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Global Congenital Adrenal Hyperplasia Treatment Market Share, Size, Growth, Analysis: By Diagnosis Method: Prenatal Testing, Physical Exam, Blood and Urine Tests, Genetic Testing; By Treatment Method: Medications, Physical Exams, Reconstructive Surgery; By Therapeutic Channel: Public, Private; Regional Analysis; Supplier Landscape; 2023-2031
Global Congenital Adrenal Hyperplasia Treatment Market Outlook
The global congenital adrenal hyperplasia treatment market is expected to grow at a CAGR of 7.75% during the forecast period 2023-2031. The growth can be attributed to the increasing prevalence of congenital adrenal hyperplasia and genetic abnormalities, government funding and assistance, along with joint research with large pharmaceutical businesses.
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Congenital Adrenal Hyperplasia Treatment Market Insights
Congenital adrenal hyperplasia (CAH) is a collection of hereditary disorders affecting the adrenal glands, which are a pair of walnut-sized structures located above the kidneys. Important hormones produced by the adrenal glands include the following:
- Mineralocorticoids, such as aldosterone, regulate sodium, and potassium levels.
- Cortisol regulates the body's response to disease or stress.
- Androgens, such as testosterone, are male sex hormones that are essential for both male and female growth and development.
The most common cause of CAH is a deficiency in the enzyme 21-hydroxylase. CAH is also known as 21-hydroxylase deficiency. The body requires this enzyme to produce enough levels of hormones. Other, far uncommon enzyme deficits can also induce CAH.
Parents who have CAH or are carriers of the disorder’s genetic alteration are most likely to increase the chances of CAH prevalence.
95% of all CAH cases are of two categories which are classical congenital adrenal hyperplasia and non-classic congenital adrenal hyperplasia. The more dangerous form of CAH is known as classic CAH. It can result in adrenal problems such as shock and coma. It can be lethal if not detected and treated promptly and is often diagnosed at birth. Classic CAH is divided into two subtypes: Saltwasting CAH and Simple—virilizing CAH. On the other hand, non-classic CAH is the mildest form of CAH.
Complications Associated with Congenital Adrenal Hyperplasia
Classic congenital adrenal hyperplasia (CAH) produces excessive water and salt loss in the urine. People are at risk of significant consequences such as electrolyte imbalances like potassium. These imbalances, if left unchecked, can result in arrhythmia, cardiac arrest, and death.
Non-classic CAH might also cause difficulties if left untreated. It can result in the following symptoms in people who were assigned male at birth (AMAB) early onset of puberty and short stature. With people assigned female at birth (AFAB) include symptoms like permanent male physical traits, irregular menstruation, and infertility.
According to the congenital adrenal hyperplasia treatment market research report, the market can be categorised into the following segments:
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Market Breakup by Diagnosis Method
- Prenatal Testing
- Aminocentesis
- Chorionic Villus Sampling
- Physical Exam
- Blood and Urine Tests
- Genetics Testing
Market Breakup by Treatment Method
- Medications
- Physical Exams
- Reconstructive Surgery
Market Breakup by Treatment Channel
- Public
- Private
Market Breakup by Region
- North America
- United States of America
- Canada
- Europe
- United Kingdom
- Germany
- France
- Italy
- Others
- Asia Pacific
- China
- Japan
- India
- ASEAN
- Australia
- Others
- Latin America
- Brazil
- Argentina
- Mexico
- Others
- Middle East and Africa
- Saudi Arabia
- United Arab Emirates
- Nigeria
- South Africa
- Others
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Global Congenital Adrenal Hyperplasia Epidemiology
In the United States and Europe, 1 in every 10,000 to 15,000 persons has classic CAH. Non-classic CAH affects around 1 out of every 100 to 200 persons. CAH, both classic and non-classic, affects people all over the world. The prevalence of the salt-wasting type of this condition may be as high as 1 in 282 Yupik Eskimos. Other types of CAH are far more uncommon. Non-classical CAH, on the other hand, affects around 1 in 100 to 1 in 200 people in the general population.
Global Congenital Adrenal Hyperplasia Treatment Market Drivers
The increasing prevalence of congenital adrenal hyperplasia and genetic abnormalities is driving the growth of the global congenital adrenal hyperplasia treatment market. Many government organisations are assisting R&D and manufacturers by providing research grants. The rising demand for better treatment and increased government backing has fuelled the growth of the global market. Government financing and assistance, along with collaborative research with large pharmaceutical firms, are expected to promote the market growth further in the future.
Therapeutic Landscape of the Congenital Adrenal Hyperplasia Treatment Market
To lessen the symptoms of CAH, newborns with classic CAH should begin therapy as soon as possible after birth. Steroids are used to replace the low hormone levels in classic CAH. Hydrocortisone is a kind of cortisol that is commonly given to infants and children.
Adults are given hydrocortisone, prednisone, or dexamethasone to replace cortisol. Fludrocortisone is another medication used to substitute aldosterone in patients with classic CAH. Salt-wasters may benefit from eating salty foods or taking salt pills.
Patients with classic CAH must take medication on a regular basis for the rest of their lives. Symptoms will recur if a patient stops taking medication.
If a person has non-classic CAH and does not have symptoms, they may not require therapy. Individuals experiencing symptoms like early puberty, excess body hair, irregular menstrual periods, and infertility are given low doses of the same cortisol-replacement medicine as people suffering from typical CAH.
In the case of classic CAH, girls with ambiguous external genitalia may require surgery. For example, if genital alterations have impaired urine flow, surgery is required. Non-classic CAH girls have normal genitals and do not require surgery.
Emerging Congenital Adrenal Hyperplasia Treatment
A few clinical studies on CAH treatment are presently in progress are as follows:
- Alternative dosing forms of hydrocortisone with altered pharmacokinetics or easier dose titration.
- Corticotropin-releasing hormone receptor antagonists that reduce corticotropin (ACTH) secretion and thus adrenal androgen secretion.
- Androgen Biosynthesis Inhibitor
- Gene Therapy Vector
Alternative dosage forms of hydrocortisone are being offered or will be soon, although the cost could be a barrier to use, at least in the United States market. Corticotropin-releasing hormone receptor antagonists and androgen biosynthesis inhibitors are now being tested in clinical trials.
Competitive Landscape
The report gives an in-depth analysis of the key players involved in the global congenital adrenal hyperplasia treatment market, sponsors manufacturing the drugs, and putting them through trials to get FDA approvals. The companies included in the market are as follows:
- Neurocrine Bioscience
- Johnson and Johnson
- Sanofi
- Zydus Lifesciences Ltd.
- GSK plc
- BridgeBio, Inc
- Millendo Therapeutics, Inc.
- Spruce Biosciences
- EffRx Pharmaceuticals
Key Highlights of the Report
| REPORT FEATURES | DETAILS |
|---|---|
| Base Year | 2022 |
| Historical Period | 2016-2022 |
| Forecast Period | 2023-2031 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Diagnosis Method |
|
| Breakup by Treatment Method |
|
| Breakup by Therapeutic Channel |
|
| Breakup by Region |
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| Market Dynamics |
|
| Supplier Landscape |
|
| Companies Covered |
|
*At Expert Market Research, we strive to always give you current and accurate information. The numbers depicted in the description are indicative and may differ from the actual numbers in the final EMR report.
1 Preface
1.1 Objectives of the Study
1.1.1 Research Objectives
1.1.2 Key Findings of the Report
1.2 Limitations of the Study and Scope for Future Research
2 Research Methodology
3 Executive Summary
4 Global Congenital Adrenal Hyperplasia Treatment Disease Overview
4.1 Guidelines and Stages
4.2 Pathophysiology
4.3 Screening and Diagnosis
4.4 Treatment Pathway
5 Patient Profile
5.1 Patient Profile Model
5.2 Patient Psychology and Emotional Impact Factors
5.3 Risk Assessment and Treatment Success Rate
6 Global Congenital Adrenal Hyperplasia Treatment Market
6.1 Global Congenital Adrenal Hyperplasia Treatment Market Overview
6.2 Global Congenital Adrenal Hyperplasia Treatment Market Analysis
6.2.1 Market Overview
6.2.1.1 Global Historical Congenital Adrenal Hyperplasia Treatment Market Volume (2016-2022)
6.2.1.2 Global Forecast Congenital Adrenal Hyperplasia Treatment Market Volume (2023-2031)
6.2.2 Global Congenital Adrenal Hyperplasia Treatment Market by Diagnosis Method
6.2.2.1 Market Overview
6.2.2.1.1 Prenatal Testing
6.2.2.1.1.1 Amniocentesis
6.2.2.1.1.2 Chorionic Villus Sampling
6.2.2.1.2 Physical Exam
6.2.2.1.3 Blood and Urine Tests
6.2.2.1.4 Genetic Testing
6.2.3 Global Congenital Adrenal Hyperplasia Treatment Market by Treatment Method
6.2.3.1 Market Overview
6.2.3.1.1 Medications
6.2.3.1.2 Physical Exams
6.2.3.1.3 Reconstructive Surgery
6.3 Global Congenital Adrenal Hyperplasia Treatment Market by Therapeutic Channel
6.3.1 Market Overview
6.3.1.1 Public
6.3.1.2 Private
6.4 Global Congenital Adrenal Hyperplasia Treatment Market by Region
6.4.1 Market Overview
6.4.1.1 North America
6.4.1.1.1 Historical Trend (2016-2022)
6.4.1.1.2 Forecast Trend (2023-2031)
6.4.1.2 Europe
6.4.1.2.1 Historical Trend (2016-2022)
6.4.1.2.2 Forecast Trend (2023-2031)
6.4.1.3 Asia Pacific
6.4.1.3.1 Historical Trend (2016-2022)
6.4.1.3.2 Forecast Trend (2023-2031)
6.4.1.4 Latin America
6.4.1.4.1 Historical Trend (2016-2022)
6.4.1.4.2 Forecast Trend (2023-2031)
6.4.1.5 Middle East and Africa
6.4.1.5.1 Historical Trend (2016-2022)
6.4.1.5.2 Forecast Trend (2023-2031)
7 North America Congenital Adrenal Hyperplasia Treatment Market
7.1 United States of America
7.1.1 Historical Trend (2016-2022)
7.1.2 Forecast Trend (2023-2031)
7.2 Canada
7.2.1 Historical Trend (2016-2022)
7.2.2 Forecast Trend (2023-2031)
8. Europe Congenital Adrenal Hyperplasia Treatment Market
8.1 United Kingdom
8.1.1 Historical Trend (2016-2022)
8.1.2 Forecast Trend (2023-2031)
8.2 Germany
8.2.3 Historical Trend (2016-2022)
8.2.4 Forecast Trend (2023-2031)
8.3 France
8.3.1 Historical Trend (2016-2022)
8.3.2 Forecast Trend (2023-2031)
8.4 Italy
8.4.1 Historical Trend (2016-2022)
8.4.2 Forecast Trend (2023-2031)
9 Asia Pacific Congenital Adrenal Hyperplasia Treatment Market
9.1 China
9.1.1 Historical Trend (2016-2022)
9.1.2 Forecast Trend (2023-2031)
9.2 Japan
9.2.1 Historical Trend (2016-2022)
9.2.2 Forecast Trend (2023-2031)
9.3 India
9.3.1 Historical Trend (2016-2022)
9.3.2 Forecast Trend (2023-2031)
9.4 ASEAN
9.4.1 Historical Trend (2016-2022)
9.4.2 Forecast Trend (2023-2031)
9.5 Australia
9.5.1 Historical Trend (2016-2022)
9.5.2 Forecast Trend (2023-2031)
10 Latin America Congenital Adrenal Hyperplasia Treatment Market
10.1 Brazil
10.1.1 Historical Trend (2016-2022)
10.1.2 Forecast Trend (2023-2031)
10.2 Argentina
10.2.1 Historical Trend (2016-2022)
10.2.2 Forecast Trend (2023-2031)
10.3 Mexico
10.3.1 Historical Trend (2016-2022)
10.3.2 Forecast Trend (2023-2031)
11 Middle East and Africa Congenital Adrenal Hyperplasia Treatment Market
11.1 Saudi Arabia
11.1.1 Historical Trend (2016-2022)
11.1.2 Forecast Trend (2023-2031)
11.2 United Arab Emirates
11.2.1 Historical Trend (2016-2022)
11.2.2 Forecast Trend (2023-2031)
11.3 Nigeria
11.3.1 Historical Trend (2016-2022)
11.3.2 Forecast Trend (2023-2031)
11.4 South Africa
11.4.1 Historical Trend (2016-2022)
11.4.2 Forecast Trend (2023-2031)
12 Current Scenario Evaluation
12.1 Emerging Therapies & Clinical Trials Synopsis
12.2 Patent Landscape
12.2.1 Patent Overview
12.2.1.1 Patent Status and Expiry
12.2.1.2 Timelines from Drug Development to Commercial Launch
12.2.1.3 New Drug Application
12.2.1.3.1 Documentation and Approval Process
12.3 Cost of Treatment
12.4 Regulatory Framework
12.4.1 Regulatory Overview
12.4.1.1 US FDA
12.4.1.2 EU EMA
12.4.1.3 INDIA CDSCO
12.4.1.4 JAPAN PMDA
12.4.1.5 Others
13 Challenges & Unmet Needs
13.1 Treatment Pathway Challenges
13.2 Compliance and Drop- out Analysis
13.3 Awareness and Prevention Gaps
14 Global Congenital Adrenal Hyperplasia Treatment Market Dynamics
14.1 Market Drivers and Constraints
14.2 SWOT Analysis
14.3 Porter’s Five Forces Model
14.4 Key Demand Indicators
14.5 Key Price Indicators
14.6 Market Events, Initiatives & Trends
14.7 Value Chain Analysis
15 Supplier Landscape
15.1 Neurocrine Bioscience
15.1.1 Company Overview
15.1.2 Product Portfolio
15.1.3 Demographic Reach and Achievements
15.1.4 Mergers and Acquisitions
15.1.5 Certifications
15.2 Johnson and Johnson
15.2.1 Company Overview
15.2.2 Product Portfolio
15.2.3 Demographic Reach and Achievements
15.2.4 Mergers and Acquisitions
15.2.5 Certifications
15.3 Sanofi
15.3.1 Company Overview
15.3.2 Product Portfolio
15.3.3 Demographic Reach and Achievements
15.3.4 Mergers and Acquisitions
15.3.5 Certifications
15.4 Zydus Lifesciences Ltd.
15.4.1 Company Overview
15.4.2 Product Portfolio
15.4.3 Demographic Reach and Achievements
15.4.4 Mergers and Acquisitions
15.4.5 Certifications
15.5 GSK plc
15.5.1 Company Overview
15.5.2 Product Portfolio
15.5.3 Demographic Reach and Achievements
15.5.4 Mergers and Acquisitions
15.5.5 Certifications
15.6 BridgeBio, Inc.
15.6.1 Company Overview
15.6.2 Product Portfolio
15.6.3 Demographic Reach and Achievements
15.6.4 Mergers and Acquisitions
15.6.5 Certifications
15.7 Millendo Therapeutics, Inc.
15.7.1 Company Overview
15.7.2 Product Portfolio
15.7.3 Demographic Reach and Achievements
15.7.4 Mergers and Acquisitions
15.7.5 Certifications
15.8 Spruce Biosciences
15.8.1 Company Overview
15.8.2 Product Portfolio
15.8.3 Demographic Reach and Achievements
15.8.4 Mergers and Acquisitions
15.8.5 Certifications
15.9 EffRx Pharmaceuticals
15.9.1 Company Overview
15.9.2 Product Portfolio
15.9.3 Demographic Reach and Achievements
15.9.4 Mergers and Acquisitions
15.9.5 Certifications
16 Recommendations and Discussion
17 Global Congenital Adrenal Hyperplasia Treatment Distribution Model (Additional Insight)
17.1 Overview
17.2 Potential Distributors
17.3 Key Parameters for Distribution Partner Assessment
18 Payment Methods (Additional Insight)
18.1 Government Funded
18.2 Private Insurance
18.3 Out-of-Pocket
*Additional insights provided are customisable as per client requirements.
Key Questions Answered in the Report
The market is likely to grow at a CAGR of 7.75% during the forecast period of 2023-2031.
The market growth is being driven by the increasing prevalence of congenital adrenal hyperplasia and genetic abnormalities.
Based on the diagnosis, the market is categorised into prenatal testing, physical exam, blood and urine tests, and genetic testing, among others.
Based on the treatment, the market is segmented into medications, physical exams, and reconstructive surgery, among others.
The treatment channels in this market are public and private.
The different regions in the market are North America, Europe, Asia Pacific, Latin America and the Middle East and Africa.
The key companies involved in this market are Neurocrine Bioscience, Johnson and Johnson, Sanofi, Zydus Lifesciences Ltd., GSK plc, BridgeBio, Inc, Millendo Therapeutics, Inc., Spruce Biosciences, and EffRx Pharmaceuticals, among others.
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