Consumer Insights
Uncover trends and behaviors shaping consumer choices today
Procurement Insights
Optimize your sourcing strategy with key market data
Industry Stats
Stay ahead with the latest trends and market analysis.
Explore Our Diverse Range Of Offerings
From detailed reports to experts services offered in 15+
Industry Domains
Add 2 More Reports For 20% off
Amitriptyline Hydrochloride Prices, Demand and Supply Overview
Amitriptyline Hydrochloride prices in Germany, the highest-cost reporting region, rose 6.1% in H1 2026, climbing from USD 31.2/KG in Q1 to USD 33.1/KG by Q2 as recovering neuropathic pain, major depressive disorder, and migraine prophylaxis formulation procurement and firmer dibenzocycloheptadiene synthesis intermediate costs reversed the brief Q3 2025 market dip. Globally, the average rose from USD 22.44/KG in Q1 to USD 23.79/KG in Q2, a 6.0% gain. For H2 2026, a global average of USD 23.9-26.8/KG is expected, with continued firming on Middle East supply disruptions and growing antidepressant, neuropathic pain, and migraine prophylaxis sector demand globally.
Amitriptyline Hydrochloride is the hydrochloride salt of amitriptyline, a tertiary amine tricyclic antidepressant produced by multi-step synthesis from dibenz[b,e]oxepin-11(6H)-one through Grignard reaction with dimethylaminopropylmagnesium chloride, dehydration, and salt formation with hydrochloric acid to yield the dibenzocycloheptadiene-based amitriptyline hydrochloride. The compound inhibits presynaptic reuptake transporters for both serotonin and norepinephrine with higher relative affinity for the serotonin transporter, while also exerting significant antihistaminergic, anticholinergic, and alpha-adrenoceptor blocking activity contributing to the sedative and analgesic properties that distinguish it from selective serotonin reuptake inhibitors and drive its continued widespread use in pain indications. The largest pull comes from neuropathic pain management at low therapeutic doses, where amitriptyline is a recommended first-line treatment for diabetic peripheral neuropathy, post-herpetic neuralgia, and fibromyalgia across published clinical guidelines. Major depressive disorder treatment, migraine and chronic tension headache prophylaxis, and insomnia management at sub-antidepressant doses add significant further demand. Irritable bowel syndrome and overactive bladder formulation add consistent volumes. Dibenzocycloheptadiene synthesis intermediate costs, neuropathic pain and antidepressant prescription volumes, and regional API production capacity all feed into the price.
Amitriptyline Hydrochloride Price Forecast for 2026
The balance of supply and demand for Amitriptyline Hydrochloride through H2 2026 leans moderately firm. Synthesis intermediate costs firmed from Middle East chemical supply disruptions. Neuropathic pain management, antidepressant, and migraine prophylaxis demand are growing with expanding chronic pain and mental health treatment access globally.
The main upside risk is synthesis intermediate cost increases alongside accelerating neuropathic pain management guideline adoption. The main downside risk is continued Chinese and Indian API surplus and SSRI prescribing preference maintaining price pressure below forecast.
| Region | Price Forecast (USD/KG) | Key Driver |
| Global Average | 23.9 - 26.8 | Synthesis cost firming and neuropathic pain/antidepressant demand |
| United States | 25.3 - 28.2 | Steady neuropathic pain and antidepressant demand holds firm |
| China | 17.5 - 20.4 | Large API capacity keeps it the most affordable |
| Germany | 31.4 - 34.3 | High synthesis and energy costs keep it the most expensive |
| India | 24.2 - 27.1 | Growing pain management and export demand holds a firm middle |
For the Quarter Ending June 2026
Amitriptyline Hydrochloride Prices Q2 2026:
- United States: USD 26.9/KG
- China: USD 18.6/KG
- Germany: USD 33.1/KG
- India: USD 25.6/KG
Amitriptyline Hydrochloride Prices in the United States
US Amitriptyline Hydrochloride prices averaged USD 26.9/KG in Q2 2026, up 5.9% from USD 25.4/KG in Q1 2026. Firmer synthesis intermediate costs and recovering neuropathic pain and antidepressant formulation procurement drove consistent buying through the quarter.
Why did the price of Amitriptyline Hydrochloride change in Q2 2026 in the United States?
Firmer dibenzocycloheptadiene synthesis intermediate costs raised the API production floor. Neuropathic pain, major depressive disorder, migraine prophylaxis, and insomnia formulation procurement lifted buying. Chronic pain guideline-driven demand provided additional support near USD 26.9/KG.
Amitriptyline Hydrochloride Prices in China
Chinese Amitriptyline Hydrochloride prices averaged USD 18.6/KG in Q2 2026, up 6.3% from USD 17.5/KG in Q1 2026, the lowest among the tracked markets. Spring neuropathic pain and antidepressant export and domestic procurement lifted buying. Firmer domestic synthesis costs raised the floor despite domestic API capacity.
Why did the price of Amitriptyline Hydrochloride change in Q2 2026 in China?
Spring neuropathic pain and antidepressant export and domestic procurement lifted buying. Firmer domestic synthesis intermediate costs raised the production floor. Large domestic API capacity kept China the most affordable source.
Amitriptyline Hydrochloride Prices in Germany
German Amitriptyline Hydrochloride prices averaged USD 33.1/KG in Q2 2026, up 6.1% from USD 31.2/KG in Q1 2026, the highest among the tracked markets. Higher synthesis intermediate and energy costs elevated European production economics. Recovering neuropathic pain and antidepressant demand maintained buying.
Why did the price of Amitriptyline Hydrochloride change in Q2 2026 in Germany?
Higher synthesis intermediate and energy costs elevated European API production economics. Middle East supply disruptions added cost premiums. Recovering neuropathic pain, antidepressant, and migraine prophylaxis procurement maintained buying near USD 33.1/KG.
Amitriptyline Hydrochloride Prices in India
Indian Amitriptyline Hydrochloride prices averaged USD 25.6/KG in Q2 2026, up 6.2% from USD 24.1/KG in Q1 2026. Growing neuropathic pain, antidepressant, and export demand supported buying. Firmer synthesis import costs raised the production floor.
Why did the price of Amitriptyline Hydrochloride change in Q2 2026 in India?
Growing neuropathic pain and antidepressant export and domestic procurement lifted buying. Firmer synthesis import costs raised the production floor. Migraine prophylaxis and chronic pain export demand provided additional support near USD 25.6/KG.
For the Quarter Ending March 2026
Amitriptyline Hydrochloride Prices Q1 2026:
- United States: USD 25.4/KG
- China: USD 17.5/KG
- Germany: USD 31.2/KG
- India: USD 24.1/KG
Amitriptyline Hydrochloride Prices in the United States
US prices averaged USD 25.4/KG in Q1 2026, recovering about 2.0% from Q4 2025. Recovering neuropathic pain and antidepressant demand and firming synthesis costs held the market near USD 25.4/KG.
Why did the price of Amitriptyline Hydrochloride change in Q1 2026 in the United States?
Recovering neuropathic pain and antidepressant procurement maintained buying. Firming synthesis intermediate costs raised the production floor. The market recovered to USD 25.4/KG from the Q3 2025 level.
Amitriptyline Hydrochloride Prices in China
Chinese prices averaged USD 17.5/KG in Q1 2026, recovering about 1.7% from Q4 2025. Post-Lunar New Year neuropathic pain and antidepressant restocking held the market near USD 17.5/KG.
Why did the price of Amitriptyline Hydrochloride change in Q1 2026 in China?
Post-Lunar New Year neuropathic pain and antidepressant restocking lifted buying. Firming domestic synthesis costs raised the floor. The market recovered to USD 17.5/KG from the Q3 2025 level.
Amitriptyline Hydrochloride Prices in Germany
German prices averaged USD 31.2/KG in Q1 2026, recovering about 2.0% from Q4 2025. Recovering neuropathic pain and antidepressant demand and firming synthesis and energy costs held the market near USD 31.2/KG.
Why did the price of Amitriptyline Hydrochloride change in Q1 2026 in Germany?
Recovering neuropathic pain, antidepressant, and migraine procurement maintained buying. Firming synthesis and energy costs raised the production floor. The market recovered to USD 31.2/KG from the Q3 2025 level.
Amitriptyline Hydrochloride Prices in India
Indian prices averaged USD 24.1/KG in Q1 2026, recovering about 2.1% from Q4 2025. Growing neuropathic pain and export demand and firmer synthesis costs held the market near USD 24.1/KG.
Why did the price of Amitriptyline Hydrochloride change in Q1 2026 in India?
Growing neuropathic pain and antidepressant procurement maintained buying. Firming synthesis import costs raised the floor. The market recovered to USD 24.1/KG from the Q3 2025 level.
Quarterly Amitriptyline Hydrochloride Price Trends
Global Amitriptyline Hydrochloride prices dipped in Q3 2025 on synthesis cost softening before recovering through Q4 2025, Q1 2026, and Q2 2026. The average eased from USD 22.0/KG in Q2 2025 to USD 21.56/KG in Q3, then firmed to USD 22.00/KG in Q4, USD 22.44/KG in Q1 2026, and USD 23.79/KG in Q2 2026, a net gain of about 8.1% over the window. Synthesis intermediate cost cycles and neuropathic pain, antidepressant, and migraine procurement drove the recovery pattern.
| Quarter | Price (USD/KG) | QoQ Change | Direction |
| Q2 2026 | 23.79 | +6.0% | ↑ Rising |
| Q1 2026 | 22.44 | +2.0% | ↑ Rising |
| Q4 2025 | 22.00 | +2.0% | ↑ Rising |
| Q3 2025 | 21.56 | -2.0% | ↓ Falling |
| Q2 2025 | 22.0 | - | - Stable |
| Q3 2026 | In Progress | - | - In Progress |
What was Amitriptyline Hydrochloride Price in 2025?
Amitriptyline Hydrochloride prices declined modestly in Q3 2025 before recovering through Q4. The global average opened near USD 22.5/KG in Q1 2025 and closed at USD 22.00/KG in Q4, a marginal full-year decline of about 2.2%. Synthesis cost softening and stable prescription volumes maintained stable to slightly softer conditions through the year.
Amitriptyline Hydrochloride Prices in the United States in 2025
US prices fell from about USD 25.4/KG in Q1 2025 to USD 24.9/KG by Q4, a decline of 2.0%. Soft synthesis costs maintained the modest downward trend before H1 2026 recovery.
Amitriptyline Hydrochloride Prices in China in 2025
Chinese prices fell from roughly USD 17.6/KG in Q1 2025 to USD 17.2/KG by Q4, a decline of 2.3%. Domestic API capacity and soft synthesis costs maintained the lowest level.
Amitriptyline Hydrochloride Prices in Germany in 2025
German prices fell from about USD 31.2/KG in Q1 2025 to USD 30.6/KG by Q4, a decline of 1.9%. Soft synthesis costs maintained moderate downward pressure through the year.
Amitriptyline Hydrochloride Prices in India in 2025
Indian prices fell from roughly USD 24.1/KG in Q1 2025 to USD 23.6/KG by Q4, a decline of 2.1%. Soft synthesis import costs maintained downward pressure through the year.
How We Can Help
Expert Market Research: Your Source for Real-Time Amitriptyline Hydrochloride Price Intelligence
Expert Market Research tracks Amitriptyline Hydrochloride prices continuously across every major producing and consuming region. The team traces causation through dibenzocycloheptadiene synthesis intermediate economics, neuropathic pain and antidepressant prescription cycles, and regional API production capacity. Contact Expert Market Research today for Amitriptyline Hydrochloride pricing data, bespoke market analysis, and strategic advisory.
Pricing Plans
Upto 15% Off
USD
-
$799 $699
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
Key Questions Answered in the Report
Neuropathic pain management at low therapeutic doses as a first-line treatment for diabetic peripheral neuropathy, post-herpetic neuralgia, and fibromyalgia per published clinical guidelines takes the largest share of modern prescribing. Major depressive disorder treatment, migraine and chronic tension headache prophylaxis, insomnia management, irritable bowel syndrome, and overactive bladder also consume significant volumes.
The Q2 2026 average was USD 26.9/KG in the United States, USD 18.6/KG in China, USD 33.1/KG in Germany, and USD 25.6/KG in India. Germany remains the highest-priced market.
The global average rose from USD 22.44/KG in Q1 to about USD 23.79/KG in Q2, a gain of around 6.0%. Recovering neuropathic pain and antidepressant demand and firmer synthesis costs drove the H1 firming from the Q3 2025 level.
Dibenzocycloheptadiene synthesis intermediate cost softening reduced the API production floor. Seasonal prescription moderation reduced buying urgency before the Q4 2025 and H1 2026 recovery.
The global average is expected in the USD 23.9 to 26.8/KG range for H2 2026, with continued firming as synthesis costs stay elevated and neuropathic pain, antidepressant, and migraine prophylaxis demand grows globally.
Germany sits highest on synthesis and energy costs, the United States and India hold a firm middle on neuropathic pain and antidepressant demand, and China prices lowest on domestic capacity.
This report is updated monthly. For real-time pricing intelligence, contact the Expert Market Research team directly.
Prices respond mainly to dibenzocycloheptadiene synthesis intermediate costs, neuropathic pain and antidepressant prescribing cycles, and chronic pain guideline adoption. Synthesis precursor prices and neuropathic pain prescribing data are key signals.
China and India hold the largest amitriptyline API synthesis capacity. Any synthesis intermediate cost shift ripples across markets within one to two quarters.
Buyers can use quarterly trends and forecasts to time neuropathic pain and antidepressant formulation contracts around synthesis cost cycles, build cover when intermediate signals tighten, and monitor prescribing volumes as the primary demand signal.
One Year Subscription
One Year Subscription
USD 799
USD 699
tax inclusive*
- Report in Excel Format
- 3 Months Price Forecast
- Historical Prices for the Past 3 Years
-
Summary Of Factors Influencing Prices
- Current Price Overview
- 3-Month Price Forecast
- Historical Price Summary
*Please note that the prices mentioned below are starting prices for each bundle type. Kindly contact our team for further details.*
Bundle Type
Flash Bundle
20% OFF
Number of Reports: 3
Small Business Bundle
25% OFF
Number of Reports: 5
Growth Bundle
30% OFF
Number of Reports: 8
Enterprise Bundle
35% OFF
Number of Reports: 10
Overview
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
*Please note that the prices mentioned below are starting prices for each bundle type. Kindly contact our team for further details.*
Flash Bundle
Number of Reports: 3
20%
tax inclusive*
- 3 Reports Included
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
Small Business Bundle
Number of Reports: 5
25%
tax inclusive*
- 5 Reports Included
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
Growth Bundle
Number of Reports: 8
30%
tax inclusive*
- 8 Reports Included
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
Enterprise Bundle
Number of Reports: 10
35%
tax inclusive*
- 10 Reports Included
- Historical Price Trends
- Current Market Pricing
- 3-Month Price Forecast
- Grade / Specification-wise Pricing
- Pricing Data in Excel Format
- Pricing Summary
- Monthly Price Updates
- Regional Price Benchmarking
- Price Drivers & Market Influencing Factors
- Analyst Support for Pricing Insights
How To Order
Select License Type
Choose the right license for your needs and access rights.
Click on ‘Buy Now’
Add the report to your cart with one click and proceed to register.
Select Mode of Payment
Choose a payment option for a secure checkout. You will be redirected accordingly.
Strategic Solutions for Informed Decision-Making
Gain insights to stay ahead and seize opportunities.
Get insights & trends for a competitive edge.
Track prices with detailed trend reports.
Analyse trade data for supply chain insights.
Leverage cost reports for smart savings
Enhance supply chain with partnerships.
Connect For More Information
Our expert team of analysts will offer full support and resolve any queries regarding the report, before and after the purchase.
Our expert team of analysts will offer full support and resolve any queries regarding the report, before and after the purchase.
We employ meticulous research methods, blending advanced analytics and expert insights to deliver accurate, actionable industry intelligence, staying ahead of competitors.
Our skilled analysts offer unparalleled competitive advantage with detailed insights on current and emerging markets, ensuring your strategic edge.
We offer an in-depth yet simplified presentation of industry insights and analysis to meet your specific requirements effectively.