Top Companies in the Global Cancer Cryotherapy Market in 2025

The global cancer cryotherapy market is expected to grow at a CAGR of 8.1% during the forecast period of 2025-2034, driven by the increasing incidence of multiple cancers and rapid advancements in cryotherapy equipment and techniques.

Cancer cryotherapy, or cryoablation, is a treatment that uses subzero temperatures to destroy cancer cells. A thin probe or cryoprobe is inserted into or around the tumor where it creates freezing temperatures to freeze and rupture the cancer cells. Such localized treatment avoids damaging nearby healthy tissue and is very effective for the minimally invasive approach of some tumors. It is most often used to treat small tumors or when they are in places that are difficult to reach by surgical means, such as the prostate, liver, and skin. It is often used as a standalone treatment, but it can also complement other therapies such as radiation or surgery. Patients often recover more quickly than with traditional surgical methods, making it a preferred choice for many.

The global market for cancer cryotherapy is growing significantly due to the increased demand for minimally invasive cancer treatments. Cryotherapy is receiving attention because of its specificity, shorter recovery periods, and ability to treat inaccessible tumors. Rapid advancements in technology, the increased effectiveness of the treatment, and the rising incidence of multiple cancers are driving the market growth. Additionally, increasing awareness among patients about alternative treatments and changing trends toward outpatient care propel the market forward. The market is also bolstered by increased investments and ongoing clinical trials, aiming to refine techniques.

In November 2024, the West Virginia University Cancer Institute pioneered the commercial use of Pentax Medical’s FDA-approved 180° C2 Cryoballoon, a breakthrough in minimally invasive cryotherapy. This innovation precisely targets abnormal esophageal cells, enhancing cancer prevention for Barrett’s esophagus patients. The rising adoption of such advanced cryotherapy techniques is driving significant growth in the cancer cryotherapy market.

Let’s explore the profile of top companies leading the global cancer cryotherapy market in 2025.

1.    Cooper Surgical, Inc.

CooperSurgical is a global leader in women’s healthcare, specializing in advanced medical devices and services for reproductive health and minimally invasive treatments. Among its innovations, the Leisegang ® Cryosurgery System LM-900 is a highlight in the cancer cryotherapy market. This advanced system is made to remove benign or pre-malignant lesions precisely by using controlled cryotherapy with CO2 or N2O, ensuring safety and effectiveness. The LM-900 showcases CooperSurgical's commitment to the advancement of patient care through innovative and reliable healthcare solutions.

2.    Zimmer MedizinSysteme GmbH

Zimmer MedizinSysteme is one of the well-known leaders in medical technology, particularly regarding cryotherapy applications for the treatment of cancer and well-being. The products provided by the company, such as Cryo  7, Cryo 6, and CryoMini, allow for very accurate cooling down to temperatures as low as -30°C. These products aid targeted therapies to be given to cancerous tissues, as well as to decrease inflammation. Thus, these cryotherapy applications are very supportive of patients who suffer from cancer. Zimmer's dedication to innovation and quality has established its products as highly respected both in medical clinics and in research facilities dedicated to oncology.

3.    Erbe Elektromedizin GmbH

Erbe is one of the most significant players in the global cancer cryotherapy market, which offers the most advanced cryosurgical solutions that have been used in medical practice for over two decades. Their ERBECRYO 2 system is a cryotherapy technology that exemplifies advanced cryotherapy technology, with an emphasis on consistent results in therapeutic applications, including oncology. The company's focus on innovation is also reflected in the variety of cryoprobes and accessories that support procedures like cryoextraction and cryodevitalization. They also provide robust support and education through the Erbe Academy, making sure medical professionals are well-equipped for optimal patient care.

4.    METRUM CRYOFLEX Sp. z o.o

Metrum Cryoflex is a leading European manufacturer specializing in advanced medical devices, including those for cryotherapy and cryosurgery. The company has nearly three decades of experience and is represented in more than 50 countries. They have significantly contributed to medical innovation. Their technology is advanced and designed to support effective, non-invasive treatments, particularly in areas like cancer therapy. Recent innovations in their cryosurgical  products have shown promise in these treatments as a targeted, less invasive alternative for patients. They have been committed to improving healthcare outcomes around the world.

5.    Brymill Cryogenic Systems UK Ltd

Brymill Cryogenic Systems UK Ltd is well-known in the global cancer cryotherapy market with its advanced handheld cryosurgical devices. Their devices work on liquid nitrogen (LN2) for the treatment of various types of skin diseases. These include skin cancers like basal cell carcinoma. Their product is known for safety, accuracy, and flexibility. Brymill's Cry-Ac series has become the must-have for dermatologists who need effective and controlled cryosurgery. The company's focus on innovation and quality has further established its leadership in cryotherapy solutions for skin lesions and cancer treatment.