression Vectors
7.1.4 Competent Cells
7.1.5 Instruments
7.1.6 Services
7.2 North America Protein Expression Market (2017-2032) by Application
7.2.1 Market Overview
7.2.2 Therapeutic Proteins
7.2.3 Research Applications
7.2.4 Industrial Proteins
7.2.5 Diagnostic Proteins
7.2.6 Others
7.3 North America Protein Expression Market (2017-2032) by Country
7.3.1 United States of America
7.3.2 Canada
8 Europe Protein Expression Market (2017-2032)
8.1 Europe Protein Expression Market (2017-2032) by Product Type
8.1.1 Market Overview
8.1.2 Reagents
8.1.3 Expression Vectors
8.1.4 Competent Cells
8.1.5 Instruments
8.1.6 Services
8.2 Europe Protein Expression Market (2017-2032) by Application
8.2.1 Market Overview
8.2.2 Therapeutic Proteins
8.2.3 Research Applications
8.2.4 Industrial Proteins
8.2.5 Diagnostic Proteins
8.2.6 Others
8.3 Europe Protein Expression Market (2017-2032) by Country
8.3.1 United Kingdom
8.3.2 Germany
8.3.3 France
8.3.4 Italy
8.3.5 Others
9 Asia Pacific Protein Expression Market (2017-2032)
9.1 Asia Pacific Protein Expression Market (2017-2032) by Product Type
9.1.1 Market Overview
9.1.2 Reagents
9.1.3 Expression Vectors
9.1.4 Competent Cells
9.1.5 Instruments
9.1.6 Services
9.2 Asia Pacific Protein Expression Market (2017-2032) by Application
9.2.1 Market Overview
9.2.2 Therapeutic Proteins
9.2.3 Research Applications
9.2.4 Industrial Proteins
9.2.5 Diagnostic Proteins
9.2.6 Others
9.3 Asia Pacific Protein Expression Market (2017-2032) by Country
9.3.1 China
9.3.2 Japan
9.3.3 India
9.3.4 ASEAN
9.3.5 Australia
9.3.6 Others
10 Latin America Protein Expression Market (2017-2032)
10.1 Latin America Protein Expression Market (2017-2032) by Product Type
10.1.1 Market Overview
10.1.2 Reagents
10.1.3 Expression Vectors
10.1.4 Competent Cells
10.1.5 Instruments
10.1.6 Services
10.2 Latin America Protein Expression Market (2017-2032) by Application
10.2.1 Market Overview
10.2.2 Therapeutic Proteins
10.2.3 Research Applications
10.2.4 Industrial Proteins
10.2.5 Diagnostic Proteins
10.2.6 Others
10.3 Latin America Protein Expression Market (2017-2032) by Country
10.3.1 Brazil
10.3.2 Argentina
10.3.3 Mexico
10.3.4 Others
11 Middle East and Africa Protein Expression Market (2017-2032)
11.1 Middle East and Africa Protein Expression Market (2017-2032) by Product Type
11.1.1 Market Overview
11.1.2 Reagents
11.1.3 Expression Vectors
11.1.4 Competent Cells
11.1.5 Instruments
11.1.6 Services
11.2 Middle East and Africa Protein Expression Market (2017-2032) by Application
11.2.1 Market Overview
11.2.2 Therapeutic Proteins
11.2.3 Research Applications
11.2.4 Industrial Proteins
11.2.5 Diagnostic Proteins
11.2.6 Others
11.3 Middle East and Africa Protein Expression Market (2017-2032) by Country
11.3.1 Saudi Arabia
11.3.2 United Arab Emirates
11.3.3 Nigeria
11.3.4 South Africa
11.3.5 Others
12 Regulatory Framework
12.1 Regulatory Overview
12.1.1 US FDA
12.1.2 EU EMA
12.1.3 INDIA CDSCO
12.1.4 JAPAN PMDA
12.1.5 Others
13 Patent Analysis
13.1 Analysis by Type of Patent
13.2 Analysis by Publication Year
13.3 Analysis by Issuing Authority
13.4 Analysis by Patent Age
13.5 Analysis by CPC Analysis
13.6 Analysis by Patent Valuation
13.7 Analysis by Key Players
14 Grants Analysis
14.1 Analysis by Year
14.2 Analysis by Amount Awarded
14.3 Analysis by Issuing Authority
14.4 Analysis by Grant Application
14.5 Analysis by Funding Institute
14.6 Analysis by Departments
14.7 Analysis by Recipient Organization
15 Funding and Investment Analysis
15.1 Analysis by Funding Instances
15.2 Analysis by Type of Funding
15.3 Analysis by Funding Amount
15.4 Analysis by Leading Players
15.5 Analysis by Leading Investors
15.6 Analysis by Geography
16 Partnership and Collaborations Analysis
16.1 Analysis by Partnership Instances
16.2 Analysis by Type of Partnership
16.3 Analysis by Leading Players
16.4 Analysis by Geography
17 Supplier Landscape
17.1 Thermo Fisher Scientific, Inc.
17.1.1 Financial Analysis
17.1.2 Product Portfolio
17.1.3 Demographic Reach and Achievements
17.1.4 Mergers and Acquisitions
17.1.5 Certifications
17.2 Merck KGaA (Sigma-Aldrich Corporation)
17.2.1 Financial Analysis
17.2.2 Product Portfolio
17.2.3 Demographic Reach and Achievements
17.2.4 Mergers and Acquisitions
17.2.5 Certifications
17.3 Agilent Technologies, Inc.
17.3.1 Financial Analysis
17.3.2 Product Portfolio
17.3.3 Demographic Reach and Achievements
17.3.4 Mergers and Acquisitions
17.3.5 Certifications
17.4 Bio-Rad Laboratories, Inc.
17.4.1 Financial Analysis
17.4.2 Product Portfolio
17.4.3 Demographic Reach and Achievements
17.4.4 Mergers and Acquisitions
17.4.5 Certifications
17.5 QIAGEN N.V.
17.5.1 Financial Analysis
17.5.2 Product Portfolio
17.5.3 Demographic Reach and Achievements
17.5.4 Mergers and Acquisitions
17.5.5 Certifications
17.6 Lonza Group AG
17.6.1 Financial Analysis
17.6.2 Product Portfolio
17.6.3 Demographic Reach and Achievements
17.6.4 Mergers and Acquisitions
17.6.5 Certifications
17.7 Genscript Biotech Corporation
17.7.1 Financial Analysis
17.7.2 Product Portfolio
17.7.3 Demographic Reach and Achievements
17.7.4 Mergers and Acquisitions
17.7.5 Certifications
17.8 Takara Bio Inc.
17.8.1 Financial Analysis
17.8.2 Product Portfolio
17.8.3 Demographic Reach and Achievements
17.8.4 Mergers and Acquisitions
17.8.5 Certifications
17.9 Promega Corporation
17.9.1 Financial Analysis
17.9.2 Product Portfolio
17.9.3 Demographic Reach and Achievements
17.9.4 Mergers and Acquisitions
17.9.5 Certifications
17.10 New England Biolabs
17.10.1 Financial Analysis
17.10.2 Product Portfolio
17.10.3 Demographic Reach and Achievements
17.10.4 Mergers and Acquisitions
17.10.5 Certifications
17.11 Oxford Expression Technologies Ltd. (OET)
17.11.1 Financial Analysis
17.11.2 Product Portfolio
17.11.3 Demographic Reach and Achievements
17.11.4 Mergers and Acquisitions
17.11.5 Certifications
17.12 Synthetic Genomics, Inc.
17.12.1 Financial Analysis
17.12.2 Product Portfolio
17.12.3 Demographic Reach and Achievements
17.12.4 Mergers and Acquisitions
17.12.5 Certifications
17.13 Biomatik Corporation
17.13.1 Financial Analysis
17.13.2 Product Portfolio
17.13.3 Demographic Reach and Achievements
17.13.4 Mergers and Acquisitions
17.13.5 Certifications
17.14 Cayman Chemical Company
17.14.1 Financial Analysis
17.14.2 Product Portfolio
17.14.3 Demographic Reach and Achievements
17.14.4 Mergers and Acquisitions
17.14.5 Certifications
17.15 Zymo Research Corporation
17.15.1 Financial Analysis
17.15.2 Product Portfolio
17.15.3 Demographic Reach and Achievements
17.15.4 Mergers and Acquisitions
17.15.5 Certifications
List not exhaustive
18 Global Protein Expression Market – Distribution Model (Additional Insight)
18.1 Overview
18.2 Potential Distributors
18.3 Key Parameters for Distribution Partner Assessment
19 Key Opinion Leaders (KOL) Insights (Additional Insight)
20 Company Competitiveness Analysis (Additional Insight)
20.1 Very Small Companies
20.2 Small Companies
20.3 Mid-Sized Companies
20.4 Large Companies
20.5 Very Large Companies
21 Payment Methods (Additional Insight)
21.1 Government Funded
21.2 Private Insurance
21.3 Out-of-Pocket
*Additional insights provided are customisable as per client requirements.
* The coverage of the Market Landscape section depends on the data availability and may cover a minimum of 80% of the total market. The EMR team strives to make this section as comprehensive as possible.
Key Questions Answered in the Report
The market attained a value of about USD 3 billion in 2023 driven by the increased protein-based research and development activities across the globe.
The market is anticipated to grow at a CAGR of 5.40% during the forecast period of 2024-2032, likely to reach a market value of USD 4.9 billion by 2032.
The growing preference for personalized medicines and the increased healthcare expenditure are fuelling the demand for the market.
One of the significant trends in the market is the rising investments from the key market players. In February 2024 , BioAscent, invested in a new protein production facility to facilitate in-house production of proteins. The facility, with a team of skilled protein scientists, will be dedicated to the expression and purification of proteins from various expression systems.
The market is segmented by the type of expression system into bacterial expression systems, mammalian expression systems, yeast expression systems, insect expression systems, cell-free expression systems, algal expression systems, among other expression systems.
Based on the technique, the market includes ion exchange chromatography, hydrophobic interaction chromatography (HIC), affinity chromatography, size exclusion chromatography, and others.
Based on the product type, the market is segmented into reagents, expression vectors, competent cells, instruments, and services.
The market is segmented by cell type into mammalian cells, bacterial cells, yeast cells, insect cells, algal cells, and cell-free systems.
Major end users of the market include biotechnology and pharmaceutical companies, academic research institutes, contract research organizations (CROs), and others.
Applications of the market include therapeutic proteins, research applications, industrial proteins, diagnostic proteins, and others.
The major regions of the market include North America, Europe, Asia Pacific, Latin America, Middle East, and Africa.
Key players involved in the market are Thermo Fisher Scientific, Inc., Merck KGaA (Sigma-Aldrich Corporation), Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., QIAGEN N.V., Lonza Group AG, Genscript Biotech Corporation, Takara Bio Inc., Promega Corporation, New England Biolabs, Oxford Expression Technologies Ltd. (OET), Synthetic Genomics, Inc., Biomatik Corporation, Cayman Chemical Company, and Zymo Research Corporation.
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