Trazodone Hydrochloride Price Trend and Forecast 2026-2027

Trazodone Hydrochloride prices in Germany, the highest-cost reporting region, rose 6.0% in H1 2026, climbing from USD 48.5/KG in Q1 to USD 51.4/KG by Q2 as recovering major depressive disorder, insomnia, and anxiety treatment formulation procurement and firmer triazolopyridine synthesis intermediate costs reversed the brief Q3 2025 market dip. Globally, the average rose from USD 34.67/KG in Q1 to USD 36.75/KG in Q2, a 6.0% gain. For H2 2026, a global average of USD 37.10-41.60/KG is expected, with continued firming on Middle East supply disruptions and growing antidepressant and insomnia treatment sector demand globally.

Trazodone Hydrochloride is a triazolopyridine serotonin antagonist and reuptake inhibitor antidepressant produced by multi-step synthesis from triazolopyridine and chlorophenylpiperazine building blocks through N-alkylation coupling and salt formation steps to yield the 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one monohydrochloride active pharmaceutical ingredient. The compound acts as a serotonin antagonist and reuptake inhibitor, blocking post-synaptic 5-HT2A receptors while inhibiting presynaptic serotonin reuptake transporter activity, and also exerts sedative effects through histamine H1 receptor antagonism and alpha-1 adrenergic blockade at lower plasma concentrations than those required for antidepressant efficacy. The largest pull comes from off-label insomnia treatment, where trazodone is the most widely prescribed non-benzodiazepine and non-Z-drug pharmacotherapy for short-term and chronic insomnia across outpatient primary care and psychiatry settings globally, providing sleep induction and sleep maintenance benefits at low doses without the dependency risk of hypnotic agents. FDA-approved major depressive disorder treatment at antidepressant doses adds significant prescription demand. Anxiety disorder, post-traumatic stress disorder, and substance use disorder sleep disruption management add consistent demand. Triazolopyridine synthesis intermediate costs, antidepressant and insomnia prescription volumes, and regional API capacity all feed into the price.

Trazodone Hydrochloride Price Forecast for 2026

The balance of supply and demand for Trazodone Hydrochloride through H2 2026 leans moderately firm. Triazolopyridine and chlorophenylpiperazine synthesis intermediate costs firmed from Middle East supply disruptions. Insomnia treatment prescribing, antidepressant access expansion, and growing awareness of non-benzodiazepine sleep pharmacotherapy are supporting demand globally.

The main upside risk is synthesis intermediate cost increases alongside accelerating insomnia and antidepressant treatment access programme procurement. The main downside risk is Chinese API surplus and generic competition maintaining price pressure below the forecast range.

For the Quarter Ending June 2026

Trazodone Hydrochloride Prices Q2 2026:

• United States: USD 41.9/KG
• China: USD 28.8/KG
• Germany: USD 51.4/KG
• India: USD 39.6/KG

Trazodone Hydrochloride Prices in the United States

US Trazodone Hydrochloride prices averaged USD 41.9/KG in Q2 2026, up 6.1% from USD 39.5/KG in Q1 2026. Firmer synthesis intermediate costs and recovering insomnia and antidepressant procurement drove consistent buying through the quarter.

Why did the price of Trazodone Hydrochloride change in Q2 2026 in the United States?

Firmer triazolopyridine synthesis intermediate costs raised the API production floor. Insomnia treatment, major depressive disorder, and anxiety management formulation procurement lifted buying. Post-traumatic stress disorder sleep management demand provided additional support near USD 41.9/KG.

Trazodone Hydrochloride Prices in China

Chinese Trazodone Hydrochloride prices averaged USD 28.8/KG in Q2 2026, up 5.9% from USD 27.2/KG in Q1 2026, the lowest among the tracked markets. Spring insomnia and antidepressant export and domestic procurement lifted buying. Firmer domestic synthesis costs raised the floor despite domestic API capacity.

Why did the price of Trazodone Hydrochloride change in Q2 2026 in China?

Spring insomnia and antidepressant export and domestic procurement lifted buying. Firmer domestic triazolopyridine synthesis intermediate costs raised the production floor. Domestic API capacity kept China the most affordable source.

Trazodone Hydrochloride Prices in Germany

German Trazodone Hydrochloride prices averaged USD 51.4/KG in Q2 2026, up 6.0% from USD 48.5/KG in Q1 2026, the highest among the tracked markets. Higher synthesis intermediate and energy costs elevated European API production economics. Recovering insomnia, antidepressant, and anxiety treatment demand maintained buying.

Why did the price of Trazodone Hydrochloride change in Q2 2026 in Germany?

Higher triazolopyridine synthesis intermediate and energy costs elevated European API economics. Middle East supply disruptions added cost premiums to synthesis substrate chains. Recovering insomnia, major depressive disorder, and anxiety treatment procurement maintained buying near USD 51.4/KG.

Trazodone Hydrochloride Prices in India

Indian Trazodone Hydrochloride prices averaged USD 39.6/KG in Q2 2026, up 5.9% from USD 37.4/KG in Q1 2026. Growing insomnia and antidepressant export and domestic demand supported buying. Firmer synthesis import costs raised the production floor.

Why did the price of Trazodone Hydrochloride change in Q2 2026 in India?

Growing insomnia and major depressive disorder export and domestic procurement lifted buying. Firmer synthesis import costs raised the production floor. Anxiety and PTSD sleep management export demand provided additional support near USD 39.6/KG.

For the Quarter Ending March 2026

Trazodone Hydrochloride Prices Q1 2026:

• United States: USD 39.5/KG
• China: USD 27.2/KG
• Germany: USD 48.5/KG
• India: USD 37.4/KG

Trazodone Hydrochloride Prices in the United States

US prices averaged USD 39.5/KG in Q1 2026, recovering about 2.1% from Q4 2025. Recovering insomnia and antidepressant demand and firming synthesis costs held the market near USD 39.5/KG.

Why did the price of Trazodone Hydrochloride change in Q1 2026 in the United States?

Recovering insomnia treatment and antidepressant procurement maintained buying. Firming synthesis intermediate costs raised the production floor. The market recovered to USD 39.5/KG from the Q3 2025 level.

Trazodone Hydrochloride Prices in China

Chinese prices averaged USD 27.2/KG in Q1 2026, recovering about 1.9% from Q4 2025. Post-Lunar New Year insomnia and antidepressant restocking and firming synthesis costs held the market near USD 27.2/KG.

Why did the price of Trazodone Hydrochloride change in Q1 2026 in China?

Post-Lunar New Year insomnia and antidepressant restocking lifted buying. Firming domestic synthesis intermediate costs raised the floor. The market recovered to USD 27.2/KG from the Q3 2025 level.

Trazodone Hydrochloride Prices in Germany

German prices averaged USD 48.5/KG in Q1 2026, recovering about 2.1% from Q4 2025. Recovering insomnia and antidepressant demand and firming synthesis and energy costs held the market near USD 48.5/KG.

Why did the price of Trazodone Hydrochloride change in Q1 2026 in Germany?

Recovering insomnia and major depressive disorder procurement maintained buying. Firming synthesis intermediate and energy costs held the production floor. The market recovered to USD 48.5/KG from the Q3 2025 level.

Trazodone Hydrochloride Prices in India

Indian prices averaged USD 37.4/KG in Q1 2026, recovering about 1.9% from Q4 2025. Growing insomnia and antidepressant demand and firming import costs held the market near USD 37.4/KG.

Why did the price of Trazodone Hydrochloride change in Q1 2026 in India?

Growing insomnia and antidepressant export and domestic procurement maintained buying. Firming synthesis import costs raised the floor. The market recovered to USD 37.4/KG from the Q3 2025 level.

Quarterly Trazodone Hydrochloride Price Trends

Global Trazodone Hydrochloride prices dipped in Q3 2025 on synthesis intermediate cost softening before recovering through Q4 2025, Q1 2026, and Q2 2026. The average eased from USD 34.0/KG in Q2 2025 to USD 33.32/KG in Q3, then firmed to USD 33.99/KG in Q4, USD 34.67/KG in Q1 2026, and USD 36.75/KG in Q2 2026, a net gain of about 8.1% over the window. Triazolopyridine synthesis intermediate cost cycles and insomnia treatment and antidepressant procurement drove the recovery pattern.

What was Trazodone Hydrochloride Price in 2025?

Trazodone Hydrochloride prices declined modestly through 2025 on synthesis intermediate cost softening. The global average opened near USD 34.7/KG in Q1 2025 and closed at USD 33.99/KG in Q4, a marginal full-year decline of about 2.0%. Synthesis cost softening and competitive generic pricing maintained stable to slightly softer conditions before the H1 2026 recovery.

Trazodone Hydrochloride Prices in the United States in 2025

US prices fell from about USD 39.5/KG in Q1 2025 to USD 38.7/KG by Q4, a decline of 2.0%. Synthesis cost softening and adequate generic API supply maintained the modest downward trend.

Trazodone Hydrochloride Prices in China in 2025

Chinese prices fell from roughly USD 27.2/KG in Q1 2025 to USD 26.7/KG by Q4, a decline of 1.8%. Domestic API capacity and competitive pricing maintained the lowest level throughout.

Trazodone Hydrochloride Prices in Germany in 2025

German prices fell from about USD 48.5/KG in Q1 2025 to USD 47.5/KG by Q4, a decline of 2.1%. Synthesis intermediate softening maintained the downward trend.

Trazodone Hydrochloride Prices in India in 2025

Indian prices fell from roughly USD 37.4/KG in Q1 2025 to USD 36.7/KG by Q4, a decline of 1.9%. Synthesis import cost softening maintained downward pressure through the year.

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Expert Market Research tracks Trazodone Hydrochloride prices continuously across every major producing and consuming region. The team traces causation through triazolopyridine synthesis intermediate economics, insomnia and antidepressant prescription cycles, and regional API production capacity. Contact Expert Market Research today for Trazodone Hydrochloride pricing data, bespoke market analysis, and strategic procurement advisory.