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Cardiac amyloidosis is a progressive disorder caused by the deposition of misfolded amyloid proteins within the heart, leading to impaired cardiac function and heart failure. According to Rare Disease Advisor, cardiac amyloidosis is present in approximately 10% of patients with heart failure worldwide, with wild-type transthyretin-mediated amyloid cardiomyopathy accounting for most cases. According to the cardiac amyloidosis epidemiology forecast by Expert Market Research, the rising disease burden is expected to support increased diagnosis and treatment demand.
Base Year
Historical Period
Forecast Period

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Expert Market Research's “Cardiac Amyloidosis Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of cardiac amyloidosis. It projects the future incidence and prevalence rates of cardiac amyloidosis cases across various populations. The study covers age, gender, and type as major determinants of the cardiac amyloidosis population. The report highlights patterns in the prevalence of cardiac amyloidosis over time and projects future trends based on multiple variables.
The report provides a comprehensive overview of the disease, as well as historical and projected data on the epidemiology of cardiac amyloidosis in the 8 major markets.
Regions Covered
Cardiac amyloidosis is a progressive disorder characterized by the deposition of misfolded amyloid proteins within the heart muscle, leading to increased ventricular stiffness, impaired cardiac function, and ultimately heart failure if left untreated. The condition develops when abnormal proteins accumulate in the extracellular space, disrupting normal myocardial structure and function. The two primary types are transthyretin amyloid cardiomyopathy (ATTR-CM), which includes hereditary and wild-type forms, and immunoglobulin light-chain amyloidosis (AL amyloidosis). Early recognition using multimodal imaging and clinical assessment is essential for improving diagnosis, disease management, and long-term patient outcomes.
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Parameter |
Insight |
|
Largest Patient Pool |
United States |
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Fastest Growing Region |
India |
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High-Risk Population |
Older adults, particularly individuals aged 65 years and above, and patients with hereditary transthyretin gene mutations. |
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Key Diagnostic Method |
Echocardiography combined with cardiac magnetic resonance imaging and nuclear scintigraphy. |
|
Major Risk Factor |
Aging and transthyretin protein instability or plasma cell dyscrasia. |
|
Major gap in the market |
Underdiagnosis due to nonspecific symptoms and delayed recognition in routine clinical practice. |
The cardiac amyloidosis epidemiology division offers information on the patient pool from history to the present as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the cardiac amyloidosis epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for cardiac amyloidosis and their trends. The data is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.
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Epidemiology Segment |
Key Insights |
|
Diagnosed Prevalent Cases of the Disease |
Cardiac amyloidosis is increasingly recognized because of advances in diagnostic techniques and greater disease awareness. According to Rare Disease Advisor, cardiac amyloidosis is present in approximately 10% of patients with heart failure worldwide, with wild-type transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) accounting for the majority of cases. As reported by Jonathan D. Knott et al., 2025, the overall prevalence of cardiac amyloidosis among adults undergoing transthoracic echocardiography in the United States was 1.25%, including 0.76% ATTR and 0.47% AL cardiac amyloidosis. |
|
Gender-Specific Cases of the Disease |
Cardiac amyloidosis demonstrates distinct gender-related differences in disease recognition and diagnosis. As per Julia Vogel et al., 2025, women represented 14.2% of 240 patients diagnosed with ATTR-CM, while men accounted for the majority of cases. The median diagnostic delay was significantly longer in women (750 vs. 86 days), highlighting potential underdiagnosis in female patients. |
|
Age-Specific Cases of the Disease |
The prevalence of cardiac amyloidosis increases substantially with advancing age. According to Jonathan D. Knott et al., 2025, prevalence increased from 0.14% in individuals younger than 50 years to 2.30% among those aged 80–89 years, the highest reported age group. ATTR cardiac amyloidosis peaked in patients aged 80–89 years, whereas AL cardiac amyloidosis was most common in those aged 60–69 years. |
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Ethnicity-Wise Cases of the Disease |
The epidemiology of cardiac amyloidosis may vary across different ethnic populations because of differences in genetic predisposition, disease subtype distribution, healthcare accessibility, and diagnostic practices. Understanding ethnicity-based patterns can support earlier diagnosis, appropriate disease management, and improved epidemiological assessment across diverse populations. |
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Mortality and Survival Analysis of the Disease |
Cardiac amyloidosis continues to be associated with considerable mortality despite improvements in diagnosis. According to Abdalhakim Shubietah et al., 2025, the age-adjusted mortality rate increased from 0.261 in 1999 to 0.608 in 2020, representing an average annual increase of 3.96%. As per Svenja Ney et al., 2023, the median survival following diagnosis in Germany was 2.5 years, with a 9% reduction in mortality risk during the latter half of the study period. |
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Disease Type |
Prevalence |
|
ATTR Cardiac Amyloidosis |
As reported by Jonathan D. Knott et al., 2025, ATTR cardiac amyloidosis had a prevalence of 0.76% among adults undergoing transthoracic echocardiography in the United States. According to Rare Disease Advisor, wild-type ATTR-CM accounts for the majority of cardiac amyloidosis cases globally. |
|
AL Cardiac Amyloidosis |
According to Jonathan D. Knott et al., 2025, AL cardiac amyloidosis accounted for 0.47% of the evaluated U.S. cohort and was less prevalent than ATTR cardiac amyloidosis within the study population. |

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The cardiac amyloidosis epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.
|
Country |
Key Insights |
|
United States |
Cardiac amyloidosis is being increasingly identified through enhanced diagnostic evaluation. As reported by Jonathan D. Knott et al., 2025, the prevalence among adults undergoing transthoracic echocardiography was 1.25%, including 0.76% ATTR and 0.47% AL cardiac amyloidosis. According to Rare Disease Advisor, cardiac amyloidosis is present in approximately 10% of patients with heart failure worldwide, with ATTR-CM representing the predominant subtype. |
|
Germany |
The epidemiological burden of cardiac amyloidosis has increased over time with improved disease recognition. As per Svenja Ney et al., 2023, prevalence increased from 15.5 to 47.6 per 100,000 person-years, while incidence rose from 4.8 to 11.6 per 100,000 person-years between 2009 and 2018. The study also reported a median survival of 2.5 years following diagnosis. |
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France |
Epidemiological assessment of cardiac amyloidosis in France focuses on improving disease recognition, early diagnosis, and evaluation of the affected patient population to better understand the national disease burden. |
|
Italy |
Epidemiological studies in Italy primarily emphasize the identification of affected patients, assessment of disease burden, and enhancement of diagnostic approaches to support timely detection and management of cardiac amyloidosis. |
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Spain |
Epidemiological evaluation in Spain is centered on understanding disease burden, strengthening diagnostic practices, and improving recognition of cardiac amyloidosis across healthcare settings. |
|
United Kingdom |
The epidemiological landscape in the United Kingdom is supported by ongoing efforts to enhance disease awareness, improve diagnostic accuracy, and evaluate the burden of cardiac amyloidosis within the healthcare system. |
|
Japan |
Epidemiological research in Japan focuses on strengthening disease surveillance, improving diagnostic identification, and evaluating the clinical burden of cardiac amyloidosis to support effective patient management. |
|
India |
Cardiac involvement represents a significant manifestation among patients with amyloidosis in India. According to Sumeet Mirgh et al., 2025, cardiac involvement was reported in approximately 40%–50% of patients with amyloidosis. The study also noted that Indian patients presented at a median age of 50 years, with 70% of cases occurring in men, although these findings refer to the broader amyloidosis population rather than exclusively to cardiac amyloidosis. |
Despite increasing awareness, cardiac amyloidosis remains substantially underdiagnosed across many regions because its symptoms often resemble those of other cardiovascular disorders. Limited access to advanced diagnostic imaging, genetic testing, and specialized referral centers further delays diagnosis, particularly in developing healthcare systems. Significant opportunities exist to expand screening programs for high-risk populations, improve physician awareness, and enhance access to disease-specific diagnostic technologies. Continued adoption of precision diagnostics and broader availability of targeted therapies are expected to strengthen epidemiological assessment and improve patient identification across regional healthcare markets.
Cardiac amyloidosis treatment depends on the underlying amyloid subtype and disease severity. For ATTR-CM, transthyretin stabilizers, gene-silencing therapies, and supportive cardiovascular care are the primary treatment approaches. AL amyloidosis is managed with plasma cell-directed therapies, including chemotherapy and, in selected patients, autologous stem cell transplantation. Standard heart failure medications are used cautiously because of altered hemodynamics in these patients. Advances in targeted therapy have significantly improved disease management by slowing amyloid deposition, preserving cardiac function, and enhancing survival in appropriately diagnosed individuals.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.
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Report Features |
Details |
|
Base Year |
2025 |
|
Historical Period |
2019-2025 |
|
Forecast Period |
2026-2035 |
|
Epidemiology Statistics Provided |
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Segmentation Provided |
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Geographies Covered |
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