Explore Our Diverse Range Of Offerings
From detailed reports to experts services offered in 15+ Industry Domains
Report
Press Release
Blogs
Industry Statistics
Add 2 More Reports For 20% off

Report Overview

Cardiac amyloidosis is a progressive disorder caused by the deposition of misfolded amyloid proteins within the heart, leading to impaired cardiac function and heart failure. According to Rare Disease Advisor, cardiac amyloidosis is present in approximately 10% of patients with heart failure worldwide, with wild-type transthyretin-mediated amyloid cardiomyopathy accounting for most cases. According to the cardiac amyloidosis epidemiology forecast by Expert Market Research, the rising disease burden is expected to support increased diagnosis and treatment demand.

2025

Base Year

2019-2025

Historical Period

2026-2035

Forecast Period

Cardiac Amyloidosis – Number of Cases by Year

Read more about this report - Request a Free Sample

Cardiac Amyloidosis Epidemiology Forecast Report Coverage

Expert Market Research's “Cardiac Amyloidosis Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of cardiac amyloidosis. It projects the future incidence and prevalence rates of cardiac amyloidosis cases across various populations. The study covers age, gender, and type as major determinants of the cardiac amyloidosis population. The report highlights patterns in the prevalence of cardiac amyloidosis over time and projects future trends based on multiple variables.

The report provides a comprehensive overview of the disease, as well as historical and projected data on the epidemiology of cardiac amyloidosis in the 8 major markets.

Regions Covered

  • United States
  • Germany
  • France
  • Italy
  • Spain
  • United Kingdom
  • Japan
  • India

Cardiac Amyloidosis Understanding: Disease Overview

Cardiac amyloidosis is a progressive disorder characterized by the deposition of misfolded amyloid proteins within the heart muscle, leading to increased ventricular stiffness, impaired cardiac function, and ultimately heart failure if left untreated. The condition develops when abnormal proteins accumulate in the extracellular space, disrupting normal myocardial structure and function. The two primary types are transthyretin amyloid cardiomyopathy (ATTR-CM), which includes hereditary and wild-type forms, and immunoglobulin light-chain amyloidosis (AL amyloidosis). Early recognition using multimodal imaging and clinical assessment is essential for improving diagnosis, disease management, and long-term patient outcomes.

Key Report Insights

Parameter

Insight

Largest Patient Pool

United States

Fastest Growing Region

India

High-Risk Population

Older adults, particularly individuals aged 65 years and above, and patients with hereditary transthyretin gene mutations.

Key Diagnostic Method

Echocardiography combined with cardiac magnetic resonance imaging and nuclear scintigraphy.

Major Risk Factor

Aging and transthyretin protein instability or plasma cell dyscrasia.

Major gap in the market

Underdiagnosis due to nonspecific symptoms and delayed recognition in routine clinical practice.

Cardiac Amyloidosis Epidemiology Perspective

The cardiac amyloidosis epidemiology division offers information on the patient pool from history to the present as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the cardiac amyloidosis epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for cardiac amyloidosis and their trends. The data is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

Epidemiology Segment

Key Insights

Diagnosed Prevalent Cases of the Disease

Cardiac amyloidosis is increasingly recognized because of advances in diagnostic techniques and greater disease awareness. According to Rare Disease Advisor, cardiac amyloidosis is present in approximately 10% of patients with heart failure worldwide, with wild-type transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) accounting for the majority of cases. As reported by Jonathan D. Knott et al., 2025, the overall prevalence of cardiac amyloidosis among adults undergoing transthoracic echocardiography in the United States was 1.25%, including 0.76% ATTR and 0.47% AL cardiac amyloidosis.

Gender-Specific Cases of the Disease

Cardiac amyloidosis demonstrates distinct gender-related differences in disease recognition and diagnosis. As per Julia Vogel et al., 2025, women represented 14.2% of 240 patients diagnosed with ATTR-CM, while men accounted for the majority of cases. The median diagnostic delay was significantly longer in women (750 vs. 86 days), highlighting potential underdiagnosis in female patients.

Age-Specific Cases of the Disease

The prevalence of cardiac amyloidosis increases substantially with advancing age. According to Jonathan D. Knott et al., 2025, prevalence increased from 0.14% in individuals younger than 50 years to 2.30% among those aged 80–89 years, the highest reported age group. ATTR cardiac amyloidosis peaked in patients aged 80–89 years, whereas AL cardiac amyloidosis was most common in those aged 60–69 years.

Ethnicity-Wise Cases of the Disease

The epidemiology of cardiac amyloidosis may vary across different ethnic populations because of differences in genetic predisposition, disease subtype distribution, healthcare accessibility, and diagnostic practices. Understanding ethnicity-based patterns can support earlier diagnosis, appropriate disease management, and improved epidemiological assessment across diverse populations.

Mortality and Survival Analysis of the Disease

Cardiac amyloidosis continues to be associated with considerable mortality despite improvements in diagnosis. According to Abdalhakim Shubietah et al., 2025, the age-adjusted mortality rate increased from 0.261 in 1999 to 0.608 in 2020, representing an average annual increase of 3.96%. As per Svenja Ney et al., 2023, the median survival following diagnosis in Germany was 2.5 years, with a 9% reduction in mortality risk during the latter half of the study period.

Type-Specific Disease Burden and Epidemiology Analysis

Disease Type

Prevalence

ATTR Cardiac Amyloidosis

As reported by Jonathan D. Knott et al., 2025, ATTR cardiac amyloidosis had a prevalence of 0.76% among adults undergoing transthoracic echocardiography in the United States. According to Rare Disease Advisor, wild-type ATTR-CM accounts for the majority of cardiac amyloidosis cases globally.

AL Cardiac Amyloidosis

According to Jonathan D. Knott et al., 2025, AL cardiac amyloidosis accounted for 0.47% of the evaluated U.S. cohort and was less prevalent than ATTR cardiac amyloidosis within the study population.

Cardiac Amyloidosis – Number of Cases by Country

Read more about this report - Request a Free Sample

Country-wise Cardiac Amyloidosis Epidemiology

The cardiac amyloidosis epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.

Country

Key Insights

United States

Cardiac amyloidosis is being increasingly identified through enhanced diagnostic evaluation. As reported by Jonathan D. Knott et al., 2025, the prevalence among adults undergoing transthoracic echocardiography was 1.25%, including 0.76% ATTR and 0.47% AL cardiac amyloidosis. According to Rare Disease Advisor, cardiac amyloidosis is present in approximately 10% of patients with heart failure worldwide, with ATTR-CM representing the predominant subtype.

Germany

The epidemiological burden of cardiac amyloidosis has increased over time with improved disease recognition. As per Svenja Ney et al., 2023, prevalence increased from 15.5 to 47.6 per 100,000 person-years, while incidence rose from 4.8 to 11.6 per 100,000 person-years between 2009 and 2018. The study also reported a median survival of 2.5 years following diagnosis.

France

Epidemiological assessment of cardiac amyloidosis in France focuses on improving disease recognition, early diagnosis, and evaluation of the affected patient population to better understand the national disease burden.

Italy

Epidemiological studies in Italy primarily emphasize the identification of affected patients, assessment of disease burden, and enhancement of diagnostic approaches to support timely detection and management of cardiac amyloidosis.

Spain

Epidemiological evaluation in Spain is centered on understanding disease burden, strengthening diagnostic practices, and improving recognition of cardiac amyloidosis across healthcare settings.

United Kingdom

The epidemiological landscape in the United Kingdom is supported by ongoing efforts to enhance disease awareness, improve diagnostic accuracy, and evaluate the burden of cardiac amyloidosis within the healthcare system.

Japan

Epidemiological research in Japan focuses on strengthening disease surveillance, improving diagnostic identification, and evaluating the clinical burden of cardiac amyloidosis to support effective patient management.

India

Cardiac involvement represents a significant manifestation among patients with amyloidosis in India. According to Sumeet Mirgh et al., 2025, cardiac involvement was reported in approximately 40%–50% of patients with amyloidosis. The study also noted that Indian patients presented at a median age of 50 years, with 70% of cases occurring in men, although these findings refer to the broader amyloidosis population rather than exclusively to cardiac amyloidosis.

Key Market Gaps, Untapped Opportunities, and Emerging Growth Areas in the Regional Disease Epidemiology Landscape

Despite increasing awareness, cardiac amyloidosis remains substantially underdiagnosed across many regions because its symptoms often resemble those of other cardiovascular disorders. Limited access to advanced diagnostic imaging, genetic testing, and specialized referral centers further delays diagnosis, particularly in developing healthcare systems. Significant opportunities exist to expand screening programs for high-risk populations, improve physician awareness, and enhance access to disease-specific diagnostic technologies. Continued adoption of precision diagnostics and broader availability of targeted therapies are expected to strengthen epidemiological assessment and improve patient identification across regional healthcare markets.

Cardiac Amyloidosis: Treatment Overview

Cardiac amyloidosis treatment depends on the underlying amyloid subtype and disease severity. For ATTR-CM, transthyretin stabilizers, gene-silencing therapies, and supportive cardiovascular care are the primary treatment approaches. AL amyloidosis is managed with plasma cell-directed therapies, including chemotherapy and, in selected patients, autologous stem cell transplantation. Standard heart failure medications are used cautiously because of altered hemodynamics in these patients. Advances in targeted therapy have significantly improved disease management by slowing amyloid deposition, preserving cardiac function, and enhancing survival in appropriately diagnosed individuals.

Key Questions Answered

  • What is the current and projected burden of cardiac amyloidosis across the 8 major markets?
  • Which countries across the 8 major markets account for the highest cardiac amyloidosis patient populations and fastest growth rates?
  • What is the diagnosed versus undiagnosed patient population of cardiac amyloidosis across key countries in the 8 major markets?
  • Which countries demonstrate the largest gaps in screening, early diagnosis, and disease awareness of cardiac amyloidosis across the 8 major markets?
  • What are the major drivers contributing to the increasing burden of cardiac amyloidosis across the 8 major markets?
  • How do major comorbidities and risk factors influence cardiac amyloidosis epidemiology trends across the 8 major markets?
  • What are the regional trends in advanced disease progression, treatment uptake, and patient management of cardiac amyloidosis across the 8 major markets?
  • Which patient segments represent the highest unmet clinical need in the cardiac amyloidosis landscape across the 8 major markets?
  • Which therapeutic areas linked to cardiac amyloidosis are expected to witness the strongest growth opportunities across the 8 major markets?
  • How is the cardiac amyloidosis epidemiology landscape expected to evolve over the next 5 to 10 years across the 8 major markets?
  • Which countries across the 8 major markets offer the most attractive market opportunities based on cardiac amyloidosis epidemiology and healthcare infrastructure?
  • Which epidemiological trends are expected to influence future drug development and market access strategies for cardiac amyloidosis across the 8 major markets?

Scope of the Cardiac Amyloidosis Epidemiology Report

  • The report covers a detailed analysis of signs and symptoms, causes, risk factors, pathophysiology, diagnosis, treatment options, and classification/types of cardiac amyloidosis based on several factors.
  • Cardiac Amyloidosis Epidemiology Forecast Report covers data for the eight major markets (the US, France, Germany, Italy, Spain, the UK, Japan, and India).
  • The cardiac amyloidosis report helps to identify the patient population, and the unmet needs are highlighted along with an assessment of the disease's risk and burden.

Related Reports

Cardiac Amyloidosis Pipeline Analysis Report

Amyloidosis Market

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Report Features

Details

Base Year

2025

Historical Period

2019-2025

Forecast Period

2026-2035

Epidemiology Statistics Provided

  • Diagnosed Prevalent Cases
  • Type-Specific Cases
  • Gender-Specific Cases
  • Age-Specific Cases

Segmentation Provided

  • Epidemiology by Age Group
  • Epidemiology by Gender
  • Epidemiology by Type of Disease
  • Epidemiology by Region

Geographies Covered

  • United States
  • Germany
  • Italy
  • France
  • Spain
  • United Kingdom
  • Japan
  • India

Datasheet

10 % Off

USD

2,699

2,429

Single User License

10 % Off

USD

4,299

3,869

Five User License

15 % Off

USD

5,799

4,949

Corporate License

15 % Off

USD

6,999

5,949

Datasheet

One User

USD 2,699

USD 2,429

tax inclusive*

  • Selected Segments
  • Printing Restrictions
  • Excel Spreadsheet Delivered via Email
  • Full Report
  • Periodic Updates
  • Post Sales Analysts Support
  • Unlimited Prints

Single User License

One User

USD 4,299

USD 3,869

tax inclusive*

  • All Segments
  • Printing Restrictions
  • PDF Delivered via Email
  • Custom Report Layout
  • Post Sales Analysts Support
  • Periodic Updates
  • Unlimited Prints

Five User License

Five User

USD 5,799

USD 4,949

tax inclusive*

  • All Segments
  • Five Prints Available
  • PDF Delivered via Email
  • Limited Free Customization
  • Post Sales Analyst Support
  • Custom Report Layout
  • Periodic Updates
  • Unlimited Prints

Corporate License

Unlimited Users

USD 6,999

USD 5,949

tax inclusive*

  • All Segments
  • Unlimited Prints Available
  • PDF & Excel Delivery via Email
  • Limited Free Customization
  • Post Sales Analysts Support
  • Discount On Next Update
  • Custom Report Layout

*Please note that the prices mentioned below are starting prices for each bundle type. Kindly contact our team for further details.*

Bundle Type

Flash Bundle

20% OFF Number of Reports: 3

Small Business Bundle

25% OFF Number of Reports: 5

Growth Bundle

30% OFF Number of Reports: 8

Enterprise Bundle

35% OFF Number of Reports: 10
Overview
  • Life Time Access
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours
  • Complimentary Free 1 Month Subscription to Trade Data Base
  • Complimentary One Month Subscription to Price Database (Chemicals only)
  • Complimentary PPT Version of the Report
  • Complimentary License Upgrade
  • Complimentary Power BI Dashboards
  • Life Time Access
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours - 50 Hours
  • Complimentary Free 1 Month Subscription to Trade Data Base
  • Complimentary One Month Subscription to Price Database (Chemicals only)
  • Complimentary PPT Version of the Report
  • Complimentary License Upgrade
  • Complimentary Power BI Dashboards
  • Life Time Access
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours - 80 Hours
  • Complimentary Free 1 Month Subscription to Trade Data Base
  • Complimentary One Month Subscription to Price Database (Chemicals only)
  • Complimentary PPT Version of the Report
  • Complimentary License Upgrade
  • Complimentary Power BI Dashboards
  • Life Time Access
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours - 100 Hours
  • Complimentary Free 1 Month Subscription to Trade Data Base
  • Complimentary One Month Subscription to Price Database (Chemicals only)
  • Complimentary PPT Version of the Report
  • Complimentary License Upgrade
  • Complimentary Power BI Dashboards

*Please note that the prices mentioned below are starting prices for each bundle type. Kindly contact our team for further details.*

Flash Bundle

Number of Reports: 3

20%

tax inclusive*

  • 3 Reports Included
  • Life Time Acess
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Free 1 Month Subscription to Trade Data Base
  • 1 Month Subscription to Price Database (Chemicals only)
  • Complimentary Excel Data Set
  • PPT Version of the Report
  • Power BI Dashboards
  • License Upgrade
  • Free Analyst Hours

Small Business Bundle

Number of Reports: 5

25%

tax inclusive*

  • 5 Reports Included
  • Life Time Acess
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours - 50 Hours
  • Free 1 Month Subscription to Trade Data Base
  • 1 Month Subscription to Price Database (Chemicals only)
  • Complimentary Excel Data Set
  • PPT Version of the Report
  • Power BI Dashboards
  • License Upgrade

Growth Bundle

Number of Reports: 8

30%

tax inclusive*

  • 8 Reports Included
  • Life Time Acess
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours - 50 Hours
  • Free 1 Month Subscription to Trade Data Base
  • 1 Month Subscription to Price Database (Chemicals only)
  • License Upgrade
  • Free Analyst Hours - 80 Hours
  • Power BI Dashboards

Enterprise Bundle

Number of Reports: 10

35%

tax inclusive*

  • 10 Reports Included
  • Life Time Acess
  • Analyst Support Related to Report
  • PDF Version of the Report
  • Complimentary Excel Data Set
  • Free Analyst Hours - 50 Hours
  • Free 1 Month Subscription to Trade Data Base
  • 1 Month Subscription to Price Database (Chemicals only)
  • License Upgrade
  • Power BI Dashboards
  • Free Analyst Hours - 100 Hours

How To Order

This is a collaborative report by Vishakha Agrawal reflecting perspectives and research-driven insights from Expert Market Research.

Our step-by-step guide will help you select, purchase, and access your reports swiftly, ensuring you get the information that drives your decisions, right when you need it.

License Type

Select License Type

Choose the right license for your needs and access rights.

shopping cart

Click on ‘Buy Now’

Add the report to your cart with one click and proceed to register.

Bookmark Icon

Select Mode of Payment

Choose a payment option for a secure checkout. You will be redirected accordingly.

Strategic Solutions for Informed Decision-Making

Connect For More Information

Our expert team of analysts will offer full support and resolve any queries regarding the report, before and after the purchase.

Our expert team of analysts will offer full support and resolve any queries regarding the report, before and after the purchase.

We employ meticulous research methods, blending advanced analytics and expert insights to deliver accurate, actionable industry intelligence, staying ahead of competitors.

Our skilled analysts offer unparalleled competitive advantage with detailed insights on current and emerging markets, ensuring your strategic edge.

We offer an in-depth yet simplified presentation of industry insights and analysis to meet your specific requirements effectively.

We’re here to help answer any questions about our products and services.

Contact us