Press Release

Amid Ukraine-Russia crisis, our analysts and industry experts are closely monitoring the markets and working hard to identify, gather and timely deliver analysis of the impact of the situation and the impact that it has on various markets. All our reports are updated with the latest impact on the market before being sent out to our customers.

Global Cancer Cachexia Market to Grow at a CAGR of 4.7% During the Period 2022-2027, Driven by Growing Incidences of Cachexia

According to a new report by EMR titled, ‘Global Cancer Cachexia Market Report and Forecast 2022-2027’, the global cancer cachexia market is expected to grow at a CAGR of 4.7% during the period 2022-2027, driven by advancements in treatment systems and rising cases of cachexia.

Cases of cachexia are increasing globally, and at present, the condition is estimated to affect nearly 1 percent of all patients. According to estimates, neatly 50 percent of all cancer patients eventually develop cachexia. Novel treatment approaches have been reported to deliver initial results. Thus, the global cancer cachexia market is projected to be driven by advancements in modern treatment systems and increasing occurrence of cachexia. North America, Europe and Japan are expected to be key markets.

Cachexia is a condition in which progressive loss of adipose tissue as well as skeletal muscle takes place; cancer cachexia is characterized by systemic inflammation, negative protein and energy balance, and an involuntary loss of lean body mass. Serious cachexia is caused by cancers such as pancreatic and gastric cancer, with affected individuals losing 10 to 20 percent of body weight. The severity of cachexia is more in men than in women.  Cachexia is associated with poor functional performance, decreased response to chemotherapy, and greater mortality.

Current treatments include the administration of Megestrol acetate (active proges terone derivative), Medroxyprogesterone    (active progesterone derivative) Ghrelin (gastric peptide hormone), Delta-9-tetrahydrocannabinol (cannabinoid), Melanocortin antagonists (adrenocorticotropic hormone antagonist), Thalidomide (immunomodulatory), Etanercept (immunomodulatory), Eicosapentaenoic acid/omega-3-fatty acids    (lipid), Rikkun-shito (herbal Japanese medicine) , Corticosteroids    (immunomodulatory), Formoterol (β2-adrenergic agonist), Erythropoetin (glycoprotein hormone), ACE inhibitors (heart medications), and β-blockers (heart medications). Combination therapy seeks to integrate diet and exercise (where possible) with medication.

Leading companies like Pfizer are conducting programs in several cachexia drug targets, with the aim of developing multi-modal interventions that target loss of appetite, weight loss, muscle wasting, and/or inflammation. Historically, cachexia treatment research could not progress as the aim was only one aspect – to reverse muscle wasting. However, Pfizer directs efforts towards multiple symptoms simultaneously. The company’s flagship cachexia program focuses on growth differentiation factor-15 (GDF-15), a cytokine, or cellular signalling protein, associated with appetite and energy regulation. GDF-15 is believed to interact with receptors in the brain linked with appetite control, leading to loss of appetite and nausea. Pfizer scientists seek to develop an antibody that blocks GDF-15 in cachexia patients to enable patients restore their appetite and gain weight. Pfizer scientists are also striving to create separate cachexia programs (to fight anorexia and weight loss) that could complement the GDF-15 antibody.

In 2021, Roche announced that the U.S. Food and Drug Administration (FDA) granted Breakthrough Device Designation to their Elecsys® GDF-15 assay as a companion diagnostic (CDx) in cancer treatment. The in vitro diagnostic immunoassay was intended to measure Growth Differentiation Factor-15 (GDF-15) in cachectic patients 18 years of age and older with solid tumours for treatment with Pfizer Inc.'s investigational drug PF-06946860.

Novel treatment methodologies such as the ghrelin receptor agonist anamorelin has delivered initial results and shown promise. Anamorelin is a selective, novel, orally active ghrelin receptor agonist. Ghrelin is an endogenous peptide produced primarily by the stomach. By binding to its receptor, ghrelin stimulates various pathways in the positive regulation of body weight, muscle mass, appetite and metabolism. In 2021, Helsinn Group and Ono Pharmaceutical Co., Ltd. announced that ONO secured approval to manufacture and market Adlumiz® (anamorelin hydrochloride) for the treatment of cancer cachexia in malignant tumors of non-small cell lung cancer, gastric cancer, pancreatic cancer or colorectal cancer in Japan. ONO possesses exclusive rights to develop and commercialize anamorelin in Japan, South Korea and Taiwan. Helsinn holds all rights in the rest of the world.

Key Findings of the Report:

  • Rising cases of cancer cachexia across the world are likely to drive the market.
  • In recent years, understanding of cachexia has increased and leading firms are constantly engaged in finding solutions to the condition. Modern treatment approaches have shown promise in trials. Such advancements in treatment systems and approaches are expected to stimulate the market.
  • North America, Europe and Japan are projected to be major markets.

Market Analysis by Therapeutics, Mechanism of Action, Distribution Channel, and Region:

  • By therapeutics, the market is divided into Progestogens, Corticosteroids, Combination Therapy, and Others.
  • By mechanism of action, the market is classified into Appetite Stimulators and Weight Loss Stabilizers.
  • By distribution channel, the market is segmented into Hospital Pharmacy, Retail Pharmacy, and Online Pharmacy.
  • By region, the market is classified into North America, Europe, Asia Pacific, Latin America, and Middle East and Africa.

About Us

Expert Market Research (EMR) is a leading market research and business intelligence company, ensuring its clients remain at the vanguard of their industries by providing them with exhaustive and actionable market data through its syndicated and custom market reports, covering over 15 major industry domains. The company's expansive and ever-growing database of reports, which are constantly updated, includes reports from industry verticals like chemicals and materials, food and beverages, energy and mining, technology and media, consumer goods, pharmaceuticals, agriculture, and packaging.

EMR leverages its state-of-the-art technological and analytical tools, along with the expertise of its highly skilled team of over 100 analysts and more than 3000 consultants, to help its clients, ranging from Fortune 1000 companies to small and medium-sized enterprises, easily grasp the expansive industry data and help them in formulating market and business strategies, which ensure that they remain ahead of the curve.

Contact Us:

Expert Market Research
Website: www.expertmarketresearch.com
Email: sales@expertmarketresearch.com
US & Canada Phone no: +1-415-325-5166
UK Phone no: +44-702-402-5790

*We at Expert Market Research always thrive to give you the latest information. The numbers in the article are only indicative and may be different from the actual report.

Why Expert Market Research?

Right People

We are technically excellent, strategic, practical, experienced and efficient; our analysts are hand-picked based on having the right attributes to work successfully and execute projects based on your expectations.

Right Methodology

We leverage our cutting-edge technology, our access to trusted databases, and our knowledge of the current models used in the market to deliver you research solutions that are tailored to your needs and put you ahead of the curve.

Right Price

We deliver in-depth and superior quality research in prices that are reasonable, unmatchable, and shows our understanding of your resource structure. We, additionally, offer attractive discounts on our upcoming reports.

Right Support

Our team of expert analysts are at your beck and call to deliver you optimum results that are customised to meet your precise needs within the specified timeframe and help you form a better understanding of the industry.

Similar Reports





NEWSLETTER