Global Bioadhesive Microspheres Market Report and Forecast 2024-2032

Global Bioadhesive Microspheres Market Outlook

The global bioadhesive microspheres market is expected to grow at a CAGR of 8.5% during the period 2024-2032. North America and Europe are expected to be key markets.

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Global Market Likely to be Driven by Advancements in Drug Carrier Technologies and Increasing Applications of Bioadhesive Microspheres as Drug Carrier

The notion of controlled drug delivery has been conventionally used to achieve particular release rates or spatial targeting of active ingredients. Bioadhesion has been extensively researched over the last decade and applied to enhance the performance of drug delivery systems. Advancements in polymer science and drug carrier technologies have led to the development of novel drug carriers such as bioadhesive microspheres that have increased the use of “bioadhesion” in drug delivery. Bioadhesive microspheres display protracted residence time at site of application or absorption, and enable a close contact with underlying absorption surface, contributing to improved and/or better therapeutic performance of drugs. In recent years, bioadhesive microspheres have been advanced for buccal, oral, rectal, ocular, nasal and vaginal routes for systemic or local effects.

Mucoadhesive polymers have gained much interest among pharmaceutical scientists as a means of enhancing drug delivery by increasing residence time and contact time with mucous membranes.

Mucoadhesion refers to a state in which two components (one of biological origin), are held together for an extended duration of time through interfacial forces. Multiple polymers have exhibited bioadhesive characteristics been used in the development of different conventional and novel drug delivery systems. These carriers have been shown to enhance local therapeutic activity as well as increase the systemic availability of the drugs by increasing residence time at the site of application.

Bioadhesive polymers may be broadly classified into two categories - specific and nonspecific. According to their properties, specific bioadhesive polymers (such as lectins, and fimbrins) show the capability to adhere to particular chemical structures within the biological molecules; nonspecific bioadhesive polymers (such as polyacrylic acid [PAA] and cyanoacrylates) show capability to bind with the cell surfaces and the mucosal layer.

Key Bioadhesive Microspheres Expected to Boost Market Growth

The use of key bioadhesive microspheres is likely to stimulate growth of global bioadhesive microspheres market. Some important bioadhesive polymers used in drug delivery include:

Chitosan - A biodegradable, nontoxic polymer attained by deacetylation of the N-acetyl glucosamine units of chitin, usually by hydrolysis under alkali conditions at high temperature. It possesses very good bioadhesive properties; it is a biocompatible, pH-dependent cationic polymer, soluble in water up to pH 6.2. Chitosan (along with its derivatives) has been employed in the formulation of multiple mucoadhesive-controlled drug delivery systems.

Carbopol - High molecular weight polymers of acrylic acid cross-linked with allyl sucrose or allyl ethers of penta erythritol; employed as suspending agent or viscosity boosting agent, dry and wet binder, and rate regulating agent in tablets, enzyme inhibitor of intestinal protease in peptide containing dosage form, etc. Carbopol exhibits outstanding mucoadhesive properties in comparison with other polymers (such as cellulose derivatives and polyvinyl alcohol). Different mucoadhesive formulations carrying carbopol have been developed; these were found to show excellent mucoadhesive property and release the drug in a regulated fashion for a longer period of time.

Alginate - Alginates are random anionic, linear polymers comprising different ratios of glucuronic and manuronic acid units. Alginate has been employed in several biomedical applications, including drug delivery systems; these are biodegradable, biocompatible, and mucoadhesive. Calcium alginate matrix is generally used for drug delivery systems including gels, films, beads, microparticles, and sponges.

Sodium carboxymethyl cellulose (Na CMC) – A cost-effective, commercial, soluble, and polyanionic polysaccharide derivative of cellulose employed in medicine as an emulsifying agent in cosmetics and pharmaceuticals.

Hydroxypropyl methyl cellulose (HPMC) – A semisynthetic, inert, viscoelastic polymer employed as an ophthalmic lubricant, suspending agent, emulsifier, thickening agent, and controlled-delivery component in oral medicaments, is present in several commercial products. It is also known as hypermellose, and is a thermosenstive polymer the aqueous solution of which converts into gel when heated up to critical temperature. It displays good bioadhesive property owing to its capability to exhibit strong hydrogen bonding with the mucin present in the mucosal layer. HPMC as mucoadhesive polymer has bee employed in various films, tablets, and gel formulations.

Development of New Drug Delivery Systems Likely to Drive Market Growth

Companies are looking to develop novel drug delivery system of current drug molecule to maximize their impact in terms of therapeutic action and patient protection. Such developments are expected to boost growth of global bioadhesive microspheres market. Mucoadhesive polymers might offer an important tool to enhance the bioavailability of the active agent by improving residence time at the delivery site. The most extensively researched and accepted polymers for mucoadhesion are the hydrophilic, high molecular weight, anionic molecules such as carbomers. Focus has also been on novel second generation polymers such as thiolated polymers, lectins, and lecithins. Several potential mucoadhesive systems are under investigation, and may be introduced to the market in the near future.

Market Segmentation

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By material, the market is segmented into:

• Natural Polymers 
• Synthetic Polymers (further broken down by type as given below)
  • Biodegradable
  • Non-biodegradable

By route of drug delivery, the market is divided into:

• Oral
• Nasal 
• Ocular 
• Colorectal 
• Others

By end use, the market is divided into:

• Hospitals 
• Clinics
• Academic and Research Institutes
• Pharmaceutical and Biotechnology Industries
• Others

By region, the market is classified into:

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East and Africa

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Key Industry Players in the Market

The report presents a detailed analysis of the following key players in the global bioadhesive microspheres market, looking into their capacity, and latest developments like capacity expansions, plant turnarounds, and mergers and acquisitions:

• Henkel AG & Co. KGaA
• Ashland Global Holdings Inc. 
• Luminex Corporation 
• Adhesives Research, Inc.
• ABK Biomedical Inc.
• Others

The EMR report gives an in-depth insight into the industry by providing a SWOT analysis as well as an analysis of Porter’s Five Forces model.

Key Highlights of the Report