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Global Tonic-Clonic Seizures Treatment Market Share, Size, Growth, Analysis, Forecast: By Product Type: Solid Dosage, Liquid Dosage; By Drug Classification: Barbiturates, Hydantoin, Phenyltriazine, Iminostilbenes, Benzodiazepines, Others; By Route of Administration; By Therapeutic Channel; Regional Analysis; Supplier Landscape; 2023-2031
Global Tonic-Clonic Seizures Treatment Market Outlook
The global tonic-clonic seizures treatment market attained a value of USD 3.2 million in 2021. The market is estimated to grow at a CARG of 6% and is expected to reach a value of USD 5.4 million by 2030. The market growth is expected to be driven by the increased incidences of epilepsy.
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Tonic-Clonic Seizures Insights
"Grand mal" is an older term for this type of seizure. It combines the characteristic of tonic and clonic seizures, as the name implies. Tonic refers to stiffening, while clonic refers to rhythmical jerking.
The tonic phase occurs first and shows the following signs:
- All the muscles become tense.
- A cry or groan when the air is forced past the vocal cords.
- The individual loses consciousness and collapses on the floor.
- A person may bite the inside of their cheek or their tongue. If this occurs, the saliva may appear bloody.
Followed by the tonic, comes the clonic phase which shows the following signs:
- The arms, and often the legs, begin to jerk quickly and rhythmically, bending and relaxing at the elbows, hips, and knees.
- The jerking slows and eventually stops after a few minutes.
Some common causes of seizures in newborns are brain malformations, lack of oxygen during birth, low levels of blood sugar, blood calcium, blood magnesium, bleeding in the brain, and maternal drug use. In children, the common causes are infection and brain tumours. In adults, the causes are congenital conditions, genetic factors, and progressive brain disease. In the geriatric population, the common causes are stroke, Alzheimer’s disease, and head trauma.
For the diagnosis of the tonic-clonic, the medical and history need to be reviewed prior to the following tests, neurological exams, blood tests, electroencephalogram (EEG), Computerized tomography (CT) scan, Magnetic resonance imaging (MRI), Positron emission tomography (PET), and Single-photon emission computerised tomography (SPECT).
According to the global tonic-clonic seizures treatment market research report, the market can be categorised into the following segments:
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Market Break up by Product Type
- Solid Dosage
- Tablets
- Capsules
- Liquid Dosage
- Injectables
- Suspension
Market Break up by Drug Classification
- Barbiturates
- Hydantoin
- Phenyltriazines
- Iminostilbenes
- Benzodiazepines
- Aliphatic Carboxylic Acid
- Others
Market Break up by Route of Administration
- Oral
- Parenteral
- Others
Market Break up by Therapeutic Channel
- Public
- Private
Market Break up Region
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East & Africa
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Tonic-Clonic Epidemiology
Seizures account for 1 to 2% of all emergency visits in the United States. Seizures are reported to affect approximately 11% of people in the United States at some point in their lives. Males experience 1.85 times more acute symptomatic seizures than females, with a lifetime risk of 5.0% in males and 2.7% in females. African Americans are overrepresented in the emergency department compared to white Americans, with an odd ratio of 1:4. Seizures have a bimodal age distribution, occurring in infants as a result of febrile illness and in patients over the age of 75 as a result of structural damage caused by a stroke or trauma.
Because of the increased prevalence of tonic-clonic seizures, the North American region is expected to dominate the market during the forecast period. Cases of Post-Traumatic Epilepsy (PTE) and Post-Traumatic Seizures (PTS) have increased due to increased brain damage from car accidents and other causes.
Global Tonic-Clonic Treatment Market Trends
The continued cooperation of many organisations, institutions, and governments in the fight against stigma associated with epilepsy and seizures has resulted in increased awareness and a corresponding increase in demand for treatment. For example, the World Health Organization (WHO), the International League Against Epilepsy (ILAE), and the International Bureau for Epilepsy (IBE) have launched a global campaign to "bring the disease out of the shadows," increasing public and private efforts to improve care and reduce disease burden. These programmes have raised the profile of epilepsy in many countries, resulting in regional declarations in all six WHO regions.
Increased clinical trial activity has resulted in a stronger product pipeline. Technological advancements and increased investments in R&D activities have paved the way for a variety of novel treatment options. Furthermore, increased healthcare budget and spending and improved healthcare infrastructure are expected to support market growth over the forecast period.
Therapeutic Landscape
Medication is used by the majority of people to control the seizures.
Many medications for the treatment of tonic-clonic seizures have been approved by the United States Food and Drug Administration (FDA), including: carbamazepine (Carbatrol, Tegretol, Epitol, Equetro) (Carbatrol, Tegretol, Epitol, Equetro), lamotrigine (Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR), (Lamictal, Lamictal CD, Lamictal ODT, Lamictal XR), levetiracetam (Elepsia XR, Keppra, Keppra XR, Spritam) (Elepsia XR, Keppra, Keppra XR, Spritam), lorazepam (Ativan) (Ativan), oxcarbazepine (Trileptal, Oxtellar XR) (Trileptal, Oxtellar XR), phenytoin phenobarbital (Dilantin, Phenytek)
Whereas multiple supplements or alternative treatments are also given to reduces the risk the seizures:
- Vagus nerve stimulation (VNS) is the implantation of an electrical device in the neck that automatically stimulates the vagus nerve.
- NeuroPace's trademarked programme is called responsive neurostimulation (RNS). When the RNS System detects a seizure or unusual electrical activity in the brain, it sends stimulation to the brain. Like VNS, necessitates the implantation of an electrical device.
- Deep brain stimulation (DBS) involves the placement of electrodes in the thalamus, a region of the brain. The DBS device can deliver either continuous or intermittent stimulation (unlike RNS, which only sends stimulation when a seizure is detected). DBS aims to modulate specific brain circuits, which should help prevent or reduce the frequency of seizures.
Also, a ketogenic diet, which is high in fat and low in carbohydrates, is also said to aid in the reduction of certain types of seizures in some people.
Competitive Landscape
The report gives an in-depth analysis of the key players involved in the global Tonic-Clonic Seizures Treatment Market, sponsors manufacturing the therapies, and putting them through trials to get FDA approvals. The companies included in the market are as follows:
- Johnson & Johnson
- GSK plc
- Takeda Pharmaceutical
- Teva Pharmaceutical Industries
- UCB Celltech
- Abbott Laboratories
- Sanofi
- Pfizer Inc.
- Novartis AG
Key Highlights of the Report
| REPORT FEATURES | DETAILS |
|---|---|
| Base Year | 2022 |
| Historical Period | 2016-2022 |
| Forecast Period | 2023-2031 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Product Type |
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| Breakup by Drug Classification |
|
| Breakup by Route of Administration |
|
| Breakup by Therapeutic Channel |
|
| Breakup by Region |
|
| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
|
*At Expert Market Research, we strive to always give you current and accurate information. The numbers depicted in the description are indicative and may differ from the actual numbers in the final EMR report.
1 Preface
1.1 Objectives of the Study
1.2 Key Assumptions
1.3 Report Coverage – Key Segmentation and Scope
2 Research Methodology
3 Executive Summary
4 Global Tonic-Clonic Seizures Overview
4.1 Guidelines and Stages
4.2 Pathophysiology
4.3 Screening and Diagnosis
4.4 Treatment Pathway
5 Patient Profile
5.1 Patient Profile Model
5.2 Patient Psychology and Emotional Impact Factors
5.3 Risk Assessment and Treatment Success Rate
6 Current Scenario Evaluation
6.1 Emerging Therapies and Clinical trials Synopsis
6.2 Patent Landscape
6.2.1 Patent Overview
6.2.1.1 Patent Status and Expiry
6.2.1.2 Timelines from Drug Development to Commercial Launch
6.2.1.3 New Drug Application
6.2.1.3.1 Documentation and Approval Process
6.3 Cost of Treatment
6.4 Regulatory Framework
6.4.1 Regulatory Overview
6.4.1.1 US FDA
6.4.1.2 EU EMA
6.4.1.3 INDIA CDSCO
6.4.1.4 JAPAN PMDA
6.4.1.5 Others
7 Challenges and Unmet Needs
7.1 Treatment Pathway Challenges
7.2 Compliance and Drop- out Analysis
7.3 Awareness and Prevention Gaps
8 Global Tonic-Clonic Seizures Treatment Market
8.1 Global Tonic-Clonic Seizures Treatment Market Overview
8.2 Global Tonic-Clonic Seizures Treatment Market Analysis
8.2.1 Market Overview
8.2.1.1 Global Historical Tonic-Clonic Seizures Treatment Market Historical Value (2016-2022)
8.2.1.2 Global Forecast Tonic-Clonic Seizures Treatment Market Forecast Value (2023-2031)
8.2.2 Global Tonic-Clonic Seizures Treatment Market by Product Type
8.2.2.1 Market Overview
8.2.2.1.1 Solid Dosage
8.2.2.1.1.1 Tablets
8.2.2.1.1.2 Capsules
8.2.2.1.2 Liquid Dosage
8.2.2.1.2.1 Injectables
8.2.2.1.2.2 Suspension
8.2.3 Global Tonic-Clonic Seizures Treatment Market by Drug Classification
8.2.3.1 Market Overview
8.2.3.1.1 Barbiturates
8.2.3.1.2 Hydantoin
8.2.3.1.3 Phenyltriazine
8.2.3.1.4 Iminostilbenes
8.2.3.1.5 Benzodiazepines
8.2.3.1.6 Aliphatic Carboxylic Acid
8.2.3.1.7 Others
8.2.4 Global Tonic-Clonic Seizures Treatment Market by Route of Administration
8.2.4.1 Market Overview
8.2.4.1.1 Oral
8.2.4.1.2 Parenteral
8.2.4.1.3 Others
8.3 Global Tonic-Clonic Seizures Treatment Market by Therapeutic Channel
8.3.1 Market Overview
8.3.1.1 Public
8.3.1.2 Private
8.4 Global Tonic-Clonic Seizures Treatment Market by Region
8.4.1 Market Overview
8.4.1.1 North America
8.4.1.2 Europe
8.4.1.3 Asia Pacific
8.4.1.4 Latin America
8.4.1.5 Middle East and Africa
9 North America Tonic-Clonic Seizures Treatment Market
9.1 Market Share by Country
9.2 United States of America
9.2.1 Historical Trend (2016-2022)
9.2.2 Forecast Trend (2023-2031)
9.3 Canada
9.3.1 Historical Trend (2016-2022)
9.3.2 Forecast Trend (2023-2031)
10 Europe Tonic-Clonic Seizures Treatment Market
10.1 Market Share by Country
10.2 United Kingdom
10.2.1 Historical Trend (2016-2022)
10.2.2 Forecast Trend (2023-2031)
10.3 Germany
10.3.1 Historical Trend (2016-2022)
10.3.2 Forecast Trend (2023-2031)
10.4 France
10.4.1 Historical Trend (2016-2022)
10.4.2 Forecast Trend (2023-2031)
10.5 Italy
10.5.1 Historical Trend (2016-2022)
10.5.2 Forecast Trend (2023-2031)
10.6 Others
11 Asia Pacific Tonic-Clonic Seizures Treatment Market
11.1 Market Share by Country
11.2 China
11.2.1 Historical Trend (2016-2022)
11.2.2 Forecast Trend (2023-2031)
11.3 Japan
11.3.1 Historical Trend (2016-2022)
11.3.2 Forecast Trend (2023-2031)
11.4 India
11.4.1 Historical Trend (2016-2022)
11.4.2 Forecast Trend (2023-2031)
11.5 ASEAN
11.5.1 Historical Trend (2016-2022)
11.5.2 Forecast Trend (2023-2031)
11.6 Australia
11.6.1 Historical Trend (2016-2022)
11.6.2 Forecast Trend (2023-2031)
11.7 Others
12 Latin America Tonic-Clonic Seizures Treatment Market
12.1 Market Share by Country
12.2 Brazil
12.2.1 Historical Trend (2016-2022)
12.2.2 Forecast Trend (2023-2031)
12.3 Argentina
12.3.1 Historical Trend (2016-2022)
12.3.2 Forecast Trend (2023-2031)
12.4 Mexico
12.4.1 Historical Trend (2016-2022)
12.4.2 Forecast Trend (2023-2031)
12.5 Others
13 Middle East and Africa Tonic-Clonic Seizures Treatment Market
13.1 Market Share by Country
13.2 Saudi Arabia
13.2.1 Historical Trend (2016-2022)
13.2.2 Forecast Trend (2023-2031)
13.3 United Arab Emirates
13.3.1 Historical Trend (2016-2022)
13.3.2 Forecast Trend (2023-2031)
13.4 Nigeria
13.4.1 Historical Trend (2016-2022)
13.4.2 Forecast Trend (2023-2031)
13.5 South Africa
13.5.1 Historical Trend (2016-2022)
13.5.2 Forecast Trend (2023-2031)
13.6 Others
14 Global Tonic-Clonic Seizures Treatment Market Dynamics
14.1 Market Drivers and Constraints
14.2 SWOT Analysis
14.3 Porter’s Five Forces Model
14.4 Key Demand Indicators
14.5 Key Price Indicators
14.6 Market Events, Initiatives, and Trends
14.7 Value Chain Analysis
15 Supplier Landscape
15.1 Johnson & Johnson
15.1.1 Company Overview
15.1.2 Product Portfolio
15.1.3 Demographic Reach and Achievements
15.1.4 Mergers and Acquisitions
15.1.5 Certifications
15.2 GSK plc
15.2.1 Company Overview
15.2.2 Product Portfolio
15.2.3 Demographic Reach and Achievements
15.2.4 Mergers and Acquisitions
15.2.5 Certifications
15.3 Takeda Pharmaceutical
15.3.1 Company Overview
15.3.2 Product Portfolio
15.3.3 Demographic Reach and Achievements
15.3.4 Mergers and Acquisitions
15.3.5 Certifications
15.4 Teva Pharmaceutical Industries
15.4.1 Company Overview
15.4.2 Product Portfolio
15.4.3 Demographic Reach and Achievements
15.4.4 Mergers and Acquisitions
15.4.5 Certifications
15.5 UCB Celltech
15.5.1 Company Overview
15.5.2 Product Portfolio
15.5.3 Demographic Reach and Achievements
15.5.4 Mergers and Acquisitions
15.5.5 Certifications
15.6 Abbott Laboratories
15.6.1 Company Overview
15.6.2 Product Portfolio
15.6.3 Demographic Reach and Achievements
15.6.4 Mergers and Acquisitions
15.6.5 Certifications
15.7 Sanofi
15.7.1 Company Overview
15.7.2 Product Portfolio
15.7.3 Demographic Reach and Achievements
15.7.4 Mergers and Acquisitions
15.7.5 Certifications
15.8 Pfizer Inc.
15.8.1 Company Overview
15.8.2 Product Portfolio
15.8.3 Demographic Reach and Achievements
15.8.4 Mergers and Acquisitions
15.8.5 Certifications
15.9 Novartis AG
15.9.1 Company Overview
15.9.2 Product Portfolio
15.9.3 Demographic Reach and Achievements
15.9.4 Mergers and Acquisitions
15.9.5 Certifications
16 Global Tonic-Clonic Seizures Treatment Market- Drug Distribution Model (Additional Insight)
16.1 Overview
16.2 Potential Distributors
16.3 Key Parameters for Distribution Partner Assessment
17 Payment Methods (Additional Insight)
17.1 Government Funded
17.2 Private Insurance
17.3 Out-of-Pocket
*Additional insights provided are customisable as per client requirements.
Key Questions Answered in the Report
The market was estimated to reach about a value of USD 3.2 million in 2021.
The market is expected to grow at a CAGR of 6% during the forecast period of 2023-2031.
The market is likely to attain a value of USD 5.4 million by 2030.
The market is segmented based on the product type, drug classification, route of administration, therapeutic channel and region.
The product types are bifurcated into Solid Dosage (Tablets, Capsules) and Liquid Dosage forms (Injectables, Suspension).
The treatment drugs are classified into Barbiturates, Hydantoin, Phenyltriazines, Iminostilbenes, Benzodiazepines, and Aliphatic Carboxylic Acid, among others.
The market growth is expected to be driven by increased incidences of the epilepsy.
The regions involved in this market are North America, Latin America, Asia Pacific, Europe, Middle East and Africa.
Prolonged seizures are clearly capable of causing brain damage. Isolated, brief seizures are likely to result in negative changes in brain function and possibly brain cell loss.
The key companies involved in the market are Johnson & Johnson, GSK plc, Takeda Pharmaceutical, Teva Pharmaceutical Industries, UCB Celltech, Abbott Laboratories, Sanofi, Pfizer Inc., and Novartis AG, among others.
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