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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare autoimmune neurological disorder marked by progressive damage to the myelin sheath of peripheral nerves, leading to weakness, sensory loss, and impaired motor function. According to Yusuf A. Rajabally et al. (2024), the global prevalence is about 3 per 100,000 people, varying with diagnostic criteria. Current therapies include corticosteroids, intravenous immunoglobulin (IVIg), and plasma exchange, with emerging monoclonal antibody and gene-based treatments in development. According to the chronic inflammatory demyelinating polyradiculoneuropathy pipeline analysis by Expert Market Research, increasing research investments, novel biologics, and improved diagnostics are expected to drive significant pipeline growth and better outcomes in the coming years.
Major companies involved in the chronic inflammatory demyelinating polyradiculoneuropathy pipeline analysis include Takeda, Immunovant Sciences GmbH, and others.
Leading drugs currently in the pipeline include DNTH103, TAK-881 + HYQVIA, IMVT-1402, and others.
The pipeline is set to expand with increased focus on novel biologics, targeted immunotherapies, and monoclonal antibodies, driven by rising prevalence, unmet clinical needs, and advanced clinical trial developments.
The Chronic Inflammatory Demyelinating Polyradiculoneuropathy Pipeline Analysis Report by Expert Market Research gives comprehensive insights into chronic inflammatory demyelinating polyradiculoneuropathy therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for chronic inflammatory demyelinating polyradiculoneuropathy. The chronic inflammatory demyelinating polyradiculoneuropathy report assessment includes the analysis of over 100 pipeline drugs and 50+ companies. The chronic inflammatory demyelinating polyradiculoneuropathy pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with chronic inflammatory demyelinating polyradiculoneuropathy treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to chronic inflammatory demyelinating polyradiculoneuropath.

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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare, progressive autoimmune disorder affecting the peripheral nervous system. It occurs when the immune system mistakenly attacks the myelin sheath of nerves, causing weakness, sensory loss, fatigue, and impaired mobility, often worsening over time and significantly reducing quality of life.
Chronic inflammatory demyelinating polyradiculoneuropathy treatments focus on reducing immune-mediated nerve damage using corticosteroids, intravenous immunoglobulin, plasma exchange, and newly approved targeted therapies to improve muscle strength and functional independence. In June 2024, argenx announced FDA approval of VYVGART Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) as a once-weekly subcutaneous injection for CIDP, marking the first neonatal Fc receptor blocker approved, offering patients a novel, precision-based treatment option in the CIDP drug pipeline.
Epidemiological data highlight the significance of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in guiding drug development. According to Rajabally YA et al., 2024, the global prevalence of CIDP is approximately 3 per 100,000, with an incidence of less than 1 per 100,000 annually. As per Cleveland Clinic, the United States records 0.8 to 8.9 new cases per 100,000 people each year. Rajabally et al., 2025, reported prevalence of 6.18 per 100,000 in Birmingham, UK, with lower rates in Asian (Indian/Pakistani/Bangladeshi) populations at 2.64 per 100,000 versus 10.15 per 100,000 in white subjects. Incidence was also lower in Asians (0.24 vs. 0.86 per 100,000 per year).
This section of the report covers the analysis of chronic inflammatory demyelinating polyradiculoneuropathy drug candidates based on several segmentations, including:
By Phase
The pipeline assessment report covers 50+ drug analyses based on phase:
By Drug Class
The chronic inflammatory demyelinating polyradiculoneuropathy pipeline analysis report covers 50+ drug analyses based on drug classes:
By Route of Administration
The pipeline assessment report covers 50+ drug analyses based on the route of administration:
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis, phase III, with 38%, covers a major share of the total chronic inflammatory demyelinating polyradiculoneuropathy clinical trials, indicating advanced development and strong potential for near-term approvals. Phase II contributes 29%, supporting robust clinical progression. Early phase I and phase IV each account for 12%, while phase I represents 9%, collectively reflecting a balanced and promising pipeline poised to drive market growth and innovation.
The drug molecule categories covered under the chronic inflammatory demyelinating polyradiculoneuropathy pipeline analysis include small molecules, monoclonal antibodies, and immunoglobulin products. The chronic inflammatory demyelinating polyradiculoneuropathy report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for chronic inflammatory demyelinating polyradiculoneuropathy. Immune-based therapies are being explored for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy. For example, TAK-411, a hypersialylated immunoglobulin G, is under investigation in a phase 2 trial to assess its safety, efficacy, and tolerability. It is designed to reduce inflammation and improve functional ability, targeting key symptoms such as muscle weakness, impaired sensation, and fatigue in affected patients.
The EMR report for the chronic inflammatory demyelinating polyradiculoneuropathy pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed chronic inflammatory demyelinating polyradiculoneuropathy therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in chronic inflammatory demyelinating polyradiculoneuropathy clinical trials:
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for chronic inflammatory demyelinating polyradiculoneuropathy. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of chronic inflammatory demyelinating polyradiculoneuropathy drug candidates.
DNTH103, sponsored by Dianthus Therapeutics, is a clinical-stage monoclonal antibody designed to selectively inhibit the activated form of the C1s protein, targeting the classical complement pathway implicated in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). This Phase III study is demonstrating the efficacy and safety of DNTH103 compared to placebo in adults with CIDP. Administered via convenient subcutaneous injection as infrequently as once every two weeks, DNTH103 preserves immune activity in the lectin and alternative pathways while reducing complement-mediated nerve damage. The study includes an open-label period, a randomized double-blind treatment period, an optional extension, and safety follow-up, aiming to establish DNTH103 as a best-in-class therapy for autoimmune neuropathies.
TAK-881, sponsored by Takeda, is an investigational subcutaneous immunoglobulin therapy being studied for adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). This Phase III trial aims to evaluate the pharmacokinetic comparability between TAK-881 and the established therapy HYQVIA. The study is examining how TAK-881 performs in maintaining immune support in participants previously receiving intravenous or subcutaneous immunoglobulin, with treatment administered every 3–4 weeks in the clinic and later allowing home infusions. TAK-881 works by supplementing the patient’s immune system with necessary antibodies, supporting nerve protection, and reducing demyelination.
IMVT-1402 is being developed by Immunovant Sciences GmbH for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP). This Phase IIb, multi-center, randomized, double-blind, placebo-controlled study is examining the efficacy and safety of IMVT-1402 in adult participants with active CIDP. IMVT-1402 is a subcutaneous injection administered once weekly, designed to modulate the immune system and reduce autoimmune-mediated nerve damage. The study is assessing whether the drug can prevent disease relapse and improve physical function, including muscle strength, grip strength, and overall disability, using measures such as aINCAT, I-RODS, and MRC-SS.
*Please note that this is only a partial list; the complete list of drugs will be available in the full report.*
The Chronic Inflammatory Demyelinating Polyradiculoneuropathy Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for chronic inflammatory demyelinating polyradiculoneuropathy. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into chronic inflammatory demyelinating polyradiculoneuropathy collaborations, regulatory environments, and potential growth opportunities.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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