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Report Overview

Myelodysplastic syndrome (MDS) is a group of bone marrow disorders characterized by ineffective blood cell production and an increased risk of progression to acute myeloid leukemia. As per the American Cancer Society, approximately 10,000 people are diagnosed with MDS annually in the United States, although estimates vary. According to the Myelodysplastic syndrome epidemiology forecast by Expert Market Research, disease burden trends support continued attention to hematologic malignancies.

2025

Base Year

2019-2025

Historical Period

2026-2035

Forecast Period

Myelodysplastic Syndrome – Number of Cases by Year

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Myelodysplastic Syndrome Epidemiology Forecast Report Coverage

Expert Market Research's “Myelodysplastic Syndrome Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of myelodysplastic syndrome. It projects the future incidence and prevalence rates of myelodysplastic syndrome cases across various populations. The study covers age, gender, and type as major determinants of the myelodysplastic syndrome population. The report highlights patterns in the prevalence of myelodysplastic syndrome over time and projects future trends based on multiple variables.

The report provides a comprehensive overview of the disease, as well as historical and projected data on the epidemiology of myelodysplastic Syndrome in the 8 major markets.

Regions Covered

  • United States
  • Germany
  • France
  • Italy
  • Spain
  • United Kingdom
  • Japan
  • India

Myelodysplastic Syndrome Understanding: Disease Overview

Myelodysplastic syndromes (MDS) are a group of clonal bone marrow disorders characterized by ineffective blood cell production, abnormal blood cell development, and persistent cytopenias. The disease develops when acquired genetic alterations in hematopoietic stem cells disrupt normal blood cell formation, resulting in reduced levels of red blood cells, white blood cells, or platelets. MDS primarily affects older adults and carries a variable risk of progression to acute myeloid leukemia. Classification considers factors such as genetic abnormalities, bone marrow findings, and blast cell counts, reflecting the disease's hematologic malignancy characteristics.

Key Report Insights

Parameter

Insight

Largest Patient Pool

United States

Fastest Growing Country

India

High-Risk Population

Older adults, particularly those aged 65 years and older, and individuals previously treated with chemotherapy or radiation therapy.

Key Diagnostic Method

Complete blood count, peripheral blood smear, bone marrow aspiration and biopsy, and cytogenetic or molecular testing to confirm and classify MDS.

Major Risk Factor

Advanced age; previous chemotherapy or radiation therapy and exposure to certain chemicals, including benzene, are also associated with increased risk.

Major gap in the market

Delayed recognition of unexplained cytopenias, together with the need for comprehensive bone marrow, cytogenetic, and molecular evaluation to support accurate diagnosis and risk classification.

Myelodysplastic Syndrome Epidemiology Perspective

The myelodysplastic syndrome epidemiology division offers information on the patient pool from history to the present as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the myelodysplastic syndrome epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for myelodysplastic syndrome and their trends. The data is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

Epidemiology Segment

Key Insights

Diagnosed Prevalent Cases of the Disease

According to the American Cancer Society, annual MDS diagnoses in the United States have been estimated at approximately 10,000, although estimates vary. Cancer Council Victoria reported 440 diagnoses in Victoria in 2024, highlighting the documented disease burden.

Gender-Specific Cases of the Disease

As per Cancer Council Victoria, 281 males and 159 females were diagnosed with MDS in Victoria in 2024, representing 64% and 36% of cases, respectively. According to HealthTree Foundation, males accounted for approximately 56% of cases in a 2000-2021 analysis.

Age-Specific Cases of the Disease

According to the American Cancer Society, MDS is uncommon before age 50 and is most frequently diagnosed in people in their 70s. Universitätsklinikum Ulm reports an average diagnosis age of approximately 75 years in Germany.

Ethnicity-Wise Cases of the Disease

According to HealthTree Foundation, an analysis of more than 84,000 patients diagnosed between 2000 and 2021 examined differences in outcomes by race, income, and geographic location. These factors provide context for assessing disparities in MDS outcomes.

Mortality and Survival Analysis of the Disease

According to Cancer Council Victoria, MDS accounted for 1.5% of cancer-related deaths in Victoria in 2024. HealthTree Foundation reported lower five-year survival among males and poorer outcomes among rural residents and people with lower household incomes.

Type-Specific Disease Burden and Epidemiology Analysis

Disease Type

Prevalence

MDS with low blasts and isolated 5q deletion (MDS-5q)

MDS with low blasts represents a clinically important category of myelodysplastic syndromes. Its relative contribution to the overall disease burden may vary across populations, depending on diagnostic classification and patient characteristics.

MDS with low blasts and SF3B1 mutation (MDS-SF3B1)

MDS with increased blasts is an important disease category associated with a higher blast count. Its representation within the overall MDS population may vary according to the distribution of disease subtypes and diagnostic criteria.

MDS with biallelic TP53 inactivation (MDS-biTP53)

This genetically defined subtype represents a distinct category of MDS. Its relative frequency may vary across patient populations according to the genetic characteristics of diagnosed cases.

Myelodysplastic Syndrome – Number of Cases by Country

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Country-wise Myelodysplastic Syndrome Epidemiology

The myelodysplastic syndrome epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.

Country

Key Insights

United States

According to the American Cancer Society, annual MDS diagnoses in the United States have been estimated at approximately 10,000, although estimates vary. MDS is uncommon before age 50 and is most frequently diagnosed in people in their 70s.

Germany

According to Universitätsklinikum Ulm, MDS incidence in Germany is approximately 4 cases per 100,000 inhabitants, and the average age at diagnosis is around 75 years.

France

As per Paris Saint-Louis Leukemia Institute, approximately 4,000 MDS cases are diagnosed annually in France. The disease mainly affects older adults and is more common in males than females.

Italy

In Italy, population aging and the identification of MDS among older adults are relevant considerations when assessing the disease burden. Differences in diagnostic recognition and the completeness of case registration may also affect estimates of reported incidence.

Spain

According to MD Anderson, approximately 3,000 new MDS cases are diagnosed annually in Spain. Around 90% of patients are older than 60 years, and 10%-20% of diagnosed cases progress to acute myeloid leukemia.

United Kingdom

In the United Kingdom, age distribution is an important consideration in assessing MDS epidemiology. Recognition of cases in older adults and the accuracy of cancer registration are relevant to understanding the reported disease burden.

Japan

According to Shuji Uno et al. (2023), MDS incidence in Japan increases with age, particularly among individuals aged 70 years or older. The estimated median age at diagnosis is 76 years.

India

In India, access to specialized hematology services, the availability of diagnostic testing, and recognition of MDS may influence the number of cases identified. These factors are relevant when assessing the disease burden across different healthcare settings.

Key Market Gaps, Untapped Opportunities, and Emerging Growth Areas in the Regional Disease Epidemiology Landscape

Myelodysplastic syndrome presents opportunities to improve early diagnosis, molecular characterization, and access to risk-appropriate treatment across the United States, Germany, France, Italy, Spain, the United Kingdom, Japan, and India. Because the disease predominantly affects older adults, aging populations may increase the need for diagnostic evaluation and long-term disease management. A major unmet need is effective treatment for higher-risk patients who do not respond to hypomethylating agents. Advances in molecular risk stratification and emerging therapies may support more personalized treatment, while improved diagnostic capacity could help address under-recognition.

Myelodysplastic Syndrome: Treatment Overview

Myelodysplastic syndromes treatment depends on disease risk, genetic characteristics, blood cell counts, symptoms, age, and overall health. Supportive care may include red blood cell or platelet transfusions, iron chelation when indicated, and growth factors to manage cytopenias. Disease-modifying treatments include hypomethylating agents, such as azacitidine and decitabine, while selected patients may receive lenalidomide or other targeted approaches based on disease features. Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for eligible patients. These approaches aim to improve blood counts, reduce transfusion requirements, and delay disease progression through risk-adapted therapy.

Key Questions Answered

  • What is the current and projected burden of myelodysplastic syndrome across the 8 major markets?
  • Which countries across the 8 major markets account for the highest myelodysplastic syndrome patient populations and fastest growth rates?
  • What is the diagnosed versus undiagnosed patient population of myelodysplastic syndrome across key countries in the 8 major markets?
  • Which countries demonstrate the largest gaps in screening, early diagnosis, and disease awareness of myelodysplastic syndrome across the 8 major markets?
  • What are the major drivers contributing to the increasing burden of myelodysplastic syndrome across the 8 major markets?
  • How do major comorbidities and risk factors influence myelodysplastic syndrome epidemiology trends across the 8 major markets?
  • What are the regional trends in advanced disease progression, treatment uptake, and patient management of myelodysplastic syndrome across the 8 major markets?
  • Which patient segments represent the highest unmet clinical need in the myelodysplastic syndrome landscape across the 8 major markets?
  • Which therapeutic areas linked to myelodysplastic syndrome are expected to witness the strongest growth opportunities across the 8 major markets?
  • How is the myelodysplastic syndrome epidemiology landscape expected to evolve over the next 5 to 10 years across the 8 major markets?
  • Which countries across the 8 major markets offer the most attractive market opportunities based on myelodysplastic syndrome epidemiology and healthcare infrastructure?
  • Which epidemiological trends are expected to influence future drug development and market access strategies for myelodysplastic syndrome across the 8 major markets?

Scope of the Myelodysplastic Syndrome Epidemiology Report

  • The report covers a detailed analysis of signs and symptoms, causes, risk factors, pathophysiology, diagnosis, treatment options, and classification/types of myelodysplastic syndrome based on several factors.
  • Myelodysplastic Syndrome Epidemiology Forecast Report covers data for the eight major markets (the US, France, Germany, Italy, Spain, the UK, Japan, and India).
  • The myelodysplastic syndrome report helps to identify the patient population, and the unmet needs are highlighted along with an assessment of the disease's risk and burden.

Related Reports

Myelodysplastic Syndrome Pipeline Analysis

Relapsed or Refractory Myelodysplastic Syndrome Pipeline Analysis

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.

Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Report Features

Details

Base Year

2025

Historical Period

2019-2025

Forecast Period

2026-2035

Epidemiology Statistics Provided

  • Diagnosed Prevalent Cases
  • Type-Specific Cases
  • Gender-Specific Cases
  • Age-Specific Cases

Segmentation Provided

  • Epidemiology by Age Group
  • Epidemiology by Gender
  • Epidemiology by Type of Disease
  • Epidemiology by Region

Geographies Covered

  • United States
  • Germany
  • Italy
  • France
  • Spain
  • United Kingdom
  • Japan
  • India

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