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Over the last decade, the domain of epigenomics has witnessed the invention and application of a large number of new-generation sequencing methods examining different aspects of chromatin biology, such as histone modification state, DNA methylation, and 3D structure. Thousands of epigenome maps from hundreds of human tissues and cell types have been produced. The integration of these data enables the prediction of enhancers and promoters, and monitoring of their activity with several other functional aspects of the epigenome. Continual development of more sensitive epigenomic approaches, such as ATAC-seq and ChIPmentation, and single-cell methods combined with (epi)genetic editing methods such as CRISPR/Cas9 are expected to enable more powerful analyses of chromatin states and associated regulatory networks. North America, Europe and Asia are expected to be key markets.
Several leading companies are engaged in epigenomics. For example, Epigenomics AG is engaged in cancer diagnostics through its unique, proprietary DNA methylation biomarker technology. The company develops and commercializes patient-friendly, blood-based diagnostic tests across multiple cancer indications with high medical need. Using blood as a liquid biopsy could enhance patient access to cancer screening and contribute to eradicating today’s deadliest cancer types, such as colorectal, liver, and lung cancer. Products on the market include Epi proColon® and Epi BiSKit; such products are expected to boost the global epigenomics market.
Illumina offers a wide portfolio of next-generation sequencing (NGS)- and array-based epigenetic analysis tools that offer robust, simple-to-use, and cost-efficient solutions for studying epigenetic modifications and their impact on gene regulation. The company works with leading epigenomics experts to ensure that its solutions meet the field's rapidly evolving needs.
Existing technologies have shown that epigenetic modifications in particular genes mediate normal development and a host of disease processes, including congenital or inherited disorders, such as epilepsy and Rett syndrome, and several forms of cancer. Novel technologies enabling further research on the genomic scale are expected to offer additional information on the intricacies and significance of epigenetic changes, and provide new and deeper insights into epigenetic contributions to disease processes. Such information could be used towards the development of new diagnostic tools and treatment strategies, which, in turn, would more likely boost the global epigenomics market.
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