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The wet macular degeneration market attained a value of USD 10.09 Billion in 2025, driven by the rising aging population and advancements in treatment options across the 8 major markets. It is expected to grow at a CAGR of 5.90% in the forecast period of 2026-2035, and attain a value of USD 17.90 Billion by 2035.
Geopolitical Impact of Iran, US, and Israel War on the Wet Macular Degeneration Market
United States: The Wet Macular Degeneration Market, a key segment of the global economy, is experiencing a complex operating environment in Q1 2026 as a direct consequence of the US-Israel-Iran war. Petrochemical-derived pharmaceutical packaging materials including blister packs, polymer bottles, and specialty film coatings are facing 15-20% cost inflation from the Gulf supply disruption. API production costs are rising as petrochemical reagent prices increase 15-20%. Air freight costs have spiked dramatically, with temperature-sensitive pharmaceutical distribution facing elevated costs and extended lead times as Gulf carrier networks remain suspended. Consumer spending caution is growing as gasoline above USD 4 per gallon and 4.2% projected inflation compress household discretionary budgets. Clinical trial operations in Middle Eastern investigator sites have been disrupted, and medical supply chains face elevated logistics costs.
Iran: Iran's healthcare system has been severely damaged by the conflict, with the WHO identifying at least 13 health facilities as conflict-damaged. The domestic pharmaceutical and medical device sector, already severely constrained by sanctions limiting access to Western medical technology and APIs, has been further disrupted by power outages, workforce displacement, and the collapse of medical supply chain logistics. Iranian patients requiring treatment for wet macular degeneration conditions face an acute access crisis, as hospital operations are redirected toward treating conflict casualties and basic medical supplies are running low.
Israel: Israel's pharmaceutical and medical device sector is operating under emergency conditions. Israeli hospitals have moved some operations underground, medical resources are being prioritised for conflict casualties, and elective and non-emergency healthcare consumption has declined. However, Israel's biopharmaceutical research base continues to operate, with several Israeli companies involved in novel treatment development for wet macular degeneration indications. Post-conflict, Israel's healthcare system is expected to invest significantly in medical technology and pharmaceutical infrastructure restoration and capacity expansion.
Government
Market
Procurement
Base Year
Historical Period
Forecast Period
Progress in anti-VEGF treatments, such as ranibizumab and aflibercept, alongside developments like gene therapies and long-acting treatments, are increasing treatment choices and driving market growth.
In September 2024, the FDA approved Pavblu as the fifth biosimilar referencing Eylea. The acceptance of numerous biosimilars enhances competition, leading to market expansion by enhancing accessibility and affordability of treatment.
The United States is expected to dominate the market, driven by its sophisticated healthcare system, large aging population, and significant investment in research and advanced treatment options.
Compound Annual Growth Rate
5.9%
Value in USD Billion
2026-2035
*this image is indicative*
Wet macular degeneration (or neovascular AMD) is a long-term disease that affects central vision in senior citizens. Wet macular degeneration is a more serious condition and is a type of AMD marked by a severe, rapid loss of central vision in the retina where macular degeneration has occurred. This condition develops when the small blood vessels beneath the macula of the retina swarm and ooze out fluids like blood. While the rest of the retina is involved in the peripheral vision, the macula is responsible for the central vision, necessary for reading or identifying faces. Symptoms are effectively controlled by early intervention, and medications like anti-VEGF injections can delay the progression of the condition.
Increasing Aging Population to Boost the Market Growth
In a report, the World Health Organization (WHO) highlighted that with increasing life expectancy, a large number of individuals will reach 60 or older by 2050. Wet macular degeneration cases are bound to surge with the increasing incidence of the geriatric population base, leading to increased demand for treatment among the elderly with vision-related diseases.
FDA Approval Boosts the Market Growth
In September 2024, Pavblu, the fifth biosimilar referencing Eylea (aflibercept), was approved by the FDA for the treatment of retinal conditions such as wet age-related macular degeneration. Pavblu, developed by Amgen, was approved after a phase 3 study with 576 patients from various countries. It is one of several biosimilars that got approval in 2024, along with Yesafili, Opuviz, Ahzantive, and Enzeevu. There is a growing emphasis on early detection and preventive healthcare. Increasing approvals from essential regulatory authorities is expected to boost the market value in the forecast period.
The market is witnessing several trends and developments to improve the current scenario. Some of the notable trends are as follows:
The report offers a detailed analysis of the market based on the following segments:
Market Breakup by Disease Stage
Market Breakup by Treatment Type
Market Breakup by Route of Administration
Market Breakup by End User
Market Breakup by Region
Market Segmentation Based on the Route of Administration Set to Witness Substantial Growth
The market is segmented into intravenous route and intravitreal route based on the route of administration. Among these, the intravitreal method is expected to dominate the market because it directly administers drugs into the eye, resulting in improved treatment results and fewer overall side effects. Medications such as Ranibizumab (Lucentis) and Aflibercept (Eylea) are often given through injections directly into the eye. This technique enables focused treatment of the retina, effectively preventing the growth of abnormal blood vessels. Due to its established efficacy and lower risks when compared to systemic delivery, intravitreal therapy continues to be considered the preferred treatment method for wet AMD.
Segmentation Based on End User Holds a Significant Market Share
The market is divided into hospitals, clinics, ambulatory surgical centers, homecare settings, and others. Among these, hospitals and clinics are expected to dominate the market because of their specialized ophthalmologists and advanced diagnostic equipment. They provide thorough treatment, which includes giving anti-VEGF medications such as Lucentis and Eylea via injections into the eye. Ambulatory surgical centers also hold a substantial share due to their affordability, while homecare settings are utilized for remote monitoring and occasional medical care.
Based on region, the market report covers the United States, EU-4, and the United Kingdom (Germany, France, Italy, Spain, United Kingdom), Japan, and India. Due to advanced healthcare systems and substantial investment in research, the United States is expected to dominate the market. Factors like increasing elderly populations and lifestyle-related risks impact the market in this area. The government's backing promotes market expansion through leadership in clinical trials and innovative treatments such as targeted therapies and immunotherapies. The market is growing due to greater emphasis on early detection and personalized treatment choices.
The key features of the market report include patent analysis, clinical trials analysis, grants analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies are:
Bayer AG, headquartered in Leverkusen, Germany, is a leading pharmaceutical company in the age-related wet macular degeneration (AMD) market. Their primary product, Eylea (aflibercept), is a very effective treatment for wet AMD that can preserve and even improve vision. Bayer remains committed to investing in the research and development of new AMD therapies.
Established in 1896 and headquartered in Basel, Switzerland. Roche specializes in ophthalmic disorder drugs. They developed Lucentis, a popular anti-VEGF therapy drug for wet AMD, through Genentech. They are working on new delivery methods and long-acting formulations to reduce reliance on frequent injections in AMD treatment, leveraging their biopharmaceutical expertise.
Pfizer Inc. is a significant player in the wet age-related macular degeneration (AMD) market, which is highly competitive and poised for growth due to the aging global population and the rising prevalence of eye disorders.
Novartis AG is a leading player in the market, primarily through its flagship drug, Lucentis (ranibizumab), a pioneering anti-VEGF therapy developed in partnership with Genentech.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
Other companies include Panoptica Pharma, Bausch + Lomb, Regeneron Pharmaceuticals Inc., Ocugen Inc., REGENXBIO Inc., and Oxurion NV, among others.
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
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| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Disease Stage |
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| Breakup by Treatment Type |
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| Breakup by Route of Administration |
|
| Breakup by End User |
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| Breakup by Region |
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| Market Dynamics |
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| Supplier Landscape |
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| Companies Covered |
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