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Cystic Fibrosis Treatment Market

Global Cystic Fibrosis Treatment Market Size, Growth, Trends, Report: By Treatment Methods: Medications, Devices; By Drug Class: Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Others; By Drug Molecule Type; By Route of Administration; By Treatment Channel; By Distribution Channel; Regional Analysis; Supplier Landscape; 2024-2032

Global Cystic Fibrosis Treatment Market Outlook

The global market value in 2023 was USD 9.41 billion, driven by the increasing prevalence of the disease and the introduction of new therapies across the globe. The global cystic fibrosis market size is anticipated to grow at a CAGR of 13.4% during the forecast period of 2024-2032 to achieve a value of USD 29.19 billion by 2032.

 

cystic fibrosis treatment market

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Cystic Fibrosis Insights

Cystic fibrosis (CF) is an inherited disease that causes severe damage to the lungs, digestive system, and other body organs. Cystic fibrosis affects the cells responsible for the production of mucus, sweat, and digestive juices. Normally, these secreted fluids are thin and slippery, however, in people with cystic fibrosis, a faulty gene causes the secretions to become sticky and thick.  These secretions, rather than acting as lubricants, clog tubes, ducts, and passageways, particularly in the lungs and pancreas. 

 

Despite the fact that cystic fibrosis is a progressive disease that necessitates daily care, people with CF are usually able to do all the daily activities. Patients suffering from CF now have a better quality of life than previous generations of CF patients. Due to the advancements in screening and treatment, people with CF can now live in their mid- to late-30s or 40s, with some even living into their 50s. 

 

The signs and symptoms in the respiratory and digestive systems include:

  • A chronic cough that produces thick mucus (sputum)
  • Wheezing
  • Intolerance to Exercise
  • Recurring Lung Infections
  • Inflammation of the Nasal Passages or a Stuffy Nose
  • Sinusitis that Recurs

 

The thick mucus can also obstruct the tubes that transport digestive enzymes from the pancreas to the small intestine. Without these digestive enzymes, the intestines are unable to absorb all of the nutrients in the food consumed. It often results in:

  • Smelly and Greasy Stools
  • Inadequate Weight Gain and Growth
  • Intestinal Obstruction, especially in New-Borns
  • Constipation that is chronic or severe, with frequent straining to pass stool, eventually causing part of the rectum to protrude outside the anus.

 

CF is caused by a mutation in the "cystic fibrosis transmembrane conductance regulator" gene, or CFTR gene. Gene regulates the movement of water and salt into and out of the cells. A sudden mutation or change in the CFTR gene causes the mucus to thicken and stickier than usual. This abnormal mucus raises the salt content of the sweat and accumulates in various organs throughout the body, including the intestines, pancreas, liver, and lungs.

 

According to the cystic fibrosis treatment market research report, the market can be categorized into the following segments: 

 

cystic fibrosis treatment market by segments

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Market Breakup by Treatment Method

  • Drug Treatment
  • Airway Clearance Technique
  • Pulmonary Rehabilitation
  • Surgical Methods
    • Nasal and Sinus Surgery
    • Bowel Surgery
    • Lung Transplant
    • Liver Transplant
  • Others

 

Market Breakup by Drug Class

  • Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators
  • Bronchodilators
  • Mucolytics
  • Pancreatic Enzyme Supplement
  • Others

 

Market Breakup by Route of Administration

  • Oral Drug
  • Inhaled Drug

 

Market Breakup by Distribution Channel

  • Hospital Based Pharmacies
  • Online Pharmacies
  • Retail Pharmacies

 

Market Breakup by Region

  • North America
    • United States of America
    • Canada
  • Europe
    • United Kingdom
    • Germany
    • France
    • Italy
    • Others
  • Asia Pacific
    • China
    • Japan
    • India
    • ASEAN
    • Australia
    • Others
  • Latin America
    • Brazil
    • Argentina
    • Mexico
    • Others
  • Middle East and Africa
    • Saudi Arabia
    • United Arab Emirates
    • Nigeria
    • South Africa
    • Others

 

cystic fibrosis treatment market by region

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Cystic Fibrosis Therapeutic Landscape

According to the Cystic Fibrosis Foundation, over 30,000 people in the United States have cystic fibrosis, and an additional 1,000 are diagnosed each year. Since CF is a progressive disease, it worsens over time and thus the treatment is extremely crucial. 

 

Although there is no cure for CF, there are several treatments that can help relieve the symptoms and reduce the risk of complications. The available treatments include antibiotics, mucus-thinning medication, NSAIDs, Bronchodilators, CFTR, whereas the surgical procedures include bowel surgery, feeding tube, and double lung transplant. Other than medications and surgical treatment, chest physical therapy and home care are also included in the management of this disease.

 

Drivers and Constraints

The market growth has been aided by an increase in the number of cystic fibrosis patients worldwide. Cystic fibrosis pharmacotherapy has resulted in a number of advancements in the treatment of this ailment, which is positively impacting the market growth. 

 

Cystic fibrosis treatment market growth is expected to be driven by the rise in non-profit initiatives, increase in government-backed legislation, and increases in research and development funding.  Researchers are expected to increase their investment in research and development activities in order to fuel market growth. There are a number of drugs in development, including Symdeko, VX-561, ELX-02, and ABBV-3067.

 

In terms of region, the global market is expected to be dominated by North America. The dominance can be attributed to the rapid increase in cystic fibrosis cases in the region, an increase in patients with various respiratory diseases affecting cystic fibrosis, and higher healthcare costs. 

 

Europe is in the second position, following North America in terms of demand for advanced drugs due to the prevalence of the disease and the increased use of advanced drugs to achieve better results. 

 

On the other hand, there are some factors which have been restricting the growth of the market. Along with the positive effects these medicines provide, there are some side effects that come with these medicines. These undesirable side effects include upper respiratory tract infections, liver problems, chest pain, and an increase in blood pressure, among other issues, and may obstruct the growth of the treatment market.

 

Clinical Trial

In the past few years, it has been observed that patients with cystic fibrosis have been able to live longer due to the rapid improvements in clinical care. There are some European countries where life expectancy has increased to 30-40 years. 

 

The growth of the cystic fibrosis treatment market is driven by the treatment of lung diseases and improved nutrition. The current treatment strategies can be improved by identifying new effective agents. Various clinical trials are underway for several drugs that are suspected of being effective in combating CFTR dysfunction. Cystic fibrosis is a condition that affects many organs. 

 

The development of drugs to treat lung disease, dyspepsia, and pancreatic malabsorption has become increasingly important. Researchers are developing drugs in many fields, including anti-inflammatory treatments, ion channel blockers, and genetic therapies. 

 

A major objective of pancreatic insufficiency treatment is to develop pancreatic enzymes that work most efficiently. A variety of treatments for cystic fibrosis are driving the growth of the cystic fibrosis treatment market. 

 

  • Treatment with nebulized antibiotics for chronic lung disease reduces lung damage and improves lung function.
  • There is a reduction in exacerbations and improved quality of life in a randomized controlled trial of azithromycin FEV1 treatment.
  • The use of Ursodeoxycholic acid (URSO) in patients has been shown to normalize liver enzyme levels.
  • Several clinical trials have been conducted to restore CFTR function in patients suffering from disease. Transient and moderate effects of gene transfer were observed on CFTR function. There have been improvements to gene transfer agents and plasmids, and clinical trials will commence shortly.

 

The cystic fibrosis treatment market is experiencing rapid growth due to an increasing demand for research.

 

Competitive Landscape

The report gives an in-depth analysis of the key players involved in the global cystic fibrosis treatment market, sponsors manufacturing the drugs, and putting them through trials to get FDA approvals. The companies included in the market are as follows: 

 

  • Genentech, Inc.
  • Gilead Sciences, Inc.
  • Novartis International AG
  • Vertex Pharmaceuticals Incorporated
  • Johnson & Johnson Services, Inc
  • Allergan Plc.
  • Nestle Health Science S.A.
  • AbbVie Inc.
  • Horizon Therapeutics Plc.
  • Chiesi Farmaceutici S.P.A.
  • Pharmaxis Ltd.
  • Teva Pharmaceuticals Industries Ltd

 

Key Highlights of the Report

REPORT FEATURES DETAILS
Base Year 2023
Historical Period 2017-2023
Forecast Period 2024-2032
Scope of the Report

Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:

  • Treatment Methods
  • Drug Class
  • Drug Molecule Type
  • Route of Administration
  • Treatment Channel
  • Distribution Channel
  • Region
Breakup by Treatment Methods
  • Medications
  • Devices
Breakup by Drug Class
  • Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
  • Bronchodilators
  • Mucolytic
  • Pancreatic Enzyme Supplement
  • Others
Breakup by Drug Molecule Type
  • Small Molecules
  • Biologics
Breakup by Route of Administration
  • Oral
  • Parentals
  • Others
Breakup by Treatment Channel
  • Public
  • Private
Breakup by Distribution Channel
  • Hospital Pharmacy
  • Retail Pharmacy
  • Online Pharmacy
  • Others
Breakup by Region
  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East and Africa
Market Dynamics
  • Market Drivers and Constraints
  • SWOT Analysis
  • Porter’s Five Forces Model 
  • Key Demand Indicators
  • Key Price Indicators
  • Industry Events, Initiatives, and Trends 
  • Value Chain Analysis
Supplier Landscape
  • Market Structure
  • Company Profiles
    • Company Overview
    • Product Portfolio
    • Demographic Reach and Achievements
    • Merger and Acquisitions
    • Certifications
Companies Covered
  • AbbVie Inc.
  • Allergan
  • Chiesi Farmaceutici SpA
  • F. Hoffmann-La Roche Ltd.
  • Gilead Sciences
  • Novartis AG
  • Pharmaxis Ltd.
  • PTC Therapeutics
  • Vertex Pharmaceuticals
  • Demegen, Inc.
  • Mor Research Applications
  • Alaxia
  • Alcresta Therapeutics, Inc.
  • AstraZeneca
  • Genentech, Inc.
  • Pfizer Inc.
  • Mylan N.V.
  • Alcresta Therapeutics, Inc.
  • Teva Pharmaceutical Industries Ltd
  • Bayer AG

 

*At Expert Market Research, we strive to always give you current and accurate information. The numbers depicted in the description are indicative and may differ from the actual numbers in the final EMR report.

1    Preface
    1.1    Objectives of the Study
    1.2    Key Assumptions
    1.3    Report Coverage – Key Segmentation and Scope 
    1.4    Research Methodology
2    Executive Summary
3    Cystic Fibrosis Disease Overview 

    3.1    Guidelines and Stages
    3.2    Pathophysiology
    3.3    Screening and Diagnosis
    3.4    Treatment Pathway 
4    Patient Profile
    4.1    Patient Profile Overview
    4.2    Patient Psychology and Emotional Impact Factors
    4.3    Risk Assessment and Treatment Success Rate
5    Cystic Fibrosis Epidemiology Analysis
    5.1    Epidemiology Overview (2016-2031)
    5.2    North America Cystic Fibrosis Epidemiology (2016-2031)
    5.3    Europe Cystic Fibrosis Epidemiology (2016-2031)
    5.4    Asia-Pacific Cystic Fibrosis Epidemiology (2016-2031)
    5.5    Latin America Cystic Fibrosis Epidemiology (2016-2031)
    5.6    Middle East & Africa Cystic Fibrosis Epidemiology (2016-2031)
6    Global Cystic Fibrosis Market Overview 
    6.1    Global Cystic Fibrosis Market Historical Value (2017-2023) 
    6.2    Global Cystic Fibrosis Market Forecast Value (2024-2032)
7    Global Cystic Fibrosis Market Landscape
    7.1    Cystic Fibrosis: Developers Landscape
        7.1.1    Analysis by Year of Establishment
        7.1.2    Analysis by Company Size
        7.1.3    Analysis by Region
    7.2    Cystic Fibrosis: Product Landscape
        7.2.1    Analysis by Treatment Methods
        7.2.2    Analysis by Drug Class
        7.2.3    Analysis by Molecule Type
        7.2.4    Analysis by Route of Administration
        7.2.5    Analysis by Distribution Channel
8    Cystic Fibrosis Challenges and Unmet Needs
    8.1    Treatment Pathway Challenges
    8.2    Compliance and Drop-Out Analysis
    8.3    Awareness and Prevention Gaps
9    Cost of Treatment
10    Global Cystic Fibrosis Market Dynamics

    10.1    Market Drivers and Constraints
    10.2    SWOT Analysis
    10.3    Porter’s Five Forces Model
    10.4    Key Demand Indicators 
    10.5    Key Price Indicators
    10.6    Industry Events, Initiatives, and Trends  
    10.7    Value Chain Analysis
11    Global Cystic Fibrosis Market Segmentation
    11.1    Global Cystic Fibrosis Market by Treatment Methods
        11.1.1    Market Overview
        11.1.2    Medications
        11.1.3    Devices
    11.2    Global Cystic Fibrosis Market by Drug Class
        11.2.1    Market Overview
        11.2.2    Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
        11.2.3    Bronchodilators
        11.2.4    Mucolytic
        11.2.5    Pancreatic Enzyme Supplement
        11.2.6    Others
    11.3    Global Cystic Fibrosis Market by Drug Molecule Type
        11.3.1    Market Overview
        11.3.2    Small Molecules
        11.3.3    Biologics
    11.4    Global Cystic Fibrosis Market by Route of Administration
        11.4.1    Market Overview
        11.4.2    Oral 
        11.4.3    Parentals
        11.4.4    Others
    11.5    Global Cystic Fibrosis Market by Treatment Channel
        11.5.1    Market Overview
        11.5.2    Public
        11.5.3    Private
    11.6    Global Cystic Fibrosis Market by Distribution Channel
        11.6.1    Market Overview
        11.6.2    Hospital Pharmacy
        11.6.3    Retail Pharmacy
        11.6.4    Online Pharmacy
        11.6.5    Others
    11.7    Global Cystic Fibrosis Market by Region
        11.7.1    Market Overview
        11.7.2    North America
        11.7.3    Europe 
        11.7.4    Asia Pacific
        11.7.5    Latin America
        11.7.6    Middle East and Africa
12    North America Cystic Fibrosis Market
    12.1    Market Share by Country
    12.2    United States of America
    12.3    Canada
13    Europe Cystic Fibrosis Market
    13.1    Market Share by Country
    13.2    United Kingdom
    13.3    Germany
    13.4    France
    13.5    Italy
    13.6    Others
14    Asia Pacific Cystic Fibrosis Market
    14.1    Market Share by Country
    14.2    China
    14.3    Japan
    14.4    India
    14.5    ASEAN
    14.6    Australia
    14.7    Others
15    Latin America Cystic Fibrosis Market
    15.1    Market Share by Country
    15.2    Brazil
    15.3    Argentina
    15.4    Mexico
    15.5    Others
16    Middle East and Africa Cystic Fibrosis Market
    16.1    Market Share by Country
    16.2    Saudi Arabia
    16.3    United Arab Emirates
    16.4    Nigeria
    16.5    South Africa
    16.6    Others
17    Regulatory Framework
    17.1    Regulatory Overview
        17.1.1    US FDA
        17.1.2    EU EMA
        17.1.3    INDIA CDSCO
        17.1.4    JAPAN PMDA
        17.1.5    Others
18    Patent Analysis
    18.1    Analysis by Type of Patent
    18.2    Analysis by Publication year
    18.3    Analysis by Issuing Authority
    18.4    Analysis by Patent Age
    18.5    Analysis by CPC Analysis
    18.6    Analysis by Patent Valuation 
    18.7    Analysis by Key Players
19    Grants Analysis
    19.1    Analysis by year
    19.2    Analysis by Amount Awarded
    19.3    Analysis by Issuing Authority
    19.4    Analysis by Grant Application
    19.5    Analysis by Funding Institute
    19.6    Analysis by NIH Departments
    19.7    Analysis by Recipient Organization 
20    Clinical Trials Analysis
    20.1     Analysis by Trial Registration Year
    20.2    Analysis by Trial Status
    20.3    Analysis by Trial Phase
    20.4    Analysis by Therapeutic Area
    20.5    Analysis by Geography
21    Funding and Investment Analysis
    21.1    Analysis by Funding Instances
    21.2    Analysis by Type of Funding
    21.3    Analysis by Funding Amount
    21.4    Analysis by Leading Players
    21.5    Analysis by Leading Investors
    21.6    Analysis by Geography
22    Partnership and Collaborations Analysis
    22.1    Analysis by Partnership Instances
    22.2    Analysis by Type of Partnership
    22.3    Analysis by Leading Players
    22.4    Analysis by Geography
23    Supplier Landscape
    23.1    AbbVie Inc.
        23.1.1    Financial Analysis
        23.1.2    Product Portfolio
        23.1.3    Demographic Reach and Achievements
        23.1.4    Mergers and Acquisitions
        23.1.5    Certifications
    23.2    Allergan
        23.2.1    Financial Analysis
        23.2.2    Product Portfolio
        23.2.3    Demographic Reach and Achievements
        23.2.4    Mergers and Acquisitions
        23.2.5    Certifications
    23.3    Chiesi Farmaceutici SpA
        23.3.1    Financial Analysis
        23.3.2    Product Portfolio
        23.3.3    Demographic Reach and Achievements
        23.3.4    Mergers and Acquisitions
        23.3.5    Certifications
    23.4    F. Hoffmann-La Roche Ltd.
        23.4.1    Financial Analysis
        23.4.2    Product Portfolio
        23.4.3    Demographic Reach and Achievements
        23.4.4    Mergers and Acquisitions
        23.4.5    Certifications
    23.5    Gilead Sciences
        23.5.1    Financial Analysis
        23.5.2    Product Portfolio
        23.5.3    Demographic Reach and Achievements
        23.5.4    Mergers and Acquisitions
        23.5.5    Certifications
    23.6    Novartis AG
        23.6.1    Financial Analysis
        23.6.2    Product Portfolio
        23.6.3    Demographic Reach and Achievements
        23.6.4    Mergers and Acquisitions
        23.6.5    Certifications
    23.7    Pharmaxis Ltd.
        23.7.1    Financial Analysis
        23.7.2    Product Portfolio
        23.7.3    Demographic Reach and Achievements
        23.7.4    Mergers and Acquisitions
        23.7.5    Certifications
    23.8    PTC Therapeutics
        23.8.1    Financial Analysis
        23.8.2    Product Portfolio
        23.8.3    Demographic Reach and Achievements
        23.8.4    Mergers and Acquisitions
        23.8.5    Certifications
    23.9    Vertex Pharmaceuticals
        23.9.1    Financial Analysis
        23.9.2    Product Portfolio
        23.9.3    Demographic Reach and Achievements
        23.9.4    Mergers and Acquisitions
        23.9.5    Certifications
    23.10    Demegen, Inc.
        23.10.1    Financial Analysis
        23.10.2    Product Portfolio
        23.10.3    Demographic Reach and Achievements
        23.10.4    Mergers and Acquisitions
        23.10.5    Certifications
    23.11    Mor Research Applications
        23.11.1    Financial Analysis
        23.11.2    Product Portfolio
        23.11.3    Demographic Reach and Achievements
        23.11.4    Mergers and Acquisitions
        23.11.5    Certifications
    23.12    Alaxia
        23.12.1    Financial Analysis
        23.12.2    Product Portfolio
        23.12.3    Demographic Reach and Achievements
        23.12.4    Mergers and Acquisitions
        23.12.5    Certifications
    23.13    Alcresta Therapeutics, Inc.
        23.13.1    Financial Analysis
        23.13.2    Product Portfolio
        23.13.3    Demographic Reach and Achievements
        23.13.4    Mergers and Acquisitions
        23.13.5    Certifications
    23.14    AstraZeneca
        23.14.1    Financial Analysis
        23.14.2    Product Portfolio
        23.14.3    Demographic Reach and Achievements
        23.14.4    Mergers and Acquisitions
        23.14.5    Certifications
    23.15    Genentech, Inc.
        23.15.1    Financial Analysis
        23.15.2    Product Portfolio
        23.15.3    Demographic Reach and Achievements
        23.15.4    Mergers and Acquisitions
        23.15.5    Certifications
    23.16    Pfizer Inc.
        23.16.1    Financial Analysis
        23.16.2    Product Portfolio
        23.16.3    Demographic Reach and Achievements
        23.16.4    Mergers and Acquisitions
        23.16.5    Certifications
    23.17    Mylan N.V.
        23.17.1    Financial Analysis
        23.17.2    Product Portfolio
        23.17.3    Demographic Reach and Achievements
        23.17.4    Mergers and Acquisitions
        23.17.5    Certifications
    23.18    Alcresta Therapeutics, Inc.
        23.18.1    Financial Analysis
        23.18.2    Product Portfolio
        23.18.3    Demographic Reach and Achievements
        23.18.4    Mergers and Acquisitions
        23.18.5    Certifications
    23.19    Teva Pharmaceutical Industries Ltd
        23.19.1    Financial Analysis
        23.19.2    Product Portfolio
        23.19.3    Demographic Reach and Achievements
        23.19.4    Mergers and Acquisitions
        23.19.5    Certifications
    23.20    Bayer AG
        23.20.1    Financial Analysis
        23.20.2    Product Portfolio
        23.20.3    Demographic Reach and Achievements
        23.20.4    Mergers and Acquisitions
        23.20.5    Certifications
24    Cystic Fibrosis Market- Distribution Model (Additional Insight)
    24.1    Overview 
    24.2    Potential Distributors 
    24.3    Key Parameters for Distribution Partner Assessment 
25    Key Opinion Leaders (KOL) Insights (Additional Insight)
26    Company Competitiveness Analysis (Additional Insight)

    26.1    Very Small Companies
    26.2    Small Companies
    26.3    Mid-Sized Companies
    26.4    Large Companies
    26.5    Very Large Companies
27    Payment Methods (Additional Insight)
    27.1    Government Funded
    27.2    Private Insurance
    27.3    Out-of-Pocket

 

*Additional insights provided are customisable as per client requirements.

Key Questions Answered in the Report

Globally, Cystic Fibrosis market reached a value of USD 9.41 billion in 2023.

The market is projected to expand at a CAGR of 13.4% from 2024 to 2032, growing to USD 29.19 billion by 2032.

The major regions in the industry are North America, Latin America, the Middle East, Africa, Europe, and the Asia Pacific, with North America accounting for the largest share of the market.

Factors predicted to expand the market size  include the rising prevalence of genetic disorders worldwide which will expand the market of cystic fibrosis treatment.

Hospital is the end-user that is dominating the global market.

The key players in the market include Genentech, Inc., Gilead Sciences, Inc., Novartis International AG, Vertex Pharmaceuticals Incorporated, Johnson & Johnson Services, Inc, Allergan Plc., Nestle Health Science S.A., AbbVie Inc., Horizon Therapeutics Plc., Chiesi Farmaceutici S.P.A., Pharmaxis Ltd., and  Teva Pharmaceuticals Industries Ltd , among others.

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