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Report Overview

Syphilis is a curable bacterial sexually transmitted infection caused by Treponema pallidum. As per Yanhui Huang et al. (2025), approximately 12 million new cases occur globally each year, with 90% reported in developing countries. According to syphilis epidemiology forecast by Expert Market Research, disease burden remains an important public health concern.

2025

Base Year

2019-2025

Historical Period

2026-2035

Forecast Period

Syphilis – Number of Cases by Year

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Syphilis Epidemiology Forecast Report Coverage

Expert Market Research's “Syphilis Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of syphilis. It projects the future incidence and prevalence rates of syphilis cases across various populations. The study covers age, gender, and type as major determinants of the syphilis population. The report highlights patterns in the prevalence of syphilis over time and projects future trends based on multiple variables.

The report provides a comprehensive overview of the disease, as well as historical and projected data on the epidemiology of syphilis in the 8 major markets.

Regions Covered

  • United States
  • Germany
  • France
  • Italy
  • Spain
  • United Kingdom
  • Japan
  • India

Syphilis Understanding: Disease Overview

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. It spreads primarily through direct contact with infectious sores during sexual activity and can also be transmitted from an infected pregnant person to the fetus. The disease progresses through four stages: primary, secondary, latent, and tertiary syphilis, each characterized by distinct clinical manifestations. If left untreated, syphilis can cause severe cardiovascular and neurological complications. Sexually transmitted infections (STIs) remain an important public health concern because early-stage syphilis may be overlooked or misdiagnosed.

Key Report Insights

Parameter

Insight

Largest Patient Pool

United States

Fastest Growing Country

India

High-Risk Population

Men who have sex with men, people with multiple or new sexual partners, and pregnant individuals with untreated syphilis are important priority populations

Key Diagnostic Method

Serologic testing

Major Risk Factor

Sexual contact with an infected person, particularly without consistent condom use, increases transmission risk

Major gap in the market

Underdiagnosis and delayed treatment

Syphilis Epidemiology Perspective

The syphilis epidemiology division offers information on the patient pool from history to the present as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the syphilis epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for syphilis and their trends. The data is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

Epidemiology Segment

Key Insights

Diagnosed Prevalent Cases of the Disease

According to Yanhui Huang et al. (2025), approximately 12 million new syphilis cases occur globally each year, with 90% occurring in developing countries. An estimated 4 million adults aged 15-49 years were infected in 2022.

Gender-Specific Cases of the Disease

As per the European Centre for Disease Prevention and Control, the male-to-female ratio for syphilis cases in 2023 was 7.4:1, with 35,962 cases among men and 4,841 among women, corresponding to rates of 17.6 and 2.4 per 100,000, respectively.

Age-Specific Cases of the Disease

According to the UK Health Security Agency (2025), individuals aged 25-34 years accounted for 35% of infectious syphilis diagnoses in England in 2024, representing 3,311 of 9,535 cases. European surveillance also identifies women aged 20-34 years as a significant group for monitoring.

Ethnicity-Wise Cases of the Disease

Syphilis surveillance can support assessments of differences in disease burden across population groups. Evaluating these patterns alongside access to testing, diagnosis, and treatment can help identify populations requiring targeted prevention and public health interventions.

Mortality and Survival Analysis of the Disease

Monitoring syphilis-associated mortality requires consideration of disease stage, congenital infections, and complications. Timely diagnosis and treatment are important public health priorities, particularly for preventing adverse pregnancy outcomes and reducing the burden of congenital syphilis.

Type-Specific Disease Burden and Epidemiology Analysis

Disease Type

Prevalence

Primary syphilis

An early stage of syphilis and a major category in disease surveillance, characterized by the initial stage of infection.

Secondary syphilis

An early stage of syphilis that follows primary syphilis and represents another important category of reported infections.

Latent syphilis

A stage in which visible symptoms are absent. It is classified as early latent or late latent syphilis based on the duration of infection.

Tertiary syphilis

A late-stage form of syphilis that can develop years after the initial infection and may cause severe complications affecting multiple organs.

Congenital syphilis

A form of syphilis transmitted from an infected mother to her baby during pregnancy, representing an important category for maternal and child health surveillance.

Syphilis – Number of Cases by Country

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Country-wise Syphilis Epidemiology

The syphilis epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.

Country

Key Insights

United States

According to Infectious Disease Advisor, syphilis rates in the United States increased from 39.6 per 100,000 population in 2019 to 62.5 per 100,000 in 2023. A total of 209,253 cases, including congenital syphilis, were reported in 2023, representing the highest annual total since 1950.

Germany

According to Beacon, Germany reported 9,519 syphilis cases in 2024, the highest number since notifications began. European surveillance data from the European Centre for Disease Prevention and Control also identified Germany among the countries with male syphilis notification rates of at least 20 cases per 100,000 population in 2023.

France

According to the European Centre for Disease Prevention and Control, syphilis surveillance in Europe identified substantial gender differences in 2023, with the overall male-to-female ratio reaching 7.4:1. These regional findings provide context for monitoring syphilis epidemiology in France and evaluating differences in reported infections by sex.

Italy

According to Valentina Marchese et al. (2022), Italy's estimated syphilis notification rate was 2.5 per 100,000 population, with a male-to-female ratio of 7:1 in 2018. National data from 1991-2017 indicated that men accounted for 91% of primary and secondary syphilis cases and 65% of latent cases.

Spain

According to the European Centre for Disease Prevention and Control, Spain was among the European countries reporting syphilis rates of at least 20 cases per 100,000 men in 2023. Science Media Centre also reported that Spain ranked second highest for syphilis rates in Europe in its discussion of 2024 surveillance findings.

United Kingdom

According to the UK Health Security Agency (2025), England recorded 9,535 infectious syphilis diagnoses in 2024, an increase of 1.7% from 9,375 in 2023. Individuals aged 25-34 years accounted for 35% of diagnoses, while gay and bisexual men accounted for 66%.

Japan

According to Yanhui Huang et al. (2025), Japan recorded 14,906 syphilis cases in 2023 and 10,162 new cases by September 15, 2024. Akira Komori et al. (2024) reported a 36.0% increase in cases in Japan in 2021 and a 66.2% increase in 2022, indicating a post-pandemic resurgence.

India

According to the Indian Journal of Pathology and Oncology (2024), syphilis seroprevalence among blood donors in India ranges from 0.03% to 2.6% across different states. These findings illustrate regional variation in reported seropositivity, although blood donor estimates should not be interpreted as representative of prevalence in the general population.

Key Market Gaps, Untapped Opportunities, and Emerging Growth Areas in the Regional Disease Epidemiology Landscape

Syphilis management across the United States, Germany, France, Italy, Spain, the United Kingdom, Japan, and India presents opportunities to strengthen early diagnosis, screening coverage, and timely antibiotic treatment. A major unmet need is the identification of asymptomatic infections through accessible testing services, particularly among populations at increased risk and during pregnancy. Congenital syphilis prevention also requires consistent prenatal screening, timely treatment, and follow-up. Expanding rapid diagnostic testing, improving partner notification, and strengthening surveillance systems could support earlier intervention, reduce transmission, and improve epidemiological monitoring across these markets.

Syphilis: Treatment Overview

Syphilis is treated primarily with penicillin G, with the formulation and treatment duration determined by the disease stage and clinical circumstances. Benzathine penicillin G is the preferred treatment for most patients with early syphilis, while neurosyphilis requires an appropriate intravenous penicillin regimen. Pregnant patients with syphilis should receive penicillin according to clinical guidelines to prevent congenital infection. Patients with penicillin allergies may require alternative management, although penicillin remains essential during pregnancy. Antibiotic therapy can cure the infection, but it cannot reverse all damage caused by advanced disease. Follow-up serologic testing is necessary to assess treatment response, and sexual partners should be evaluated and treated when indicated.

Key Questions Answered

  • What is the current and projected burden of Syphilis across the 8 major markets?
  • Which countries across the 8 major markets account for the highest Syphilis patient populations and fastest growth rates?
  • What is the diagnosed versus undiagnosed patient population of Syphilis across key countries in the 8 major markets?
  • Which countries demonstrate the largest gaps in screening, early diagnosis, and disease awareness of Syphilis across the 8 major markets?
  • What are the major drivers contributing to the increasing burden of Syphilis across the 8 major markets?
  • How do major comorbidities and risk factors influence Syphilis epidemiology trends across the 8 major markets?
  • What are the regional trends in advanced disease progression, treatment uptake, and patient management of Syphilis across the 8 major markets?
  • Which patient segments represent the highest unmet clinical need in the Syphilis landscape across the 8 major markets?
  • Which therapeutic areas linked to Syphilis are expected to witness the strongest growth opportunities across the 8 major markets?
  • How is the Syphilis epidemiology landscape expected to evolve over the next 5 to 10 years across the 8 major markets?
  • Which countries across the 8 major markets offer the most attractive market opportunities based on Syphilis epidemiology and healthcare infrastructure?
  • Which epidemiological trends are expected to influence future drug development and market access strategies for Syphilis across the 8 major markets?

Scope of the Syphilis Epidemiology Report

  • The report covers a detailed analysis of signs and symptoms, causes, risk factors, pathophysiology, diagnosis, treatment options, and classification/types of Syphilis based on several factors.
  • Syphilis Epidemiology Forecast Report covers data for the eight major markets (the US, France, Germany, Italy, Spain, the UK, Japan, and India).
  • The Syphilis report helps to identify the patient population, and the unmet needs are highlighted along with an assessment of the disease's risk and burden.

Related Reports

Syphilis Immunoassay Diagnostics Market

Sexually Transmitted Diseases Testing Market

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

Report Summary

Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Report Features

Details

Base Year

2025

Historical Period

2019-2025

Forecast Period

2026-2035

Epidemiology Statistics Provided

  • Diagnosed Prevalent Cases
  • Type-Specific Cases
  • Gender-Specific Cases
  • Age-Specific Cases

Segmentation Provided

  • Epidemiology by Age Group
  • Epidemiology by Gender
  • Epidemiology by Type of Disease
  • Epidemiology by Region

Geographies Covered

  • United States
  • Germany
  • Italy
  • France
  • Spain
  • United Kingdom
  • Japan
  • India

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