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Report Overview

Peripheral artery disease (PAD) is a cardiovascular disease characterized by narrowed arteries that reduce blood flow, primarily to the limbs. As per the American College of Cardiology Foundation, PAD represents a significant global health burden, affecting millions worldwide. According to the peripheral artery disease epidemiology overview by Expert Market Research, the disease remains an important area of epidemiological assessment.

2025

Base Year

2019-2025

Historical Period

2026-2035

Forecast Period

Peripheral Artery Disease – Number of Cases by Year

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Peripheral Artery Disease Epidemiology Forecast Report Coverage

Expert Market Research's “Peripheral Artery Disease Epidemiology Forecast Report 2026-2035” offers comprehensive information on the prevalence and demographics of peripheral artery disease. It projects the future incidence and prevalence rates of peripheral artery disease cases across various populations. The study covers age, gender, and type as major determinants of the peripheral artery disease population. The report highlights patterns in the prevalence of peripheral artery disease over time and projects future trends based on multiple variables.

The report provides a comprehensive overview of the disease, as well as historical and projected data on the epidemiology of peripheral artery disease in the 8 major markets.

Regions Covered

  • United States
  • Germany
  • France
  • Italy
  • Spain
  • United Kingdom
  • Japan
  • India

Peripheral Artery Disease Understanding: Disease Overview

Peripheral artery disease (PAD) is a circulatory condition characterized by the narrowing or blockage of arteries that supply blood to the limbs, most commonly the legs. It primarily develops due to atherosclerosis, in which fatty deposits accumulate within arterial walls, restricting blood flow and oxygen delivery to tissues. Common symptoms include leg pain during walking, numbness, and slow-healing wounds, although some patients remain asymptomatic. PAD may present as asymptomatic disease, symptomatic disease with intermittent claudication, or chronic limb-threatening ischemia. Atherosclerotic cardiovascular disease is a relevant associated condition because PAD shares several underlying vascular risk factors.

Key Report Insights

Parameter

Insight

Largest Patient Pool

India

Fastest Growing Country

India

High-Risk Population

Older adults, current and former smokers, and individuals with diabetes, hypertension, or dyslipidemia

Key Diagnostic Method

Ankle-brachial index (ABI), which compares blood pressure at the ankle and arm to help identify reduced blood flow

Major Risk Factor

Tobacco smoking, which contributes to atherosclerosis and increases the risk of PAD and related cardiovascular complications

Major gap in the market

Underdiagnosis, limited screening of high-risk populations, and unequal access to vascular specialists and revascularization services

Peripheral Artery Disease Epidemiology Perspective

The peripheral artery disease epidemiology division offers information on the patient pool from history to the present as well as the projected trend for each of the 8 major markets. Expert Market Research provides both current and predicted trends for the peripheral artery disease epidemiology scenario by examining a wide range of studies. Additionally, the report covers the diagnosed patient pool for peripheral artery disease and their trends. The data is broken down into specific categories, such as total prevalent cases in males and females, and total diagnosed cases across different age groups and patient pools.

Epidemiology Segment

Key Insights

Diagnosed Prevalent Cases of the Disease

According to Matthew A. Allison et al. (2023), peripheral artery disease (PAD) affects approximately 200 million people worldwide, including an estimated 7-12 million people in the United States. Asymptomatic cases contribute to underdiagnosis and may result in prevalence estimates that underestimate the overall disease burden.

Gender-Specific Cases of the Disease

As per the Australian Institute of Health and Welfare, PAD-related hospitalizations in Australia during 2023-24 were 1.9 times higher among males than females after age adjustment. In 2024, PAD death rates were 1.6 times higher among males than females.

Age-Specific Cases of the Disease

According to Matthew A. Allison et al. (2023), PAD prevalence increases rapidly with age and is highest among adults older than 70 years. In Australia, hospitalizations and deaths also increase with age, with the highest rates observed among people aged 85 years and older.

Ethnicity-Wise Cases of the Disease

As reported by Matthew A. Allison et al. (2023), Black Americans experience a disproportionately high burden of PAD. Among men aged 50-59 years, prevalence was approximately 5%, compared with 1.9% among non-Hispanic White individuals of the same age.

Mortality and Survival Analysis of the Disease

According to the Australian Institute of Health and Welfare, PAD was the underlying cause of 1,900 deaths in Australia in 2024, representing 1.0% of all deaths. The burden was concentrated among older adults, with 74% of PAD deaths occurring in people aged 75 years and older.

Type-Specific Disease Burden and Epidemiology Analysis

Disease Type

Prevalence

Lower-extremity PAD

Lower-extremity PAD is the most common form of peripheral artery disease and affects blood flow to the legs and feet, contributing to the overall burden of PAD.

Upper-extremity PAD

Upper-extremity PAD affects blood flow to the arms, hands, and fingers and is considerably less common than lower-extremity PAD.

Peripheral Artery Disease – Number of Cases by Country

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Country-wise Peripheral Artery Disease Epidemiology

The peripheral artery disease epidemiology data and findings for the United States, Germany, Spain, Italy, France, the United Kingdom, Japan, and India are also provided in the epidemiology section.

Country

Key Insights

United States

According to Matthew A. Allison et al. (2023), an estimated 7-12 million people in the United States have PAD. Prevalence increases with age and differs across sex, racial, and ethnic groups.

Germany

As reported by Alexandros Giosdekos et al. (2025), PAD prevalence increases from approximately 3% in middle age to more than 18% among men aged 70-75 years.

France

PAD contributes to the broader European disease burden. According to Alexandros Giosdekos et al. (2025), approximately 40 million people in Europe live with PAD, although a France-specific prevalence estimate was not provided.

Italy

According to Alexandros Giosdekos et al. (2025), PAD prevalence in Italy is approximately 22.9%, highlighting a substantial burden compared with several other European countries.

Spain

The prevalence of peripheral artery disease in Spain is influenced by population aging and the increasing burden of cardiovascular risk factors, including diabetes, smoking, hypertension, dyslipidemia, and obesity. These factors contribute to atherosclerosis and increase the risk of PAD, particularly among older adults and individuals with multiple underlying risk factors.

United Kingdom

According to Alexandros Giosdekos et al. (2025), approximately 20% of individuals older than 60 years in the United Kingdom have PAD.

Japan

As reported by Nobuko Hayashi et al. (2022), a study in rural Hokkaido found PAD prevalence of 1.6% among males and 0.7% among females younger than 60 years in Japan. Among people aged 60 years and older, prevalence was 3.6% among males and 3.3% among females.

India

According to Ajay Yadav et al. (2024), PAD affects approximately 12% of the adult population in India, with the burden increasing alongside global prevalence trends.

Key Market Gaps, Untapped Opportunities, and Emerging Growth Areas in the Regional Disease Epidemiology Landscape

Underdiagnosis and unequal access to early diagnosis remain important challenges across the United States, Germany, France, Italy, Spain, the United Kingdom, Japan, and India. Opportunities include improving ankle-brachial index testing among high-risk individuals, particularly older adults and people with diabetes or a history of smoking. India may offer substantial opportunities to expand PAD awareness, diagnostic capacity, and access to evidence-based treatment. Across these markets, greater use of structured exercise programs, cardiovascular risk management, and timely revascularization may help address unmet clinical needs and reduce the risk of limb complications.

Peripheral Artery Disease: Treatment Overview

Peripheral artery disease treatment focuses on improving blood flow, reducing cardiovascular risks, relieving symptoms, and preventing limb complications. Management typically includes smoking cessation, structured exercise therapy, and dietary and lifestyle modifications. Medications such as antiplatelet agents, statins, and selected drugs for intermittent claudication may be prescribed according to individual clinical needs. For patients with severe symptoms or chronic limb-threatening ischemia, revascularization procedures, including endovascular angioplasty with or without stenting and surgical bypass, may be necessary. Endovascular revascularization is an important treatment approach that can restore blood flow in selected patients and help reduce the risk of limb loss.

Key Questions Answered

  • What is the current and projected burden of Peripheral Artery Disease across the 8 major markets?
  • Which countries across the 8 major markets account for the highest Peripheral Artery Disease patient populations and fastest growth rates?
  • What is the diagnosed versus undiagnosed patient population of Peripheral Artery Disease across key countries in the 8 major markets?
  • Which countries demonstrate the largest gaps in screening, early diagnosis, and disease awareness of Peripheral Artery Disease across the 8 major markets?
  • What are the major drivers contributing to the increasing burden of Peripheral Artery Disease across the 8 major markets?
  • How do major comorbidities and risk factors influence Peripheral Artery Disease epidemiology trends across the 8 major markets?
  • What are the regional trends in advanced disease progression, treatment uptake, and patient management of Peripheral Artery Disease across the 8 major markets?
  • Which patient segments represent the highest unmet clinical need in the Peripheral Artery Disease landscape across the 8 major markets?
  • Which therapeutic areas linked to Peripheral Artery Disease are expected to witness the strongest growth opportunities across the 8 major markets?
  • How is the Peripheral Artery Disease epidemiology landscape expected to evolve over the next 5 to 10 years across the 8 major markets?
  • Which countries across the 8 major markets offer the most attractive market opportunities based on Peripheral Artery Disease epidemiology and healthcare infrastructure?
  • Which epidemiological trends are expected to influence future drug development and market access strategies for Peripheral Artery Disease across the 8 major markets?

Scope of the Peripheral Artery Disease Epidemiology Report

  • The report covers a detailed analysis of signs and symptoms, causes, risk factors, pathophysiology, diagnosis, treatment options, and classification/types of Peripheral Artery Disease based on several factors.
  • Peripheral Artery Disease Epidemiology Forecast Report covers data for the eight major markets (the US, France, Germany, Italy, Spain, the UK, Japan, and India).
  • The Peripheral Artery Disease report helps to identify the patient population, and the unmet needs are highlighted along with an assessment of the disease's risk and burden.

Related Reports

Peripheral Artery Disease Market

Peripheral Artery Disease Pipeline Analysis

*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*

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Key Highlights of the Report

Please note that the figures mentioned in the description serve as estimates and may vary from the actual figures presented in the final report.

Report Features

Details

Base Year

2025

Historical Period

2019-2025

Forecast Period

2026-2035

Epidemiology Statistics Provided

  • Diagnosed Prevalent Cases
  • Type-Specific Cases
  • Gender-Specific Cases
  • Age-Specific Cases

Segmentation Provided

  • Epidemiology by Age Group
  • Epidemiology by Gender
  • Epidemiology by Type of Disease
  • Epidemiology by Region

Geographies Covered

  • United States
  • Germany
  • Italy
  • France
  • Spain
  • United Kingdom
  • Japan
  • India

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