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Healthcare and Pharmaceuticals

Global Bioadhesive Microspheres Mar...

Historical and Forecast Market Trends

2018-34

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The global bioadhesive microspheres market is expected to be driven by advancements in drug carrier technologies and increasing applications of bioadhesive microspheres as drug carrier. North America and Europe are expected to be key markets.

The oral route of drug administration is a convenient and preferred means of drug delivery to systemic circulation of body. Drugs easily absorbed from the gastrointestinal tract (GIT) and with short half-lives are eliminated quickly from systemic circulation. Frequent dosing of such drugs is needed to attain suitable therapeutic activity. The development of microspheres forms an important part of particulate drug delivery systems due to their small size and efficient carrier capacity.

Controlled release drug delivery systems (CRDDS) provide drug release at a predetermined, anticipated, and regulated rate. A controlled release drug delivery system is capable of attaining benefits such as maintenance of optimum therapeutic drug concentration in the blood with expectable and reproducible release rates for prolonged periods of time, improvement of activity of shorter half life drugs, side effect elimination, reduced frequency of dosing and drug wastage, optimized therapy and better patient compliance. Novel drug delivery systems such as mucoadhesive microsphere drug delivery system may improve drug action and help drive the global bioadhesive microspheres market.

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Microspheres are carrier linked drug delivery system wherein particle size ranges from 1-1000 μm in diameter with a core of drug and outer layers of polymer as coating material. However, success of these microspheres is restricted due to their long residence time at the absorption site. This warrants a means to provide an intimate contact of the drug delivery system with the absorbing membrane. Coupling bioadhesion characteristics to microspheres and developing “mucoadhesive microspheres” can achieve this end. Mucoadhesive microspheres offer advantages such as efficient absorption and enhanced bioavailability of drugs due to a high surface to volume ratio, a more intimate contact with the mucus layer, and particular targeting of drugs to the absorption site.

Key bioadhesive microspheres expected to boost the global bioadhesive microspheres market include Chitosan, Carbopol, Alginate, Sodium carboxymethyl cellulose (Na CMC), and Hydroxypropyl methyl cellulose (HPMC).

Companies are engaged in developing novel drug delivery system of current drug molecule to maximize their impact in terms of therapeutic action and patient protection. Mucoadhesive polymers might offer an important tool to enhance the bioavailability of the active agent by improving residence time at the delivery site. Multiple potential mucoadhesive systems are under study, and may be introduced to the market in the near future.

Market Analysis by Material, Route of Drug Delivery, End Use and Region:

  • By material, the market is segmented into Natural Polymers and Synthetic Polymers (further broken down by type into Biodegradable and Non-biodegradable).
  • By route of drug delivery, the market is divided into Oral, Nasal, Ocular, Colorectal, and Others.
  • By end use, the market is divided into Hospitals, Clinics, Academic and Research Institutes, Pharmaceutical and Biotechnology Industries, and Others.
  • By region, the market is classified into North America, Europe, Asia Pacific, Latin America, and Middle East and Africa.

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