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The global gene synthesis market was valued at USD 2.93 Billion in 2025. It is poised to grow at a CAGR of 21.20% during the forecast period of 2026-2035, reaching USD 20.04 Billion by 2035. The market is driven by rising investment in synthetic biology and gene therapy pipelines, growing demand for custom gene synthesis services, and expanding adoption of codon optimization across biopharmaceutical research, including applications in genomics-driven therapy and biomarker-based treatment development.
According to the National Human Genome Research Institute (NHGRI), genomics research is projected to generate between 2 and 40 exabytes of data over the next decade, underscoring sustained demand for synthetic DNA development.
In June 2024, GenScript Biotech Corporation launched its FLASH gene synthesis service, significantly reducing turnaround times for creating plasmids and custom gene constructs used in research and therapy development.
The key players in the market are significantly contributing to market growth by investing in advanced technologies, expanding production capabilities, enhancing service portfolios, and forming strategic collaborations to accelerate innovation, improve efficiency, and meet the evolving demands of end users.
Compound Annual Growth Rate
21.2%
Value in USD Billion
2026-2035
Gene synthesis refers to the artificial construction of synthetic DNA sequences using solid-phase synthesis, oligonucleotide synthesis, and PCR-based enzyme synthesis technologies. These custom gene synthesis services are foundational to synthetic biology, gene therapy, vaccine development, and codon optimization workflows. As per Expert Market Research (EMR), the gene synthesis market is expected to grow at a CAGR of 21.20%, reaching USD 20.04 Billion by 2035. Rising investment in gene cloning, CRISPR-based genome editing, and biopharmaceutical R&D are driving demand for high-precision DNA synthesis services globally.
Advancements in Secure Gene Synthesis Technologies to Boost the Market Value
Increasing emphasis on genetic data security and intellectual property protection is emerging as a key growth driver in the gene synthesis market. As biotechnology workflows become more complex, safeguarding sensitive DNA sequences is critical for maintaining competitive advantage. In April 2026, Beijing Tsingke Biotech Co., Ltd. introduced a “Zero-Contact Sequences” system, enabling fully automated, on-site gene synthesis with minimal human intervention and enhanced data protection. Such innovations are expected to strengthen trust and accelerate adoption, thereby supporting sustained market growth.
Improvement in Ultra-Long DNA Synthesis is Likely to Accelerate the Market Growth
The growing ability to synthesize ultra-long, sequence-perfect DNA is emerging as a transformative trend in the gene synthesis market, enabling complex construct development with higher precision and reduced turnaround times. These advancements are increasingly supporting molecular profiling, genomics-driven therapy, and drug response prediction in advanced research applications. In October 2025, Ansa Biotechnologies introduced a 50 kb clonal DNA product with rapid delivery and full sequence verification, demonstrating significant technological progress. This advancement is expected to strengthen precision research capabilities and accelerate innovation in genomics and therapeutic development globally.
Market Breakup by Components
Market Breakup by Gene Therapy
Market Breakup by Application
Market Breakup by Gene Synthesis Type
Market Breakup by Region
Solid-Phase Synthesis to Lead the Market Share by Gene Synthesis Type
The market is segmented based on gene synthesis type into gene library synthesis, solid phase synthesis, chip-based DNA synthesis, and PCR-based enzyme synthesis. Among these, solid-phase synthesis is expected to lead the market due to its high accuracy, scalability, and efficiency in producing custom DNA sequences. Its dominance is driven by increasing applications in genomics-driven therapy, biomarker-based treatment, and molecular profiling, along with rising use in patient stratification, AI diagnostics, and drug response prediction. These factors are expected to sustain its leadership position over the forecast period.
The regions included in the market are North America, Europe, Asia Pacific, Latin America, and Middle East and Africa. Among these, North America is expected to lead the market, driven by a robust biotechnology ecosystem and the presence of major players. Asia Pacific is expected to register the fastest CAGR, supported by rising government investment in biopharmaceutical manufacturing and expanding synthetic biology research in China and India.
The key features of the market report include patent analysis, funding and investment analysis, and strategic initiatives by the leading players. The major companies in the gene synthesis market are as follows:
ATDBio Ltd is a specialized provider of synthetic DNA products, supporting advances in gene synthesis through high-quality oligonucleotides and custom DNA constructs. Its offerings enable processes such as polymerase cycling assembly and gene cloning. The company plays a significant role in facilitating efficient gene design and production, contributing to innovation and scalability in the market.
Twist Bioscience Corporation is a United States-based synthetic biology company pioneering silicon-based DNA writing technology for cost-effective production of synthetic genes and antibody libraries. Its express gene service delivers genes up to 5 kb within 5-7 business days. Twist's innovations support pharmaceutical R&D, agribusiness, DNA synthesis, and molecular diagnostics applications globally.
Integrated DNA Technologies, Inc. is a United States-based provider of custom oligonucleotide synthesis and gene synthesis services for genomics, molecular diagnostics, and CRISPR applications. IDT supports codon optimization and high-fidelity DNA amplification. In March 2025, IDT partnered with Elegen to offer next-generation DNA synthesis manufacturing for complex gene assembly at commercial scale.
Eurofins Scientific is a European company providing high-quality oligonucleotide synthesis, gene synthesis, and sequencing services. Headquartered in Luxembourg, Eurofins serves academic and pharmaceutical clients globally. The company strengthened its custom gene synthesis portfolio through the acquisition of Blue Heron Biotech, enhancing throughput and capabilities for complex synthetic DNA construct delivery.
Other key players include General Biosystems, Macrogen Co., Ltd., Boster Biological Technology, Creative Biogene, Exonbio, Bioneer Corporation, Trenzyme GmbH, BioCat GmbH, OriGene Technologies, Inc., NZYTech, and Genes and Enzymes.
*Please note that this is only a partial list; the complete list of key players is available in the full report. Additionally, the list of key players can be customized to better suit your needs.*
*While we strive to always give you current and accurate information, the numbers depicted on the website are indicative and may differ from the actual numbers in the main report. At Expert Market Research, we aim to bring you the latest insights and trends in the market. Using our analyses and forecasts, stakeholders can understand the market dynamics, navigate challenges, and capitalize on opportunities to make data-driven strategic decisions.*
Explore our key highlights of the report and gain a concise overview of key findings, trends, and actionable insights that will empower your strategic decisions.
| REPORT FEATURES | DETAILS |
| Base Year | 2025 |
| Historical Period | 2019-2025 |
| Forecast Period | 2026-2035 |
| Scope of the Report |
Historical and Forecast Trends, Industry Drivers and Constraints, Historical and Forecast Market Analysis by Segment:
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| Breakup by Components |
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| Breakup by Gene Therapy |
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| Breakup by Application |
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| Breakup by Gene Synthesis Type |
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| Breakup by Region |
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| Market Dynamics |
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| Competitive Landscape |
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| Companies Covered |
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